O-GlcNAcase BT_4395

Details

Name
O-GlcNAcase BT_4395
Synonyms
  • 3.2.1.169
  • Beta-hexosaminidase
  • Beta-N-acetylglucosaminidase
  • Beta-N-acetylhexosaminidase
  • Hexosaminidase B
  • N-acetyl-beta-glucosaminidase
Gene Name
Not Available
Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Amino acid sequence
>lcl|BSEQ0012967|O-GlcNAcase BT_4395
MKNNKIYLLGACLLCAVTTFAQNVSLQPPPQQLIVQNKTIDLPAVYQLNGGEEANPHAVK
VLKELLSGKQSSKKGMLISIGEKGDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERG
TYYALQTFAQLLKDGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLKFYGKNKMN
TYIYGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVDFVWAIHPGQDIKWNKEDR
DLLLAKFEKMYQLGVRSFAVFFDDISGEGTNPQKQAELLNYIDEKFAQVKPDINQLVMCP
TEYNKSWSNPNGNYLTTLGDKLNPSIQIMWTGDRVISDITRDGISWINERIKRPAYIWWN
FPVSDYVRDHLLLGPVYGNDTTIAKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDT
WQTWKDAIRTILPSAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFLKAFKEGKN
YDKADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQFKLTAEMGEEVLKMVEGR
NESYFLRKYNHVKALQQQMFYIDQTSNQNPYQPGVKTATRVIKPLIDRTFATVVKFFNQK
FNAHLDATTDYMPHKMISNVEQIKNLPLQVKANRVLISPANEVVKWAAGNSVEIELDAIY
PGENIQINFGKDAPCTWGRLEISTDGKEWKTVDLKQKESRLSAGLQKAPVKFVRFTNVSD
EEQQVYLRQFVLTIEKK
Number of residues
737
Molecular Weight
84484.62
Theoretical pI
7.0
GO Classification
Functions
beta-N-acetylglucosaminidase activity
Processes
carbohydrate metabolic process / protein deglycosylation
General Function
Beta-n-acetylglucosaminidase activity
Specific Function
Can hydrolyze the glycosidic link of O-GlcNAcylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates (in vitro).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0012968|O-GlcNAcase BT_4395
ATGAAAAACAACAAGATTTATCTGTTGGGAGCCTGCCTCCTGTGTGCTGTTACTACCTTT
GCGCAGAATGTTAGTCTGCAACCTCCTCCTCAACAACTCATTGTTCAAAACAAGACCATC
GATCTGCCTGCTGTCTATCAGCTGAATGGCGGGGAAGAAGCCAATCCGCATGCTGTAAAG
GTACTGAAAGAACTGCTTTCCGGTAAGCAAAGCAGCAAGAAAGGGATGCTTATTTCTATT
GGTGAGAAAGGTGACAAGAGTGTGCGTAAATATAGCCGCCAGATTCCTGACCACAAAGAA
GGCTATTACCTGTCTGTGAATGAGAAGGAAATCGTACTGGCCGGAAACGACGAACGAGGT
ACTTATTACGCTCTGCAAACTTTTGCGCAATTGCTGAAAGACGGAAAGCTGCCCGAAGTA
GAAATCAAAGATTACCCTTCTGTACGGTATCGGGGAGTGGTAGAAGGGTTTTACGGAACT
CCCTGGAGCCATCAGGCACGCCTCAGCCAACTGAAGTTTTACGGTAAAAACAAGATGAAC
ACTTATATATACGGTCCGAAAGATGATCCGTATCATAGTGCTCCCAACTGGCGTTTGCCT
TATCCCGACAAAGAAGCTGCCCAGTTGCAGGAATTGGTGGCGGTAGCCAACGAAAATGAA
GTTGACTTTGTATGGGCGATCCATCCGGGACAGGATATCAAATGGAATAAGGAAGATCGT
GATCTTCTGCTCGCTAAATTTGAGAAGATGTATCAGCTCGGTGTCCGTTCGTTCGCCGTA
