ATP-binding cassette sub-family A member 5

Details

Name
ATP-binding cassette sub-family A member 5
Synonyms
  • KIAA1888
Gene Name
ABCA5
Organism
Humans
Amino acid sequence
>lcl|BSEQ0007053|ATP-binding cassette sub-family A member 5
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE
VPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSL
SKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI
VAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIF
LLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQV
IPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRI
SGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL
DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYR
KANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTT
LEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLW
KQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLY
FLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVM
HSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIE
LYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFII
LILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFI
YSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDT
YNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPD
NEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS
FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCP
QINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRK
LCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVC
DRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQ
ESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEED
NSCGTLNSTLWWERTQEDRVVF
Number of residues
1642
Molecular Weight
186505.825
Theoretical pI
6.94
GO Classification
Functions
ATP binding / ATPase activity, coupled to transmembrane movement of substances
Processes
cholesterol efflux / high-density lipoprotein particle remodeling / lipid transport / negative regulation of macrophage derived foam cell differentiation / reverse cholesterol transport / transmembrane transport
Components
Golgi membrane / integral component of membrane / intracellular membrane-bounded organelle / late endosome / late endosome membrane / lysosomal membrane / lysosome
General Function
Atpase activity, coupled to transmembrane movement of substances
Specific Function
May play a role in the processing of autolysosomes.
Pfam Domain Function
Transmembrane Regions
32-52 220-240 264-284 297-317 328-348 355-375 396-416 866-886 967-987 1021-1041 1071-1091 1102-1122 1139-1159 1169-1189 1207-1227
Cellular Location
Lysosome membrane
Gene sequence
>lcl|BSEQ0021367|ATP-binding cassette sub-family A member 5 (ABCA5)
ATGTCCACTGCAATTAGGGAGGTAGGAGTTTGGAGACAGACCAGAACACTTCTACTGAAG
AATTACTTAATTAAATGCAGAACCAAAAAGAGTAGTGTTCAGGAAATTCTTTTTCCACTA
TTTTTTTTATTTTGGTTAATATTAATTAGCATGATGCATCCAAATAAGAAATATGAAGAA
