DNA protection during starvation protein

Details

Name
DNA protection during starvation protein
Synonyms
  • 1.16.-.-
Gene Name
dps
Organism
Agrobacterium fabrum (strain C58 / ATCC 33970)
Amino acid sequence
>lcl|BSEQ0011838|DNA protection during starvation protein
MKTHKTKNDLPSNAKSTVIGILNESLASVIDLALVTKQAHWNLKGPQFIAVHELLDTFRT
QLDNHGDTIAERVVQLGGTALGSLQAVSSTTKLKAYPTDIYKIHDHLDALIERYGEVANM
IRKAIDDSDEAGDPTTADIFTAASRDLDKSLWFLEAHVQEKS
Number of residues
162
Molecular Weight
17822.915
Theoretical pI
5.86
GO Classification
Functions
ferric iron binding / oxidoreductase activity, oxidizing metal ions
Processes
cellular iron ion homeostasis / response to stress
Components
cytoplasm
General Function
Oxidoreductase activity, oxidizing metal ions
Specific Function
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. It efficiently inhibits hydroxyl radical production by the Fenton reaction. Does not bind DNA.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011839|DNA protection during starvation protein (dps)
ATGAAGACGCACAAGACGAAGAACGACCTGCCTTCCAACGCCAAGTCGACCGTGATCGGC
ATTCTGAACGAATCTCTCGCCTCGGTGATCGATCTCGCGCTTGTCACCAAGCAGGCGCAC
TGGAACCTGAAAGGCCCGCAATTCATCGCCGTCCACGAACTTCTCGACACCTTCCGCACC
CAGCTCGACAATCACGGCGATACGATTGCCGAACGCGTCGTGCAGCTGGGCGGCACCGCA
CTCGGCAGCCTGCAAGCCGTCTCCTCGACGACGAAGCTCAAGGCCTATCCGACCGATATC
TATAAAATCCACGATCATCTCGACGCTCTGATCGAGCGTTATGGCGAAGTCGCCAACATG
ATCCGCAAGGCGATCGACGATTCCGACGAAGCCGGCGATCCGACGACGGCCGATATCTTC
ACCGCCGCCTCGCGCGATCTCGACAAGTCACTGTGGTTCCTCGAAGCCCATGTGCAGGAA
AAGAGCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ8UCK6
UniProtKB Entry NameDPS_AGRFC
GenBank Gene IDAE007869
General References
  1. Wood DW, Setubal JC, Kaul R, Monks DE, Kitajima JP, Okura VK, Zhou Y, Chen L, Wood GE, Almeida NF Jr, Woo L, Chen Y, Paulsen IT, Eisen JA, Karp PD, Bovee D Sr, Chapman P, Clendenning J, Deatherage G, Gillet W, Grant C, Kutyavin T, Levy R, Li MJ, McClelland E, Palmieri A, Raymond C, Rouse G, Saenphimmachak C, Wu Z, Romero P, Gordon D, Zhang S, Yoo H, Tao Y, Biddle P, Jung M, Krespan W, Perry M, Gordon-Kamm B, Liao L, Kim S, Hendrick C, Zhao ZY, Dolan M, Chumley F, Tingey SV, Tomb JF, Gordon MP, Olson MV, Nester EW: The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science. 2001 Dec 14;294(5550):2317-23. [Article]
  2. Goodner B, Hinkle G, Gattung S, Miller N, Blanchard M, Qurollo B, Goldman BS, Cao Y, Askenazi M, Halling C, Mullin L, Houmiel K, Gordon J, Vaudin M, Iartchouk O, Epp A, Liu F, Wollam C, Allinger M, Doughty D, Scott C, Lappas C, Markelz B, Flanagan C, Crowell C, Gurson J, Lomo C, Sear C, Strub G, Cielo C, Slater S: Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58. Science. 2001 Dec 14;294(5550):2323-8. [Article]
  3. Ceci P, Ilari A, Falvo E, Chiancone E: The Dps protein of Agrobacterium tumefaciens does not bind to DNA but protects it toward oxidative cleavage: x-ray crystal structure, iron binding, and hydroxyl-radical scavenging properties. J Biol Chem. 2003 May 30;278(22):20319-26. Epub 2003 Mar 26. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails