Histone deacetylase 7

Details

Name
Histone deacetylase 7
Synonyms
  • 3.5.1.98
  • HD7
  • HD7a
  • HDAC7A
  • Histone deacetylase 7A
Gene Name
HDAC7
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006797|Histone deacetylase 7
MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVG
PQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPL
ETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKE
SAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSV
APFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGG
TLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEP
LPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVV
DDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRP
LSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSR
HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD
NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG
FAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQ
DPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRI
VVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALE
GGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQR
LASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
Number of residues
952
Molecular Weight
102926.225
Theoretical pI
7.6
GO Classification
Functions
14-3-3 protein binding / activating transcription factor binding / chromatin binding / metal ion binding / NAD-dependent histone deacetylase activity (H3-K14 specific) / protein kinase binding / protein kinase C binding / repressing transcription factor binding / transcription corepressor activity
Processes
cell-cell junction assembly / cellular protein metabolic process / negative regulation of interleukin-2 production / negative regulation of NIK/NF-kappaB signaling / negative regulation of osteoblast differentiation / negative regulation of transcription from RNA polymerase II promoter / Notch signaling pathway / positive regulation of cell migration involved in sprouting angiogenesis / post-translational protein modification / protein sumoylation / transcription, DNA-templated / vasculogenesis
Components
cytoplasm / histone deacetylase complex / nucleoplasm / nucleus
General Function
Transcription corepressor activity
Specific Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0012455|Histone deacetylase 7 (HDAC7)
ATGCACAGCCCCGGCGCTGATGGGACCCAGGTGAGCCCGGGTGCCCACTACTGCAGCCCC
ACTGGCGCAGGCTGCCCCAGGCCCTGTGCAGACACACCAGGCCCTCAGCCGCAGCCCATG
GACCTGCGGGTGGGCCAGCGGCCCCCAGTGGAGCCCCCACCAGAGCCCACATTGCTGGCC
CTGCAGCGTCCCCAGCGCCTGCACCACCACCTCTTCCTAGCAGGCCTGCAGCAGCAGCGC
TCGGTGGAGCCCATGAGGCTCTCCATGGACACGCCGATGCCCGAGTTGCAGGTGGGACCC
CAGGAACAAGAGCTGCGGCAGCTTCTCCACAAGGACAAGAGCAAGCGAAGTGCTGTAGCC
AGCAGCGTGGTCAAGCAGAAGCTAGCGGAGGTGATTCTGAAAAAACAGCAGGCGGCCCTA
GAAAGAACAGTCCATCCCAACAGCCCCGGCATTCCCTACAGAACCCTGGAGCCCCTGGAG
ACGGAAGGAGCCACCCGCTCCATGCTCAGCAGCTTTTTGCCTCCTGTTCCCAGCCTGCCC
AGTGACCCCCCAGAGCACTTCCCTCTGCGCAAGACAGTCTCTGAGCCCAACCTGAAGCTG
CGCTATAAGCCCAAGAAGTCCCTGGAGCGGAGGAAGAATCCACTGCTCCGAAAGGAGAGT
GCGCCCCCCAGCCTCCGGCGGCGGCCCGCAGAGACCCTCGGAGACTCCTCCCCAAGTAGT
AGCAGCACGCCCGCATCAGGGTGCAGCTCCCCCAATGACAGCGAGCACGGCCCCAATCCC
ATCCTGGGCTCGGAGGCTGACAGTGACCGCAGGACCCATCCGACTCTGGGCCCTCGGGGG
CCAATCCTGGGGAGCCCCCACACTCCCCTCTTCCTGCCCCATGGCTTGGAGCCCGAGGCT
GGGGGCACCTTGCCCTCTCGCCTGCAGCCCATTCTCCTCCTGGACCCCTCAGGCTCTCAT
GCCCCGCTGCTGACTGTGCCCGGGCTTGGGCCCTTGCCCTTCCACTTTGCCCAGTCCTTA
ATGACCACCGAGCGGCTCTCTGGGTCAGGCCTCCACTGGCCACTGAGCCGGACTCGCTCA
GAGCCCCTGCCCCCCAGTGCCACCGCTCCCCCACCGCCGGGCCCCATGCAGCCCCGCCTG
GAGCAGCTCAAAACTCACGTCCAGGTGATCAAGAGGTCAGCCAAGCCGAGTGAGAAGCCC
CGGCTGCGGCAGATACCCTCGGCTGAAGACCTGGAGACAGATGGCGGGGGACCGGGCCAG
GTGGTGGACGATGGCCTGGAGCACAGGGAGCTGGGCCATGGGCAGCCTGAGGCCAGAGGC
CCCGCTCCTCTCCAGCAGCACCCTCAGGTGTTGCTCTGGGAACAGCAGCGACTGGCTGGG
CGGCTCCCCCGGGGCAGCACCGGGGACACTGTGCTGCTTCCTCTGGCCCAGGGTGGGCAC
CGGCCTCTGTCCCGGGCTCAGTCTTCCCCAGCCGCACCTGCCTCACTGTCAGCCCCAGAG
CCTGCCAGCCAGGCCCGAGTCCTCTCCAGCTCAGAGACCCCTGCCAGGACCCTGCCCTTC
ACCACAGGGCTGATCTATGACTCGGTCATGCTGAAGCACCAGTGCTCCTGCGGTGACAAC
AGCAGGCACCCGGAGCACGCCGGCCGCATCCAGAGCATCTGGTCCCGGCTGCAGGAGCGG
GGGCTCCGGAGCCAGTGTGAGTGTCTCCGAGGCCGGAAGGCCTCCCTGGAAGAGCTGCAG
TCGGTCCACTCTGAGCGGCACGTGCTCCTCTACGGCACCAACCCGCTCAGCCGCCTCAAA
CTGGACAACGGGAAGCTGGCAGGGCTCCTGGCACAGCGGATGTTTGTGATGCTGCCCTGT
GGTGGGGTTGGGGTGGACACTGACACCATCTGGAATGAGCTTCATTCCTCCAATGCAGCC
CGCTGGGCCGCTGGCAGTGTCACTGACCTCGCCTTCAAAGTGGCTTCTCGTGAGCTAAAG
AATGGTTTCGCTGTGGTGCGGCCCCCAGGACACCATGCAGATCATTCAACAGCCATGGGC
TTCTGCTTCTTCAACTCAGTGGCCATCGCCTGCCGGCAGCTGCAACAGCAGAGCAAGGCC
AGCAAGATCCTCATTGTAGACTGGGACGTGCACCATGGCAACGGCACCCAGCAAACCTTC
TACCAAGACCCCAGTGTGCTCTACATCTCCCTGCATCGCCATGACGACGGCAACTTCTTC
CCGGGGAGTGGGGCTGTGGATGAGGTAGGGGCTGGCAGCGGTGAGGGCTTCAATGTCAAT
GTGGCCTGGGCTGGAGGTCTGGACCCCCCCATGGGGGATCCTGAGTACCTGGCTGCTTTC
AGGATAGTCGTGATGCCCATCGCCCGAGAGTTCTCTCCAGACCTAGTCCTGGTGTCTGCT
GGATTTGATGCTGCTGAGGGTCACCCGGCCCCACTGGGTGGCTACCATGTTTCTGCCAAA
TGTTTTGGATACATGACGCAGCAACTGATGAACCTGGCAGGAGGCGCAGTGGTGCTGGCC
TTGGAGGGTGGCCATGACCTCACAGCCATCTGTGACGCCTCTGAGGCCTGTGTGGCTGCT
CTTCTGGGTAACAGGGTGGATCCCCTTTCAGAAGAAGGCTGGAAACAGAAACCCAACCTC
AATGCCATCCGCTCTCTGGAGGCCGTGATCCGGGTGCACAGTAAATACTGGGGCTGCATG
CAGCGCCTGGCCTCCTGTCCAGACTCCTGGGTGCCTAGAGTGCCAGGGGCTGACAAAGAA
GAAGTGGAGGCAGTGACCGCACTGGCGTCCCTCTCTGTGGGCATCCTGGCTGAAGATAGG
CCCTCGGAGCAGCTGGTGGAGGAGGAAGAACCTATGAATCTCTAA
Chromosome Location
12
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ8WUI4
UniProtKB Entry NameHDAC7_HUMAN
GenBank Gene IDBC020505
GenAtlas IDHDAC7
HGNC IDHGNC:14067
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04297Trichostatin AexperimentalunknownDetails
DB05015Belinostatapproved, investigationalyesinhibitorDetails
DB06603Panobinostatapproved, investigationalyesinhibitorDetails
DB02546Vorinostatapproved, investigationalunknowninhibitorDetails
DB12847PyroxamideinvestigationalunknowninhibitorDetails
DB00313Valproic acidapproved, investigationalunknowninhibitorDetails
DB11841EntinostatinvestigationalyesinhibitorDetails
DB06819Phenylbutyric acidapproved, investigationalunknowninhibitorDetails
DB12645GivinostatinvestigationalunknowninhibitorDetails
DB06176Romidepsinapproved, investigationalunknowninhibitorDetails
DB01262Decitabineapproved, investigationalunknowninhibitorDetails
DB12565AbexinostatinvestigationalunknowninhibitorDetails
DB03766Propanoic acidapproved, vet_approvedunknowninhibitorDetails