NADPH oxidase organizer 1

Details

Name
NADPH oxidase organizer 1
Synonyms
  • NADPH oxidase regulatory protein
  • Nox organizer 1
  • Nox-organizing protein 1
  • P41NOX
  • SH3 and PX domain-containing protein 5
  • SH3PXD5
Gene Name
NOXO1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004758|NADPH oxidase organizer 1
MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEA
GLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTI
TGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTR
DRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGP
QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALL
SGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQG
RPRGCVDSVPHPTTEQ
Number of residues
376
Molecular Weight
41252.315
Theoretical pI
10.23
GO Classification
Functions
enzyme binding / identical protein binding / phosphatidylinositol binding / phospholipid binding / superoxide-generating NADPH oxidase activator activity
Processes
extracellular matrix disassembly / regulation of hydrogen peroxide metabolic process / regulation of respiratory burst / small GTPase mediated signal transduction / superoxide metabolic process
Components
intracellular / NADPH oxidase complex / plasma membrane
General Function
Superoxide-generating nadph oxidase activator activity
Specific Function
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0019282|NADPH oxidase organizer 1 (NOXO1)
ATGGCAGGCCCCCGATACCCAGTTTCAGTGCAAGGGGCAGCCCTGGTGCAGATCAAGAGG
CTCCAAACGTTTGCCTTCTCTGTGCGCTGGTCAGACGGCAGCGACACCTTCGTGCGCAGG
AGTTGGGACGAATTCAGGCAGCTCAAGACCCTCAAGGAGACCTTCCCGGTGGAGGCGGGC
CTGCTGCGGAGATCTGACCGCGTTCTCCCAAAGCTTCTCGGTCAGGCCAGCCTGGATGCA
CCACTGTTGGGACGCGTGGGGCGCACGAGCCGCGGCCTGGCGCGCCTGCAGCTGTTGGAA
ACCTATTCTCGGAGGCTGCTGGCGACTGCAGAGCGCGTGGCACGGAGCCCGACGATCACT
GGCTTCTTCGCACCGCAACCCCTGGACCTGGAGCCCGCGCTGCCACCCGGCAGCCGGGTG
ATCCTGCCCACCCCAGAGGAGCAGCCTCTTTCTCGCGCTGCGGGCCGCCTCTCCATCCAC
AGTCTGGAGGCTCAGAGCCTGCGCTGCCTGCAGCCCTTCTGTACCCAGGACACGCGGGAT
AGGCCTTTTCAGGCGCAGGCCCAGGAGAGCCTGGACGTGCTGCTGCGGCACCCCTCAGGC
TGGTGGCTGGTGGAGAACGAAGACCGGCAGACCGCCTGGTTTCCAGCGCCCTACCTGGAG
GAGGCGGCCCCGGGCCAAGGCCGGGAGGGAGGCCCGTCCCTAGGGAGCAGCGGTCCCCAG
TTCTGTGCTTCCCGCGCCTACGAGAGCAGCCGCGCAGATGAGCTGTCCGTGCCCGCGGGG
GCGCGCGTGCGCGTGTTGGAAACGTCAGACCGCGGCTGGTGGCTATGCAGGTACGGCGAC
CGGGCGGGCCTACTCCCCGCGGTGCTGCTGCGGCCGGAAGGGCTGGGCGCTCTCCTGAGC
GGGACGGGGTTCCGTGGAGGAGACGACCCGGCGGGTGAGGCCCGGGGCTTCCCTGAACCC
TCCCAGGCCACCGCCCCTCCCCCCACCGTGCCCACCCGACCTTCGCCGGGCGCCATCCAG
AGCCGCTGCTGCACCGTCACACGCAGGGCCCTGGAGCGGCGCCCACGGCGCCAGGGCCGC
CCTCGAGGGTGCGTGGACTCTGTGCCGCACCCCACGACGGAGCAGTGA
Chromosome Location
16
Locus
16p13.3
External Identifiers
ResourceLink
UniProtKB IDQ8NFA2
UniProtKB Entry NameNOXO1_HUMAN
GenBank Protein ID25573148
GenBank Gene IDAF539796
HGNC IDHGNC:19404
General References
  1. Banfi B, Clark RA, Steger K, Krause KH: Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem. 2003 Feb 7;278(6):3510-3. Epub 2002 Dec 6. [Article]
  2. Geiszt M, Lekstrom K, Witta J, Leto TL: Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem. 2003 May 30;278(22):20006-12. Epub 2003 Mar 25. [Article]
  3. Takeya R, Ueno N, Kami K, Taura M, Kohjima M, Izaki T, Nunoi H, Sumimoto H: Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. J Biol Chem. 2003 Jul 4;278(27):25234-46. Epub 2003 Apr 25. [Article]
  4. Cheng G, Lambeth JD: NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. J Biol Chem. 2004 Feb 6;279(6):4737-42. Epub 2003 Nov 14. [Article]
  5. Cheng G, Lambeth JD: Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3. Gene. 2005 Aug 15;356:118-26. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Banfi B, Malgrange B, Knisz J, Steger K, Dubois-Dauphin M, Krause KH: NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem. 2004 Oct 29;279(44):46065-72. Epub 2004 Aug 23. [Article]
  8. Ueno N, Takeya R, Miyano K, Kikuchi H, Sumimoto H: The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators. J Biol Chem. 2005 Jun 17;280(24):23328-39. Epub 2005 Apr 11. [Article]
  9. Park HS, Park D, Bae YS: Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. Biochem Biophys Res Commun. 2006 Jan 20;339(3):985-90. [Article]
  10. Yamamoto A, Kami K, Takeya R, Sumimoto H: Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1). Biochem Biophys Res Commun. 2007 Jan 12;352(2):560-5. Epub 2006 Nov 20. [Article]
  11. Gianni D, Diaz B, Taulet N, Fowler B, Courtneidge SA, Bokoch GM: Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal. 2009 Sep 15;2(88):ra54. doi: 10.1126/scisignal.2000370. [Article]
  12. Gianni D, DerMardirossian C, Bokoch GM: Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. Eur J Cell Biol. 2011 Feb-Mar;90(2-3):164-71. doi: 10.1016/j.ejcb.2010.05.007. Epub 2010 Jul 6. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05265EcabetinvestigationalyesantagonistDetails