5'(3')-deoxyribonucleotidase, cytosolic type
Details
- Name
- 5'(3')-deoxyribonucleotidase, cytosolic type
- Synonyms
- 3.1.3.-
- Cytosolic 5',3'-pyrimidine nucleotidase
- Deoxy-5'-nucleotidase 1
- dNT-1
- DNT1
- UMPH2
- Gene Name
- NT5C
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008623|5'(3')-deoxyribonucleotidase, cytosolic type MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL LSWSDNWREILDSKRGAAQRE
- Number of residues
- 201
- Molecular Weight
- 23382.54
- Theoretical pI
- Not Available
- GO Classification
- Functions5'-nucleotidase activity / metal ion binding / nucleotidase activity / pyrimidine nucleotide bindingProcessesdephosphorylation / nucleobase-containing small molecule metabolic process / purine nucleobase metabolic process / purine nucleotide catabolic process / pyrimidine deoxyribonucleotide catabolic process / pyrimidine nucleobase metabolic process / pyrimidine nucleoside catabolic process / small molecule metabolic processComponentscytoplasm / cytosol / extracellular exosome / mitochondrion / nucleus
- General Function
- Pyrimidine nucleotide binding
- Specific Function
- Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
- Pfam Domain Function
- NT5C (PF06941)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0019631|5'(3')-deoxyribonucleotidase, cytosolic type (NT5C) ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGGAGGAGACCCCAAGCTGGGAGCAC ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG GAATGA
- Chromosome Location
- 17
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8TCD5 UniProtKB Entry Name NT5C_HUMAN HGNC ID HGNC:17144 - General References
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