Retinoic acid-induced protein 3
Details
- Name
- Retinoic acid-induced protein 3
- Synonyms
- G-protein coupled receptor family C group 5 member A
- GPCR5A
- PEIG-1
- Phorbol ester induced gene 1
- RAI3
- RAIG-1
- RAIG1
- Retinoic acid-induced gene 1 protein
- Gene Name
- GPRC5A
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0016180|Retinoic acid-induced protein 3 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRW DDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAY SQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS
- Number of residues
- 357
- Molecular Weight
- 40250.69
- Theoretical pI
- 8.26
- GO Classification
- FunctionsG-protein coupled receptor activityProcessesnegative regulation of epidermal growth factor-activated receptor activity / signal transductionComponentscytoplasmic vesicle membrane / extracellular exosome / integral component of plasma membrane / intracellular membrane-bounded organelle / plasma membrane
- General Function
- G-protein coupled receptor activity
- Specific Function
- Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).
- Pfam Domain Function
- 7tm_3 (PF00003)
- Transmembrane Regions
- 34-54 69-89 98-118 130-150 177-197 213-233 248-268
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016181|Retinoic acid-induced protein 3 (GPRC5A) ATGGCTACAACAGTCCCTGATGGTTGCCGCAATGGCCTGAAATCCAAGTACTACAGACTT TGTGATAAGGCTGAAGCTTGGGGCATCGTCCTAGAAACGGTGGCCACAGCCGGGGTTGTG ACCTCGGTGGCCTTCATGCTCACTCTCCCGATCCTCGTCTGCAAGGTGCAGGACTCCAAC AGGCGAAAAATGCTGCCTACTCAGTTTCTCTTCCTCCTGGGTGTGTTGGGCATCTTTGGC CTCACCTTCGCCTTCATCATCGGACTGGACGGGAGCACAGGGCCCACACGCTTCTTCCTC TTTGGGATCCTCTTTTCCATCTGCTTCTCCTGCCTGCTGGCTCATGCTGTCAGTCTGACC AAGCTCGTCCGGGGGAGGAAGCCCCTTTCCCTGTTGGTGATTCTGGGTCTGGCCGTGGGC TTCAGCCTAGTCCAGGATGTTATCGCTATTGAATATATTGTCCTGACCATGAATAGGACC AACGTCAATGTCTTTTCTGAGCTTTCCGCTCCTCGTCGCAATGAAGACTTTGTCCTCCTG CTCACCTACGTCCTCTTCTTGATGGCGCTGACCTTCCTCATGTCCTCCTTCACCTTCTGT GGTTCCTTCACGGGCTGGAAGAGACATGGGGCCCACATCTACCTCACGATGCTCCTCTCC ATTGCCATCTGGGTGGCCTGGATCACCCTGCTCATGCTTCCTGACTTTGACCGCAGGTGG GATGACACCATCCTCAGCTCCGCCTTGGCTGCCAATGGCTGGGTGTTCCTGTTGGCTTAT GTTAGTCCCGAGTTTTGGCTGCTCACAAAGCAACGAAACCCCATGGATTATCCTGTTGAG GATGCTTTCTGTAAACCTCAACTCGTGAAGAAGAGCTATGGTGTGGAGAACAGAGCCTAC TCTCAAGAGGAAATCACTCAAGGTTTTGAAGAGACAGGGGACACGCTCTATGCCCCCTAT TCCACACATTTTCAGCTGCAGAACCAGCCTCCCCAAAAGGAATTCTCCATCCCACGGGCC CACGCTTGGCCGAGCCCTTACAAAGACTATGAAGTAAAGAAAGAGGGCAGCTAA
- Chromosome Location
- 12
- Locus
- 12p13-p12.3
- External Identifiers
Resource Link UniProtKB ID Q8NFJ5 UniProtKB Entry Name RAI3_HUMAN GenBank Protein ID 4063890 GenBank Gene ID AF095448 GenAtlas ID GPRC5A HGNC ID HGNC:9836 - General References
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