DAN domain family member 5
Details
- Name
- DAN domain family member 5
- Synonyms
- CER2
- Cerberus-like protein 2
- Cerl-2
- CKTSF1B3
- Cysteine knot superfamily 1, BMP antagonist 3
- GREM3
- Gremlin-3
- SP1
- Gene Name
- DAND5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013719|DAN domain family member 5 MLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQVFSRPGCSAIRL RNHLCFGHCSSLYIPGSDPTPLVLCNSCMPARKRWAPVVLWCLTGSSASRRRVKISTMLI EGCHCSPKA
- Number of residues
- 189
- Molecular Weight
- 20179.56
- Theoretical pI
- Not Available
- GO Classification
- Functionsmorphogen activityProcessesatrial septum development / determination of heart left/right asymmetry / determination of left/right asymmetry in lateral mesoderm / negative regulation of BMP signaling pathway / negative regulation of nodal signaling pathway / negative regulation of transforming growth factor beta receptor signaling pathway / sequestering of nodal from receptor via nodal binding / ventricular septum developmentComponentsextracellular region
- General Function
- Morphogen activity
- Specific Function
- Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).
- Pfam Domain Function
- DAN (PF03045)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0013720|DAN domain family member 5 (DAND5) ATGCTCCTTGGCCAGCTATCCACTCTTCTGTGCCTGCTTAGCGGGGCCCTGCCTACAGGC TCAGGGAGGCCTGAACCCCAGTCTCCTCGACCTCAGTCCTGGGCTGCAGCCAATCAGACC TGGGCTCTGGGCCCAGGGGCCCTGCCCCCACTGGTGCCAGCTTCTGCCCTTGGGAGCTGG AAGGCCTTCTTGGGCCTGCAGAAAGCCAGGCAGCTGGGGATGGGCAGGCTGCAGCGTGGG CAAGACGAGGTGGCTGCTGTGACTCTGCCGCTGAACCCTCAGGAAGTGATCCAGGGGATG TGTAAGGCTGTGCCCTTCGTTCAGGTGTTCTCCCGGCCCGGCTGCTCAGCCATACGCCTC CGAAATCATCTGTGCTTTGGTCATTGCTCCTCTCTCTACATCCCTGGCTCGGACCCCACC CCACTAGTCCTGTGCAACAGCTGTATGCCTGCTCGCAAGCGTTGGGCACCCGTGGTCCTG TGGTGTCTCACTGGCAGCTCAGCCTCCCGTCGACGGGTGAAGATATCCACCATGCTGATC GAGGGGTGTCACTGCAGCCCAAAAGCATGA
- Chromosome Location
- 19
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8N907 UniProtKB Entry Name DAND5_HUMAN HGNC ID HGNC:26780 - General References
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- Katoh M, Katoh M: Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico. Oncol Rep. 2004 Aug;12(2):423-7. [Article]