NADPH oxidase organizer 1
Details
- Name
- NADPH oxidase organizer 1
- Synonyms
- NADPH oxidase regulatory protein
- Nox organizer 1
- Nox-organizing protein 1
- P41NOX
- SH3 and PX domain-containing protein 5
- SH3PXD5
- Gene Name
- NOXO1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004758|NADPH oxidase organizer 1 MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEA GLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTI TGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTR DRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGP QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALL SGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQG RPRGCVDSVPHPTTEQ
- Number of residues
- 376
- Molecular Weight
- 41252.315
- Theoretical pI
- 10.23
- GO Classification
- Functionsenzyme binding / identical protein binding / phosphatidylinositol binding / phospholipid binding / superoxide-generating NADPH oxidase activator activityProcessesextracellular matrix disassembly / regulation of hydrogen peroxide metabolic process / regulation of respiratory burst / small GTPase mediated signal transduction / superoxide metabolic processComponentsintracellular / NADPH oxidase complex / plasma membrane
- General Function
- Superoxide-generating nadph oxidase activator activity
- Specific Function
- Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019282|NADPH oxidase organizer 1 (NOXO1) ATGGCAGGCCCCCGATACCCAGTTTCAGTGCAAGGGGCAGCCCTGGTGCAGATCAAGAGG CTCCAAACGTTTGCCTTCTCTGTGCGCTGGTCAGACGGCAGCGACACCTTCGTGCGCAGG AGTTGGGACGAATTCAGGCAGCTCAAGACCCTCAAGGAGACCTTCCCGGTGGAGGCGGGC CTGCTGCGGAGATCTGACCGCGTTCTCCCAAAGCTTCTCGGTCAGGCCAGCCTGGATGCA CCACTGTTGGGACGCGTGGGGCGCACGAGCCGCGGCCTGGCGCGCCTGCAGCTGTTGGAA ACCTATTCTCGGAGGCTGCTGGCGACTGCAGAGCGCGTGGCACGGAGCCCGACGATCACT GGCTTCTTCGCACCGCAACCCCTGGACCTGGAGCCCGCGCTGCCACCCGGCAGCCGGGTG ATCCTGCCCACCCCAGAGGAGCAGCCTCTTTCTCGCGCTGCGGGCCGCCTCTCCATCCAC AGTCTGGAGGCTCAGAGCCTGCGCTGCCTGCAGCCCTTCTGTACCCAGGACACGCGGGAT AGGCCTTTTCAGGCGCAGGCCCAGGAGAGCCTGGACGTGCTGCTGCGGCACCCCTCAGGC TGGTGGCTGGTGGAGAACGAAGACCGGCAGACCGCCTGGTTTCCAGCGCCCTACCTGGAG GAGGCGGCCCCGGGCCAAGGCCGGGAGGGAGGCCCGTCCCTAGGGAGCAGCGGTCCCCAG TTCTGTGCTTCCCGCGCCTACGAGAGCAGCCGCGCAGATGAGCTGTCCGTGCCCGCGGGG GCGCGCGTGCGCGTGTTGGAAACGTCAGACCGCGGCTGGTGGCTATGCAGGTACGGCGAC CGGGCGGGCCTACTCCCCGCGGTGCTGCTGCGGCCGGAAGGGCTGGGCGCTCTCCTGAGC GGGACGGGGTTCCGTGGAGGAGACGACCCGGCGGGTGAGGCCCGGGGCTTCCCTGAACCC TCCCAGGCCACCGCCCCTCCCCCCACCGTGCCCACCCGACCTTCGCCGGGCGCCATCCAG AGCCGCTGCTGCACCGTCACACGCAGGGCCCTGGAGCGGCGCCCACGGCGCCAGGGCCGC CCTCGAGGGTGCGTGGACTCTGTGCCGCACCCCACGACGGAGCAGTGA
- Chromosome Location
- 16
- Locus
- 16p13.3
- External Identifiers
Resource Link UniProtKB ID Q8NFA2 UniProtKB Entry Name NOXO1_HUMAN GenBank Protein ID 25573148 GenBank Gene ID AF539796 HGNC ID HGNC:19404 - General References
- Banfi B, Clark RA, Steger K, Krause KH: Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem. 2003 Feb 7;278(6):3510-3. Epub 2002 Dec 6. [Article]
- Geiszt M, Lekstrom K, Witta J, Leto TL: Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem. 2003 May 30;278(22):20006-12. Epub 2003 Mar 25. [Article]
- Takeya R, Ueno N, Kami K, Taura M, Kohjima M, Izaki T, Nunoi H, Sumimoto H: Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. J Biol Chem. 2003 Jul 4;278(27):25234-46. Epub 2003 Apr 25. [Article]
- Cheng G, Lambeth JD: NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. J Biol Chem. 2004 Feb 6;279(6):4737-42. Epub 2003 Nov 14. [Article]
- Cheng G, Lambeth JD: Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3. Gene. 2005 Aug 15;356:118-26. [Article]
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- Banfi B, Malgrange B, Knisz J, Steger K, Dubois-Dauphin M, Krause KH: NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem. 2004 Oct 29;279(44):46065-72. Epub 2004 Aug 23. [Article]
- Ueno N, Takeya R, Miyano K, Kikuchi H, Sumimoto H: The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators. J Biol Chem. 2005 Jun 17;280(24):23328-39. Epub 2005 Apr 11. [Article]
- Park HS, Park D, Bae YS: Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. Biochem Biophys Res Commun. 2006 Jan 20;339(3):985-90. [Article]
- Yamamoto A, Kami K, Takeya R, Sumimoto H: Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1). Biochem Biophys Res Commun. 2007 Jan 12;352(2):560-5. Epub 2006 Nov 20. [Article]
- Gianni D, Diaz B, Taulet N, Fowler B, Courtneidge SA, Bokoch GM: Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal. 2009 Sep 15;2(88):ra54. doi: 10.1126/scisignal.2000370. [Article]
- Gianni D, DerMardirossian C, Bokoch GM: Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. Eur J Cell Biol. 2011 Feb-Mar;90(2-3):164-71. doi: 10.1016/j.ejcb.2010.05.007. Epub 2010 Jul 6. [Article]