TTCTTTGATGATATCTCCGGTGAAGGTACTAATCCGCAGAAACAAGCGGAACTACTGAAC
TACATTGATGAGAAATTCGCACAGGTAAAACCGGATATAAACCAACTGGTGATGTGCCCT
ACGGAATATAATAAAAGCTGGTCGAACCCTAATGGCAATTATCTGACTACGCTGGGCGAT
AAACTCAATCCTTCCATTCAGATCATGTGGACGGGAGACCGTGTCATTTCCGATATTACC
CGTGACGGCATTTCATGGATTAACGAACGAATCAAGCGTCCGGCTTATATCTGGTGGAAC
TTCCCGGTGTCCGATTATGTGCGCGATCATCTGCTTCTCGGTCCTGTGTATGGCAACGAT
ACTACGATTGCCAAAGAGATGTCGGGCTTTGTAACCAATCCGATGGAACATGCCGAATCG
TCAAAGATAGCGATTTATAGTGTGGCAAGTTATGCCTGGAATCCTGCCAAGTATGATACA
TGGCAGACGTGGAAGGATGCGATCCGTACCATTCTGCCAAGTGCAGCGGAAGAACTTGAA
TGCTTTGCAATGCACAATTCCGACTTGGGACCTAACGGACATGGATACCGCCGCGAAGAA
TCTATGGATATCCAACCGGCTGCCGAACGTTTCCTGAAAGCGTTCAAAGAAGGCAAAAAT
TACGATAAGGCAGATTTCGAGACTCTTCAATATACGTTCGAACGTATGAAAGAATCCGCC
GATATCCTGTTGATGAATACGGAGAACAAACCGTTGATTGTGGAAATCACTCCTTGGGTG
CATCAGTTTAAACTGACGGCTGAAATGGGAGAAGAAGTGCTGAAGATGGTAGAAGGCCGG
AATGAATCTTATTTTCTGCGGAAATACAATCATGTGAAGGCTTTGCAGCAACAGATGTTC
TATATCGATCAGACGAGTAATCAGAATCCTTATCAACCGGGAGTAAAGACAGCTACGCGA
GTGATAAAACCATTAATTGACCGGACTTTTGCCACAGTTGTGAAATTCTTCAATCAAAAG
TTTAATGCTCATCTGGATGCCACTACCGATTATATGCCGCATAAGATGATCAGTAATGTG
GAGCAGATCAAGAACCTGCCGTTGCAGGTGAAAGCGAACCGTGTACTCATTTCTCCTGCC
AATGAAGTTGTGAAATGGGCGGCTGGAAACAGTGTTGAAATAGAACTGGATGCTATCTAT
CCGGGAGAGAATATTCAGATAAACTTTGGTAAGGATGCTCCTTGTACATGGGGACGCCTT
GAAATCTCTACGGACGGCAAGGAATGGAAAACGGTGGATCTGAAGCAGAAAGAAAGCAGA
TTGTCGGCCGGTTTGCAGAAAGCTCCTGTGAAGTTTGTCCGCTTCACGAATGTGAGTGAT
GAAGAACAGCAGGTCTATTTGCGCCAGTTTGTTCTGACTATAGAGAAGAAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ89ZI2
UniProtKB Entry NameOGA_BACTN
GenBank Protein ID29337303
GenBank Gene IDAE015928
General References
  1. Xu J, Bjursell MK, Himrod J, Deng S, Carmichael LK, Chiang HC, Hooper LV, Gordon JI: A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science. 2003 Mar 28;299(5615):2074-6. [Article]
  2. Dennis RJ, Taylor EJ, Macauley MS, Stubbs KA, Turkenburg JP, Hart SJ, Black GN, Vocadlo DJ, Davies GJ: Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity. Nat Struct Mol Biol. 2006 Apr;13(4):365-71. Epub 2006 Mar 26. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB08255(3AR,5R,6S,7R,7AR)-5-(HYDROXYMETHYL)-2-PROPYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOLexperimentalunknownDetails
DB07432[[(3R,4R,5S,6R)-3-(butanoylamino)-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-ylidene]amino] N-phenylcarbamateexperimentalunknownDetails
DB00428Streptozocinapproved, investigationalyesantagonistDetails