O-GlcNAcase BT_4395
Details
- Name
- O-GlcNAcase BT_4395
- Synonyms
- 3.2.1.169
- Beta-hexosaminidase
- Beta-N-acetylglucosaminidase
- Beta-N-acetylhexosaminidase
- Hexosaminidase B
- N-acetyl-beta-glucosaminidase
- Gene Name
- Not Available
- Organism
- Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
- Amino acid sequence
>lcl|BSEQ0012967|O-GlcNAcase BT_4395 MKNNKIYLLGACLLCAVTTFAQNVSLQPPPQQLIVQNKTIDLPAVYQLNGGEEANPHAVK VLKELLSGKQSSKKGMLISIGEKGDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERG TYYALQTFAQLLKDGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLKFYGKNKMN TYIYGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVDFVWAIHPGQDIKWNKEDR DLLLAKFEKMYQLGVRSFAVFFDDISGEGTNPQKQAELLNYIDEKFAQVKPDINQLVMCP TEYNKSWSNPNGNYLTTLGDKLNPSIQIMWTGDRVISDITRDGISWINERIKRPAYIWWN FPVSDYVRDHLLLGPVYGNDTTIAKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDT WQTWKDAIRTILPSAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFLKAFKEGKN YDKADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQFKLTAEMGEEVLKMVEGR NESYFLRKYNHVKALQQQMFYIDQTSNQNPYQPGVKTATRVIKPLIDRTFATVVKFFNQK FNAHLDATTDYMPHKMISNVEQIKNLPLQVKANRVLISPANEVVKWAAGNSVEIELDAIY PGENIQINFGKDAPCTWGRLEISTDGKEWKTVDLKQKESRLSAGLQKAPVKFVRFTNVSD EEQQVYLRQFVLTIEKK
- Number of residues
- 737
- Molecular Weight
- 84484.62
- Theoretical pI
- 7.0
- GO Classification
- Functionsbeta-N-acetylglucosaminidase activityProcessescarbohydrate metabolic process / protein deglycosylation
- General Function
- Beta-n-acetylglucosaminidase activity
- Specific Function
- Can hydrolyze the glycosidic link of O-GlcNAcylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates (in vitro).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012968|O-GlcNAcase BT_4395 ATGAAAAACAACAAGATTTATCTGTTGGGAGCCTGCCTCCTGTGTGCTGTTACTACCTTT GCGCAGAATGTTAGTCTGCAACCTCCTCCTCAACAACTCATTGTTCAAAACAAGACCATC GATCTGCCTGCTGTCTATCAGCTGAATGGCGGGGAAGAAGCCAATCCGCATGCTGTAAAG GTACTGAAAGAACTGCTTTCCGGTAAGCAAAGCAGCAAGAAAGGGATGCTTATTTCTATT GGTGAGAAAGGTGACAAGAGTGTGCGTAAATATAGCCGCCAGATTCCTGACCACAAAGAA GGCTATTACCTGTCTGTGAATGAGAAGGAAATCGTACTGGCCGGAAACGACGAACGAGGT ACTTATTACGCTCTGCAAACTTTTGCGCAATTGCTGAAAGACGGAAAGCTGCCCGAAGTA GAAATCAAAGATTACCCTTCTGTACGGTATCGGGGAGTGGTAGAAGGGTTTTACGGAACT CCCTGGAGCCATCAGGCACGCCTCAGCCAACTGAAGTTTTACGGTAAAAACAAGATGAAC ACTTATATATACGGTCCGAAAGATGATCCGTATCATAGTGCTCCCAACTGGCGTTTGCCT TATCCCGACAAAGAAGCTGCCCAGTTGCAGGAATTGGTGGCGGTAGCCAACGAAAATGAA GTTGACTTTGTATGGGCGATCCATCCGGGACAGGATATCAAATGGAATAAGGAAGATCGT