Peptide deformylase 1

Details

Name
Peptide deformylase 1
Synonyms
  • 3.5.1.88
  • PDF 1
  • Polypeptide deformylase 1
Gene Name
def1
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Amino acid sequence
>lcl|BSEQ0017254|Peptide deformylase 1
MAVLEIIKHPNEVLETPCERVINFDKKLVKLLKDMHETMLIADGVGLAAPQVGVSLQVAV
VDVDDDTGKIELINPSILEKRGEQVGPEGCLSFPGLYGEVERADYIKVRAQNRRGKVFLL
EAEGFLARAIQHEIDHLHGVLFTSKVTRYYEENELE
Number of residues
156
Molecular Weight
17479.995
Theoretical pI
4.79
GO Classification
Functions
iron ion binding / peptide deformylase activity
Processes
translation
General Function
Peptide deformylase activity
Specific Function
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0017255|Peptide deformylase 1 (def1)
ATGGCAGTTTTAGAAATAATAAAGCATCCAAATGAAGTGTTAGAAACACCATGCGAAAGA
GTAATTAACTTTGATAAAAAGTTAGTGAAATTGTTGAAAGATATGCATGAAACAATGTTA
ATTGCGGACGGAGTCGGTTTAGCTGCGCCTCAAGTAGGTGTAAGCTTGCAAGTAGCGGTT
GTTGATGTCGATGATGATACTGGGAAAATCGAGTTAATCAATCCATCAATATTAGAAAAA
CGTGGTGAACAAGTAGGTCCCGAAGGCTGTTTAAGCTTCCCGGGACTTTATGGTGAAGTA
GAACGTGCCGATTATATTAAAGTAAGAGCGCAAAATCGCCGTGGGAAAGTATTCTTATTA
GAAGCGGAAGGATTTTTAGCGCGTGCAATTCAACATGAAATTGATCATTTACACGGTGTT
TTATTTACATCGAAAGTGACAAGATATTATGAAGAAAACGAACTAGAATAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ819U0
UniProtKB Entry NameDEF1_BACCR
GenBank Protein ID29893819
GenBank Gene IDAE016877
General References
  1. Ivanova N, Sorokin A, Anderson I, Galleron N, Candelon B, Kapatral V, Bhattacharyya A, Reznik G, Mikhailova N, Lapidus A, Chu L, Mazur M, Goltsman E, Larsen N, D'Souza M, Walunas T, Grechkin Y, Pusch G, Haselkorn R, Fonstein M, Ehrlich SD, Overbeek R, Kyrpides N: Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis. Nature. 2003 May 1;423(6935):87-91. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB043102-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-AmideexperimentalunknownDetails