Valacyclovir hydrolase
Details
- Name
- Valacyclovir hydrolase
- Synonyms
- 3.1.-.-
- Biphenyl hydrolase-like protein
- Biphenyl hydrolase-related protein
- Bph-rp
- Breast epithelial mucin-associated antigen
- MCNAA
- VACVase
- Gene Name
- BPHL
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008296|Valacyclovir hydrolase MVAVLGGRGVLRLRLLLSALKPGIHVPRAGPAAAFGTSVTSAKVAVNGVQLHYQQTGEGD HAVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPADFFERDAKD AVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIR DVSKWSERTRKPLEALYGYDYFARTCEKWVDGIRQFKHLPDGNICRHLLPRVQCPALIVH GEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFADEFNKLAEDFLQ
- Number of residues
- 291
- Molecular Weight
- 32542.32
- Theoretical pI
- 9.59
- GO Classification
- Functionshydrolase activityProcessescellular amino acid metabolic process / response to toxic substanceComponentsextracellular exosome / mitochondrion
- General Function
- Hydrolase activity
- Specific Function
- Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.
- Pfam Domain Function
- Abhydrolase_1 (PF00561)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0017423|Valacyclovir hydrolase (BPHL) ATGCCCAGGAATCTGCTTTATTCTCTTTTGTCCTCCCACCTGTCCCCCCATTTCAGCACC TCGGTAACCTCTGCCAAAGTGGCTGTGAATGGCGTTCAGCTGCATTACCAGCAGACTGGA GAGGGAGATCACGCAGTCCTGCTACTTCCTGGGATGTTAGGAAGTGGAGAGACTGATTTT GGACCTCAGCTCAAGAACCTCAATAAGAAGCTCTTCACGGTGGTCGCCTGGGATCCTCGA GGCTATGGACATTCCAGGCCCCCAGATCGCGATTTCCCAGCAGACTTTTTTGAAAGGGAT GCAAAAGATGCTGTTGATTTGATGAAGGCGCTGAAGTTTAAGAAGGTTTCTCTGCTGGGG TGGAGTGATGGGGGCATAACCGCACTCATTGCTGCTGCAAAATATCCATCTTACATCCAC AAGATGGTGATCTGGGGCGCCAACGCCTACGTCACTGACGAAGACAGCATGATATATGAG GGCATCCGAGATGTTTCCAAATGGAGTGAGAGAACAAGAAAGCCTCTAGAAGCCCTCTAT GGGTATGACTACTTTGCCAGAACCTGTGAAAAGTGGGTGGATGGCATAAGACAGTTTAAA CATCTCCCAGATGGTAACATCTGCCGGCACCTGCTGCCCCGGGTCCAGTGCCCCGCCTTG ATTGTGCACGGTGAGAAGGATCCTCTGGTCCCACGGTTTCATGCCGACTTCATTCATAAG CACGTGAAAGGCTCACGGCTGCATTTGATGCCAGAAGGCAAACACAACCTGCATTTGCGT TTTGCAGATGAATTCAACAAGTTAGCAGAAGACTTCCTACAATGA
- Chromosome Location
- 6
- Locus
- 6p25
- External Identifiers
Resource Link UniProtKB ID Q86WA6 UniProtKB Entry Name BPHL_HUMAN GenBank Protein ID 984663 GenBank Gene ID X81372 HGNC ID HGNC:1094 - General References
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