GTGCCTAATATAGAACTCAATCCTATGGACAAGTTTACTCTTTCTAATCTAATTCTTGGA
TATACTCCAGTGACTAATATTACAAGCAGCATCATGCAGAAAGTGTCTACTGATCATCTA
CCTGATGTCATAATTACTGAAGAATATACAAATGAAAAAGAAATGTTAACATCCAGTCTC
TCTAAGCCGAGCAACTTTGTAGGTGTGGTTTTCAAAGACTCCATGTCCTATGAACTTCGT
TTTTTTCCTGATATGATTCCAGTATCTTCTATTTATATGGATTCAAGAGCTGGCTGTTCA
AAATCATGTGAGGCTGCTCAGTACTGGTCCTCAGGTTTCACAGTTTTACAAGCATCCATA
GATGCTGCCATTATACAGTTGAAGACCAATGTTTCTCTTTGGAAGGAGCTGGAGTCAACT
AAAGCTGTTATTATGGGAGAAACTGCTGTTGTAGAAATAGATACCTTTCCCCGAGGAGTA
ATTTTAATATACCTAGTTATAGCATTTTCACCTTTTGGATACTTTTTGGCAATTCATATC
GTAGCAGAAAAAGAAAAAAAAATAAAAGAATTTTTAAAGATAATGGGACTTCATGATACT
GCCTTTTGGCTTTCCTGGGTTCTTCTATATACAAGTTTAATTTTTCTTATGTCCCTTCTT
ATGGCAGTCATTGCGACAGCTTCTTTGTTATTTCCTCAAAGTAGCAGCATTGTGATATTT
CTGCTTTTTTTCCTTTATGGATTATCATCTGTATTTTTTGCTTTAATGCTGACACCTCTT
TTTAAAAAATCAAAACATGTGGGAATAGTTGAATTTTTTGTTACTGTGGCTTTTGGATTT
ATTGGCCTTATGATAATCCTCATAGAAAGTTTTCCCAAATCGTTAGTGTGGCTTTTCAGT
CCTTTCTGTCACTGTACTTTTGTGATTGGTATTGCACAGGTCATGCATTTAGAAGATTTT
AATGAAGGTGCTTCATTTTCAAATTTGACTGCAGGCCCATATCCTCTAATTATTACAATT
ATCATGCTCACACTTAATAGTATATTCTATGTCCTCTTGGCTGTCTATCTTGATCAAGTC
ATTCCAGGGGAATTTGGCTTACGGAGATCATCTTTATATTTTCTGAAGCCTTCATATTGG
TCAAAGAGCAAAAGAAATTATGAGGAGTTATCAGAGGGCAATGTTAATGGAAATATTAGT
TTTAGTGAAATTATTGAGCCAGTTTCTTCAGAATTTGTAGGAAAAGAAGCCATAAGAATT
AGTGGTATTCAGAAGACATACAGAAAGAAGGGTGAAAATGTGGAGGCTTTGAGAAATTTG
TCATTTGACATATATGAGGGTCAGATTACTGCCTTACTTGGCCACAGTGGAACAGGAAAG
AGTACATTGATGAATATTCTTTGTGGACTCTGCCCACCTTCTGATGGGTTTGCATCTATA
TATGGACACAGAGTCTCAGAAATAGATGAAATGTTTGAAGCAAGAAAAATGATTGGCATT
TGTCCACAGTTAGATATACACTTTGATGTTTTGACAGTAGAAGAAAATTTATCAATTTTG
GCTTCAATCAAAGGGATACCAGCCAACAATATAATACAAGAAGTGCAGAAGGTTTTACTA
GATTTAGACATGCAGACTATCAAAGATAACCAAGCTAAAAAATTAAGTGGTGGTCAAAAA
AGAAAGCTGTCATTAGGAATTGCTGTTCTTGGGAACCCAAAGATACTGCTGCTAGATGAA
CCAACAGCTGGAATGGACCCCTGTTCTCGACATATTGTATGGAATCTTTTAAAATACAGA
AAAGCCAATCGGGTGACAGTGTTCAGTACTCATTTCATGGATGAAGCTGACATTCTTGCA
GATAGGAAAGCTGTGATATCACAAGGAATGCTGAAATGTGTTGGTTCTTCAATGTTCCTC
AAAAGTAAATGGGGGATCGGCTACCGCCTGAGCATGTACATAGACAAATATTGTGCCACA
GAATCTCTTTCTTCACTGGTTAAACAACATATACCTGGAGCTACTTTATTACAACAGAAT
GACCAACAACTTGTGTATAGCTTGCCTTTCAAGGACATGGACAAATTTTCAGGTTTGTTT
TCTGCCCTAGACAGTCATTCAAATTTGGGTGTCATTTCTTATGGTGTTTCCATGACGACT
TTGGAAGACGTATTTTTAAAGCTAGAAGTTGAAGCAGAAATTGACCAAGCAGATTATAGT
GTATTTACTCAGCAGCCACTGGAGGAAGAAATGGATTCAAAATCTTTTGATGAAATGGAA
CAGAGCTTACTTATTCTTTCTGAAACCAAGGCTGCTCTAGTGAGCACCATGAGCCTTTGG
AAACAACAGATGTATACAATAGCAAAGTTTCATTTCTTTACCTTGAAACGTGAAAGTAAA
TCAGTGAGATCAGTGTTGCTTCTGCTTTTAATTTTTTTCACAGTTCAGATTTTTATGTTT
TTGGTTCATCACTCTTTTAAAAATGCTGTGGTTCCCATCAAACTTGTTCCAGACTTATAT
TTTCTAAAACCTGGAGACAAACCACATAAATACAAAACAAGTCTGCTTCTTCAAAATTCT
GCTGACTCAGATATCAGTGATCTTATTAGCTTTTTCACAAGCCAGAACATAATGGTGACG
ATGATTAATGACAGTGACTATGTATCCGTGGCTCCCCATAGTGCGGCTTTAAATGTGATG
CATTCAGAAAAGGACTATGTTTTTGCAGCTGTTTTCAACAGTACTATGGTTTATTCTTTA
CCTATATTAGTGAATATCATTAGTAACTACTATCTTTATCATTTAAATGTGACTGAAACC
ATCCAGATCTGGAGTACCCCATTCTTTCAAGAAATTACTGATATAGTTTTTAAAATTGAG
CTGTATTTTCAAGCAGCTTTGCTTGGAATCATTGTTACTGCAATGCCACCTTACTTTGCC
ATGGAAAATGCAGAGAATCATAAGATCAAAGCTTATACTCAACTTAAACTTTCAGGTCTT
TTGCCATCTGCATATTGGATTGGACAAGCTGTTGTTGATATCCCCTTATTTTTTATCATT
CTTATTTTGATGCTAGGAAGCTTATTGGCATTTCATTATGGATTATATTTTTATACTGTA
AAGTTCCTTGCTGTGGTTTTTTGCCTTATTGGTTATGTTCCATCAGTTATTCTGTTCACT
TATATTGCTTCTTTCACCTTTAAGAAAATTTTAAATACCAAAGAATTTTGGTCATTTATC
TATTCTGTGGCAGCGTTGGCTTGTATTGCAATCACTGAAATAACTTTCTTTATGGGATAC
ACAATTGCAACTATTCTTCATTATGCCTTTTGTATCATCATTCCAATCTATCCACTTCTA
GGTTGCCTGATTTCTTTCATAAAGATTTCTTGGAAGAATGTACGAAAAAATGTGGACACC
TATAATCCATGGGATAGGCTTTCAGTAGCTGTTATATCGCCTTACCTGCAGTGTGTACTG
TGGATTTTCCTCTTACAATACTATGAGAAAAAATATGGAGGCAGATCAATAAGAAAAGAT
CCCTTTTTCAGAAACCTTTCAACGAAGTCTAAAAATAGGAAGCTTCCAGAACCACCAGAC
AATGAGGATGAAGATGAAGATGTCAAAGCTGAAAGACTAAAGGTCAAAGAGCTGATGGGT
TGCCAGTGTTGTGAGGAGAAACCATCCATTATGGTCAGCAATTTGCATAAAGAATATGAT
GACAAGAAAGATTTTCTTCTTTCAAGAAAAGTAAAGAAAGTGGCAACTAAATACATCTCT
TTCTGTGTGAAAAAAGGAGAGATCTTAGGACTATTGGGTCCAAATGGTGCTGGCAAAAGC
ACAATTATTAATATTCTGGTTGGTGATATTGAACCAACTTCAGGCCAGGTATTTTTAGGA
GATTATTCTTCAGAGACAAGTGAAGATGATGATTCACTGAAGTGTATGGGTTACTGTCCT
CAGATAAACCCTTTGTGGCCAGATACTACATTGCAGGAACATTTTGAAATTTATGGAGCT
GTCAAAGGAATGAGTGCAAGTGACATGAAAGAAGTCATAAGTCGAATAACACATGCACTT
GATTTAAAAGAACATCTTCAGAAGACTGTAAAGAAACTACCTGCAGGAATCAAACGAAAG
TTGTGTTTTGCTCTAAGTATGCTAGGGAATCCTCAGATTACTTTGCTAGATGAACCATCT
ACAGGTATGGATCCCAAAGCCAAACAGCACATGTGGCGAGCAATTCGAACTGCATTTAAA
AACAGAAAGCGGGCTGCTATTCTGACCACTCACTATATGGAGGAGGCAGAGGCTGTCTGT
GATCGAGTAGCTATCATGGTGTCTGGGCAGTTAAGATGTATCGGAACAGTACAACATCTA
AAGAGTAAATTTGGAAAAGGCTACTTTTTGGAAATTAAATTGAAGGACTGGATAGAAAAC
CTAGAAGTAGACCGCCTTCAAAGAGAAATTCAGTATATTTTCCCAAATGCAAGCCGTCAG
GAAAGTTTTTCTTCTATTTTGGCTTATAAAATTCCTAAGGAAGATGTTCAGTCCCTTTCA
CAATCTTTTTTTAAGCTGGAAGAAGCTAAACATGCTTTTGCCATTGAAGAATATAGCTTT
TCTCAAGCAACATTGGAACAGGTTTTTGTAGAACTCACTAAAGAACAAGAGGAGGAAGAT
AATAGTTGTGGAACTTTAAACAGCACACTTTGGTGGGAACGAACACAAGAAGATAGAGTA
GTATTTTGA
Chromosome Location
17
Locus
17q24.3
External Identifiers
ResourceLink
UniProtKB IDQ8WWZ7
UniProtKB Entry NameABCA5_HUMAN
GenBank Protein ID17223620
GenBank Gene IDAY028897
HGNC IDHGNC:35
General References
  1. Petry F, Kotthaus A, Hirsch-Ernst KI: Cloning of human and rat ABCA5/Abca5 and detection of a human splice variant. Biochem Biophys Res Commun. 2003 Jan 10;300(2):343-50. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Nagase T, Kikuno R, Ohara O: Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. DNA Res. 2001 Aug 31;8(4):179-87. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00864Tacrolimusapproved, investigationalunknownsubstrateDetails