Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Details
- Name
- Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
- Synonyms
- 2-aminoadipate aminotransferase
- 2-aminoadipate transaminase
- AadAT
- Alpha-aminoadipate aminotransferase
- KAT/AadAT
- KAT2
- Kynurenine aminotransferase II
- Kynurenine--oxoglutarate aminotransferase II
- Kynurenine--oxoglutarate transaminase 2
- Kynurenine--oxoglutarate transaminase II
- Gene Name
- AADAT
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001450|Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL IKESL
- Number of residues
- 425
- Molecular Weight
- 47351.17
- Theoretical pI
- 6.96
- GO Classification
- Functions2-aminoadipate transaminase activity / kynurenine-oxoglutarate transaminase activity / protein homodimerization activity / pyridoxal phosphate bindingProcesses2-oxoglutarate metabolic process / biosynthetic process / cellular nitrogen compound metabolic process / glutamate metabolic process / kynurenine metabolic process / L-kynurenine metabolic process / L-lysine catabolic process to acetyl-CoA via saccharopine / lysine catabolic process / small molecule metabolic process / tryptophan catabolic process / tryptophan catabolic process to kynurenineComponentsmitochondrial matrix
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
- Pfam Domain Function
- Aminotran_1_2 (PF00155)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion
- Gene sequence
>lcl|BSEQ0016189|Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (AADAT) ATGAATTACGCACGGTTCATCACGGCAGCGAGCGCAGCCAGAAACCCTTCTCCCATCCGG ACCATGAGTGAGAAACGGGCTGACATATTGAGCAGAGGACCAAAATCGATGATCTCCTTG GCTGGTGGCTTACCAAATCCAAACATGTTTCCTTTTAAGACTGCCGTAATCACTGTAGAA AATGGAAAGACCATCCAATTTGGAGAAGAGATGATGAAGAGAGCACTTCAGTATTCTCCG AGTGCTGGAATTCCAGAGCTTTTGTCCTGGCTAAAACAGTTACAAATAAAATTGCATAAT CCTCCTACCATCCATTACCCACCCAGTCAAGGACAAATGGATCTATGTGTCACATCTGGC AGCCAACAAGGTCTTTGTAAGGTGTTTGAAATGATCATTAATCCTGGAGATAATGTCCTC CTAGATGAACCTGCTTATTCAGGAACTCTTCAAAGTCTGCACCCACTGGGCTGCAACATT ATTAATGTTGCCAGTGATGAAAGTGGGATTGTTCCAGATTCCCTAAGAGACATACTTTCC AGATGGAAACCAGAAGATGCAAAGAATCCCCAGAAAAACACCCCCAAATTTCTTTATACT GTTCCAAATGGCAACAACCCTACTGGAAACTCATTAACCAGTGAACGCAAAAAGGAAATC TATGAGCTTGCAAGAAAATATGATTTCCTCATAATAGAAGATGATCCTTACTATTTTCTC CAGTTTAACAAGTTCAGGGTACCAACATTTCTTTCCATGGATGTTGATGGACGTGTCATC AGAGCTGACTCTTTTTCAAAAATCATTTCCTCTGGGTTGAGAATAGGATTTTTAACTGGT CCAAAACCCTTAATAGAGAGAGTTATTTTACACATACAAGTTTCAACATTGCACCCCAGC ACTTTTAACCAGCTCATGATATCACAGCTTCTACACGAATGGGGAGAAGAAGGTTTCATG GCTCATGTAGACAGGGTTATTGATTTCTATAGTAACCAGAAGGATGCAATACTGGCAGCT GCAGACAAGTGGTTAACTGGTTTGGCAGAATGGCATGTTCCTGCTGCTGGAATGTTTTTA TGGATTAAAGTTAAAGGCATTAATGATGTAAAAGAACTGATTGAAGAAAAGGCCGTTAAG ATGGGGGTATTAATGCTCCCTGGAAATGCTTTCTACGTCGATAGCTCAGCTCCTAGCCCT TACTTGAGAGCATCCTTCTCTTCAGCTTCTCCAGAACAGATGGATGTGGCCTTCCAGGTA TTAGCACAACTTATAAAAGAATCTTTATGA
- Chromosome Location
- 4
- Locus
- 4q33
- External Identifiers
Resource Link UniProtKB ID Q8N5Z0 UniProtKB Entry Name AADAT_HUMAN GenBank Protein ID 6165634 GenBank Gene ID AF097994 GenAtlas ID AADAT HGNC ID HGNC:17929 - General References
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