Solute carrier family 13 member 3
Details
- Name
- Solute carrier family 13 member 3
- Synonyms
- hNaDC3
- Na(+)/dicarboxylate cotransporter 3
- NaDC-3
- NADC3
- SDCT2
- Sodium-dependent high-affinity dicarboxylate transporter 2
- Gene Name
- SLC13A3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001219|Solute carrier family 13 member 3 MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLS VTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLV GVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENT AAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPY SASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFL YGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRD PKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKK AQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTE FASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLL VKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFR TL
- Number of residues
- 602
- Molecular Weight
- 66840.355
- Theoretical pI
- 8.47
- GO Classification
- Functionscitrate transmembrane transporter activity / high-affinity sodium / L-aspartate transmembrane transporter activity / sodium / succinate transmembrane transporter activityProcessescitrate transport / succinate transmembrane transport / transmembrane transportComponentsextracellular exosome / integral component of plasma membrane / plasma membrane
- General Function
- Succinate transmembrane transporter activity
- Specific Function
- High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate.
- Pfam Domain Function
- Na_sulph_symp (PF00939)
- Transmembrane Regions
- 17-37 56-76 83-103 138-158 230-250 279-299 337-357 373-393 462-482 506-526 547-567
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0018981|Solute carrier family 13 member 3 (SLC13A3) ATGGCGGTGTACTGGTGCACGGAGGCCCTGCCGCTCTCAGTGACGGCGCTGCTGCCCATC GTCCTCTTCCCCTTCATGGGCATCTTGCCCTCCAACAAGGTCTGCCCCCAGTACTTCCTC GACACCAACTTCCTCTTCCTCAGTGGGCTGATCATGGCCAGCGCCATTGAGGAGTGGAAC CTGCACCGGCGAATCGCCCTCAAGATCCTGATGCTTGTTGGAGTCCAGCCGGCCAGGCTC ATCCTGGGGATGATGGTGACCACCTCGTTCTTGTCCATGTGGCTGAGCAACACCGCCTCC ACTGCCATGATGCTTCCCATTGCCAATGCCATCCTGAAAAGTCTCTTTGGCCAGAAGGAG GTTCGAAAGGACCCCAGCCAGGAGAGTGAAGAGAACACAGCTGCTGTGCGGAGAAACGGC CTACACACTGTGCCCACGGAGATGCAGTTTCTCGCCAGCACAGAAGCCAAAGACCACCCT GGGGAGACAGAGGTTCCACTGGATCTGCCGGCTGACTCCAGGAAGGAGGATGAATATCGT CGGAACATCTGGAAGGGCTTCCTCATCTCCATCCCCTACTCAGCCAGTATTGGGGGCACA GCCACACTCACGGGCACAGCCCCTAACCTCATCCTGCTTGGCCAGCTCAAGAGTTTCTTT CCGCAGTGTGACGTGGTGAATTTCGGCTCCTGGTTCATTTTCGCCTTCCCTCTTATGCTG TTGTTCCTGTTGGCAGGCTGGCTCTGGATCTCCTTCCTGTACGGGGGACTGAGCTTCAGG GGCTGGAGGAAGAATAAATCTGAGATAAGAACCAATGCAGAAGATAGGGCTCGAGCTGTA ATTCGGGAAGAATACCAGAACCTGGGGCCCATCAAGTTTGCCGAACAGGCTGTTTTCATC CTTTTCTGCATGTTTGCCATCCTCCTCTTCACCCGGGACCCGAAGTTCATCCCTGGCTGG GCCAGCCTCTTCAATCCTGGGTTTCTTTCTGATGCTGTCACCGGCGTGGCTATTGTCACC ATCTTGTTCTTCTTCCCGTCCCAAAGGCCCTCTCTCAAGTGGTGGTTTGACTTCAAAGCT CCCAACACAGAGACAGAGCCCTTGCTGACCTGGAAGAAGGCCCAGGAGACAGTGCCCTGG AACATCATCCTTCTCCTGGGAGGGGGCTTCGCCATGGCCAAAGGCTGTGAGGAATCGGGG CTGTCTGTATGGATTGGTGGGCAGCTGCACCCCCTGGAGAATGTGCCCCCCGCCCTGGCT GTGCTGCTCATCACTGTGGTCATCGCCTTCTTCACTGAGTTTGCCAGCAACACGGCGACC ATCATCATCTTCCTGCCGGTCCTGGCAGAGCTGGCCATCCGCCTGAGAGTGCACCCCCTG TATCTGATGATTCCGGGCACAGTCGGCTGCTCCTTTGCCTTCATGCTCCCGGTCTCAACG CCCCCCAACTCCATCGCCTTCGCCTCTGGACACTTGCTGGTCAAAGACATGGTGCGGACA GGCCTCCTGATGAACCTGATGGGTGTCCTGCTGCTCAGTTTGGCTATGAATACCTGGGCA CAGACCATCTTCCAGCTGGGCACCTTCCCGGACTGGGCTGATATGTACTCGGTCAATGTC ACAGCATTGCCACCCACCTTGGCCAATGACACATTTCGGACCCTCTGA
- Chromosome Location
- 20
- Locus
- 20q12-q13.1
- External Identifiers
Resource Link UniProtKB ID Q8WWT9 UniProtKB Entry Name S13A3_HUMAN GenBank Protein ID 8132324 GenBank Gene ID AF154121 GenAtlas ID SLC13A3 HGNC ID HGNC:14430 - General References
- Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V: Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter. Am J Physiol Cell Physiol. 2000 May;278(5):C1019-30. [Article]
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