DNA protection during starvation protein
Details
- Name
- DNA protection during starvation protein
- Synonyms
- 1.16.-.-
- Gene Name
- dps
- Organism
- Agrobacterium fabrum (strain C58 / ATCC 33970)
- Amino acid sequence
>lcl|BSEQ0011838|DNA protection during starvation protein MKTHKTKNDLPSNAKSTVIGILNESLASVIDLALVTKQAHWNLKGPQFIAVHELLDTFRT QLDNHGDTIAERVVQLGGTALGSLQAVSSTTKLKAYPTDIYKIHDHLDALIERYGEVANM IRKAIDDSDEAGDPTTADIFTAASRDLDKSLWFLEAHVQEKS
- Number of residues
- 162
- Molecular Weight
- 17822.915
- Theoretical pI
- 5.86
- GO Classification
- Functionsferric iron binding / oxidoreductase activity, oxidizing metal ionsProcessescellular iron ion homeostasis / response to stressComponentscytoplasm
- General Function
- Oxidoreductase activity, oxidizing metal ions
- Specific Function
- Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. It efficiently inhibits hydroxyl radical production by the Fenton reaction. Does not bind DNA.
- Pfam Domain Function
- Ferritin (PF00210)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011839|DNA protection during starvation protein (dps) ATGAAGACGCACAAGACGAAGAACGACCTGCCTTCCAACGCCAAGTCGACCGTGATCGGC ATTCTGAACGAATCTCTCGCCTCGGTGATCGATCTCGCGCTTGTCACCAAGCAGGCGCAC TGGAACCTGAAAGGCCCGCAATTCATCGCCGTCCACGAACTTCTCGACACCTTCCGCACC CAGCTCGACAATCACGGCGATACGATTGCCGAACGCGTCGTGCAGCTGGGCGGCACCGCA CTCGGCAGCCTGCAAGCCGTCTCCTCGACGACGAAGCTCAAGGCCTATCCGACCGATATC TATAAAATCCACGATCATCTCGACGCTCTGATCGAGCGTTATGGCGAAGTCGCCAACATG ATCCGCAAGGCGATCGACGATTCCGACGAAGCCGGCGATCCGACGACGGCCGATATCTTC ACCGCCGCCTCGCGCGATCTCGACAAGTCACTGTGGTTCCTCGAAGCCCATGTGCAGGAA AAGAGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8UCK6 UniProtKB Entry Name DPS_AGRFC GenBank Gene ID AE007869 - General References
- Wood DW, Setubal JC, Kaul R, Monks DE, Kitajima JP, Okura VK, Zhou Y, Chen L, Wood GE, Almeida NF Jr, Woo L, Chen Y, Paulsen IT, Eisen JA, Karp PD, Bovee D Sr, Chapman P, Clendenning J, Deatherage G, Gillet W, Grant C, Kutyavin T, Levy R, Li MJ, McClelland E, Palmieri A, Raymond C, Rouse G, Saenphimmachak C, Wu Z, Romero P, Gordon D, Zhang S, Yoo H, Tao Y, Biddle P, Jung M, Krespan W, Perry M, Gordon-Kamm B, Liao L, Kim S, Hendrick C, Zhao ZY, Dolan M, Chumley F, Tingey SV, Tomb JF, Gordon MP, Olson MV, Nester EW: The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science. 2001 Dec 14;294(5550):2317-23. [Article]
- Goodner B, Hinkle G, Gattung S, Miller N, Blanchard M, Qurollo B, Goldman BS, Cao Y, Askenazi M, Halling C, Mullin L, Houmiel K, Gordon J, Vaudin M, Iartchouk O, Epp A, Liu F, Wollam C, Allinger M, Doughty D, Scott C, Lappas C, Markelz B, Flanagan C, Crowell C, Gurson J, Lomo C, Sear C, Strub G, Cielo C, Slater S: Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58. Science. 2001 Dec 14;294(5550):2323-8. [Article]
- Ceci P, Ilari A, Falvo E, Chiancone E: The Dps protein of Agrobacterium tumefaciens does not bind to DNA but protects it toward oxidative cleavage: x-ray crystal structure, iron binding, and hydroxyl-radical scavenging properties. J Biol Chem. 2003 May 30;278(22):20319-26. Epub 2003 Mar 26. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details