2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Details
- Name
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- Synonyms
- 4.6.1.12
- MECDP-synthase
- Gene Name
- ispF
- Organism
- Shewanella oneidensis (strain MR-1)
- Amino acid sequence
>lcl|BSEQ0012848|2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase MKIRIGHGFDVHKFGEPRPLILCGVEVPYETGLVAHSDGDVVLHAISDAILGAMALGDIG KHFPDTDAAYKGADSRVLLRHCYALAKAKGFELGNLDVTIIAQAPKMAPHIEDMRQVLAA DLNADVADINVKATTTEKLGFTGRKEGIAVEAVVLLSRQ
- Number of residues
- 159
- Molecular Weight
- 16995.47
- Theoretical pI
- 6.39
- GO Classification
- Functions2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity / metal ion bindingProcessesisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway / terpenoid biosynthetic process
- General Function
- Metal ion binding
- Specific Function
- Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).
- Pfam Domain Function
- YgbB (PF02542)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012849|2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF) ATGAAAATCCGAATAGGCCATGGTTTTGATGTCCATAAATTTGGTGAACCACGCCCGTTA ATTTTATGTGGCGTCGAAGTACCCTACGAAACTGGCTTGGTGGCCCACTCCGATGGTGAC GTGGTGTTACATGCCATATCCGACGCCATTTTAGGCGCGATGGCGCTGGGTGACATTGGC AAACATTTCCCCGATACCGATGCAGCCTATAAGGGCGCAGATAGTCGAGTCTTGCTTCGC CACTGCTATGCGTTAGCAAAGGCGAAGGGATTTGAGCTGGGCAATCTGGATGTCACTATC ATTGCGCAGGCGCCTAAAATGGCGCCGCATATCGAGGATATGCGCCAAGTGCTAGCAGCC GATCTCAATGCTGATGTTGCTGACATTAATGTGAAGGCCACTACCACTGAGAAACTCGGG TTTACGGGCCGAAAAGAAGGCATTGCAGTCGAAGCTGTCGTATTACTCAGCCGCCAATAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8EBR3 UniProtKB Entry Name ISPF_SHEON GenBank Protein ID 24345351 GenBank Gene ID AE014299 - General References
- Heidelberg JF, Paulsen IT, Nelson KE, Gaidos EJ, Nelson WC, Read TD, Eisen JA, Seshadri R, Ward N, Methe B, Clayton RA, Meyer T, Tsapin A, Scott J, Beanan M, Brinkac L, Daugherty S, DeBoy RT, Dodson RJ, Durkin AS, Haft DH, Kolonay JF, Madupu R, Peterson JD, Umayam LA, White O, Wolf AM, Vamathevan J, Weidman J, Impraim M, Lee K, Berry K, Lee C, Mueller J, Khouri H, Gill J, Utterback TR, McDonald LA, Feldblyum TV, Smith HO, Venter JC, Nealson KH, Fraser CM: Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis. Nat Biotechnol. 2002 Nov;20(11):1118-23. Epub 2002 Oct 7. [Article]
- Ni S, Robinson H, Marsing GC, Bussiere DE, Kennedy MA: Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 A: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity. Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):1949-57. Epub 2004 Oct 20. [Article]