GATCTTCTGCTCGCTAAATTTGAGAAGATGTATCAGCTCGGTGTCCGTTCGTTCGCCGTA TTCTTTGATGATATCTCCGGTGAAGGTACTAATCCGCAGAAACAAGCGGAACTACTGAAC TACATTGATGAGAAATTCGCACAGGTAAAACCGGATATAAACCAACTGGTGATGTGCCCT ACGGAATATAATAAAAGCTGGTCGAACCCTAATGGCAATTATCTGACTACGCTGGGCGAT AAACTCAATCCTTCCATTCAGATCATGTGGACGGGAGACCGTGTCATTTCCGATATTACC CGTGACGGCATTTCATGGATTAACGAACGAATCAAGCGTCCGGCTTATATCTGGTGGAAC TTCCCGGTGTCCGATTATGTGCGCGATCATCTGCTTCTCGGTCCTGTGTATGGCAACGAT ACTACGATTGCCAAAGAGATGTCGGGCTTTGTAACCAATCCGATGGAACATGCCGAATCG TCAAAGATAGCGATTTATAGTGTGGCAAGTTATGCCTGGAATCCTGCCAAGTATGATACA TGGCAGACGTGGAAGGATGCGATCCGTACCATTCTGCCAAGTGCAGCGGAAGAACTTGAA TGCTTTGCAATGCACAATTCCGACTTGGGACCTAACGGACATGGATACCGCCGCGAAGAA TCTATGGATATCCAACCGGCTGCCGAACGTTTCCTGAAAGCGTTCAAAGAAGGCAAAAAT TACGATAAGGCAGATTTCGAGACTCTTCAATATACGTTCGAACGTATGAAAGAATCCGCC GATATCCTGTTGATGAATACGGAGAACAAACCGTTGATTGTGGAAATCACTCCTTGGGTG CATCAGTTTAAACTGACGGCTGAAATGGGAGAAGAAGTGCTGAAGATGGTAGAAGGCCGG AATGAATCTTATTTTCTGCGGAAATACAATCATGTGAAGGCTTTGCAGCAACAGATGTTC TATATCGATCAGACGAGTAATCAGAATCCTTATCAACCGGGAGTAAAGACAGCTACGCGA GTGATAAAACCATTAATTGACCGGACTTTTGCCACAGTTGTGAAATTCTTCAATCAAAAG TTTAATGCTCATCTGGATGCCACTACCGATTATATGCCGCATAAGATGATCAGTAATGTG GAGCAGATCAAGAACCTGCCGTTGCAGGTGAAAGCGAACCGTGTACTCATTTCTCCTGCC AATGAAGTTGTGAAATGGGCGGCTGGAAACAGTGTTGAAATAGAACTGGATGCTATCTAT CCGGGAGAGAATATTCAGATAAACTTTGGTAAGGATGCTCCTTGTACATGGGGACGCCTT GAAATCTCTACGGACGGCAAGGAATGGAAAACGGTGGATCTGAAGCAGAAAGAAAGCAGA TTGTCGGCCGGTTTGCAGAAAGCTCCTGTGAAGTTTGTCCGCTTCACGAATGTGAGTGAT GAAGAACAGCAGGTCTATTTGCGCCAGTTTGTTCTGACTATAGAGAAGAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q89ZI2 UniProtKB Entry Name OGA_BACTN GenBank Protein ID 29337303 GenBank Gene ID AE015928 - General References
- Xu J, Bjursell MK, Himrod J, Deng S, Carmichael LK, Chiang HC, Hooper LV, Gordon JI: A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science. 2003 Mar 28;299(5615):2074-6. [Article]
- Dennis RJ, Taylor EJ, Macauley MS, Stubbs KA, Turkenburg JP, Hart SJ, Black GN, Vocadlo DJ, Davies GJ: Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity. Nat Struct Mol Biol. 2006 Apr;13(4):365-71. Epub 2006 Mar 26. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB08255 (3AR,5R,6S,7R,7AR)-5-(HYDROXYMETHYL)-2-PROPYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL experimental unknown Details DB07432 [[(3R,4R,5S,6R)-3-(butanoylamino)-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-ylidene]amino] N-phenylcarbamate experimental unknown Details DB00428 Streptozocin approved, investigational yes antagonist Details