Myosin light chain kinase family member 4

Details

Name
Myosin light chain kinase family member 4
Synonyms
  • 2.7.11.1
  • SGK085
  • Sugen kinase 85
Gene Name
MYLK4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051866|Myosin light chain kinase family member 4
MLKVKRLEEFNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSN
ADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQV
HKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVM
EYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA
KQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGL
SPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPW
LSDHKLHSRLNAQKKKNRGSDAQDFVTK
Number of residues
388
Molecular Weight
44507.535
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / myosin light chain kinase activity
Processes
intracellular signal transduction / peptidyl-serine phosphorylation / peptidyl-threonine phosphorylation
Components
extracellular exosome / intracellular
General Function
Not Available
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051867|Myosin light chain kinase family member 4 (MYLK4)
ATGTTAAAAGTGAAGAGGCTGGAAGAATTCAACACGTGTTATAACAGCAACCAGCTGGAG
AAAATGGCCTTTTTTCAGTGCAGGGAAGAGGTGGAGAAAGTGAAGTGTTTTCTGGAAAAA
AATTCTGGGGACCAGGATTCAAGATCTGGACATAATGAGGCGAAGGAGGTGTGGTCAAAC
GCCGACCTGACGGAAAGGATGCCCGTCAAAAGCAAAAGGACATCAGCCCTCGCAGTTGAC
ATCCCGGCTCCTCCGGCCCCATTTGATCATCGTATTGTGACAGCCAAGCAAGGAGCGGTC
AACAGCTTCTATACTGTGAGCAAGACAGAAATCCTAGGAGGAGGGCGTTTCGGCCAGGTT
CACAAGTGTGAGGAGACGGCCACAGGTCTGAAGCTGGCAGCCAAAATCATCAAGACCAGA
GGCATGAAGGACAAGGAGGAGGTGAAGAACGAGATCAGCGTCATGAACCAGCTGGACCAC
GCGAACCTCATCCAGCTGTACGATGCCTTCGAGTCTAAGAACGACATTGTCCTGGTCATG
GAGTATGTGGATGGTGGGGAGCTGTTTGACCGCATCATCGATGAGAGCTACAATTTGACG
GAGCTTGATACCATCCTGTTCATGAAGCAGATATGTGAGGGGATAAGGCACATGCATCAG
ATGTACATTCTCCACTTGGACCTGAAGCCTGAGAATATCCTGTGTGTGAATCGGGATGCT
AAGCAAATAAAAATTATTGATTTTGGATTGGCCAGAAGATACAAACCCAGAGAGAAGCTG
AAGGTGAACTTTGGAACCCCAGAATTTCTCGCCCCTGAAGTTGTGAACTATGATTTTGTT
TCATTTCCCACTGACATGTGGAGTGTGGGGGTCATCGCCTATATGCTACTTAGCGGTTTG
TCGCCTTTCCTGGGTGACAATGATGCTGAGACGCTGAACAACATCCTGGCCTGCAGGTGG
GACTTAGAGGATGAAGAATTTCAGGACATCTCGGAGGAGGCCAAGGAGTTCATCTCTAAG
CTTCTGATTAAGGAGAAGAGTTGGCGAATAAGTGCAAGCGAAGCTCTCAAGCACCCCTGG
TTGTCAGACCACAAGCTCCACTCCAGACTCAATGCCCAGAAGAAGAAGAATCGTGGCTCT
GATGCCCAGGACTTTGTGACCAAATAG
Chromosome Location
6
Locus
6p25.2
External Identifiers
ResourceLink
UniProtKB IDQ86YV6
UniProtKB Entry NameMYLK4_HUMAN
HGNC IDHGNC:27972
General References
  1. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S: The protein kinase complement of the human genome. Science. 2002 Dec 6;298(5600):1912-34. [Article]
  4. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails