ATP-binding cassette sub-family A member 5
Details
- Name
- ATP-binding cassette sub-family A member 5
- Synonyms
- KIAA1888
- Gene Name
- ABCA5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007053|ATP-binding cassette sub-family A member 5 MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE VPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSL SKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI VAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIF LLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQV IPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRI SGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYR KANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTT LEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLW KQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLY FLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVM HSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIE LYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFII LILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFI YSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDT YNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPD NEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCP QINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRK LCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVC DRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQ ESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEED NSCGTLNSTLWWERTQEDRVVF
- Number of residues
- 1642
- Molecular Weight
- 186505.825
- Theoretical pI
- 6.94
- GO Classification
- FunctionsATP binding / ATPase activity, coupled to transmembrane movement of substancesProcessescholesterol efflux / high-density lipoprotein particle remodeling / lipid transport / negative regulation of macrophage derived foam cell differentiation / reverse cholesterol transport / transmembrane transportComponentsGolgi membrane / integral component of membrane / intracellular membrane-bounded organelle / late endosome / late endosome membrane / lysosomal membrane / lysosome
- General Function
- Atpase activity, coupled to transmembrane movement of substances
- Specific Function
- May play a role in the processing of autolysosomes.
- Pfam Domain Function
- ABC_tran (PF00005)
- Transmembrane Regions
- 32-52 220-240 264-284 297-317 328-348 355-375 396-416 866-886 967-987 1021-1041 1071-1091 1102-1122 1139-1159 1169-1189 1207-1227
- Cellular Location
- Lysosome membrane
- Gene sequence
>lcl|BSEQ0021367|ATP-binding cassette sub-family A member 5 (ABCA5) ATGTCCACTGCAATTAGGGAGGTAGGAGTTTGGAGACAGACCAGAACACTTCTACTGAAG AATTACTTAATTAAATGCAGAACCAAAAAGAGTAGTGTTCAGGAAATTCTTTTTCCACTA TTTTTTTTATTTTGGTTAATATTAATTAGCATGATGCATCCAAATAAGAAATATGAAGAA GTGCCTAATATAGAACTCAATCCTATGGACAAGTTTACTCTTTCTAATCTAATTCTTGGA TATACTCCAGTGACTAATATTACAAGCAGCATCATGCAGAAAGTGTCTACTGATCATCTA CCTGATGTCATAATTACTGAAGAATATACAAATGAAAAAGAAATGTTAACATCCAGTCTC TCTAAGCCGAGCAACTTTGTAGGTGTGGTTTTCAAAGACTCCATGTCCTATGAACTTCGT TTTTTTCCTGATATGATTCCAGTATCTTCTATTTATATGGATTCAAGAGCTGGCTGTTCA AAATCATGTGAGGCTGCTCAGTACTGGTCCTCAGGTTTCACAGTTTTACAAGCATCCATA GATGCTGCCATTATACAGTTGAAGACCAATGTTTCTCTTTGGAAGGAGCTGGAGTCAACT AAAGCTGTTATTATGGGAGAAACTGCTGTTGTAGAAATAGATACCTTTCCCCGAGGAGTA ATTTTAATATACCTAGTTATAGCATTTTCACCTTTTGGATACTTTTTGGCAATTCATATC GTAGCAGAAAAAGAAAAAAAAATAAAAGAATTTTTAAAGATAATGGGACTTCATGATACT GCCTTTTGGCTTTCCTGGGTTCTTCTATATACAAGTTTAATTTTTCTTATGTCCCTTCTT ATGGCAGTCATTGCGACAGCTTCTTTGTTATTTCCTCAAAGTAGCAGCATTGTGATATTT CTGCTTTTTTTCCTTTATGGATTATCATCTGTATTTTTTGCTTTAATGCTGACACCTCTT TTTAAAAAATCAAAACATGTGGGAATAGTTGAATTTTTTGTTACTGTGGCTTTTGGATTT ATTGGCCTTATGATAATCCTCATAGAAAGTTTTCCCAAATCGTTAGTGTGGCTTTTCAGT CCTTTCTGTCACTGTACTTTTGTGATTGGTATTGCACAGGTCATGCATTTAGAAGATTTT AATGAAGGTGCTTCATTTTCAAATTTGACTGCAGGCCCATATCCTCTAATTATTACAATT ATCATGCTCACACTTAATAGTATATTCTATGTCCTCTTGGCTGTCTATCTTGATCAAGTC ATTCCAGGGGAATTTGGCTTACGGAGATCATCTTTATATTTTCTGAAGCCTTCATATTGG TCAAAGAGCAAAAGAAATTATGAGGAGTTATCAGAGGGCAATGTTAATGGAAATATTAGT TTTAGTGAAATTATTGAGCCAGTTTCTTCAGAATTTGTAGGAAAAGAAGCCATAAGAATT AGTGGTATTCAGAAGACATACAGAAAGAAGGGTGAAAATGTGGAGGCTTTGAGAAATTTG TCATTTGACATATATGAGGGTCAGATTACTGCCTTACTTGGCCACAGTGGAACAGGAAAG AGTACATTGATGAATATTCTTTGTGGACTCTGCCCACCTTCTGATGGGTTTGCATCTATA TATGGACACAGAGTCTCAGAAATAGATGAAATGTTTGAAGCAAGAAAAATGATTGGCATT TGTCCACAGTTAGATATACACTTTGATGTTTTGACAGTAGAAGAAAATTTATCAATTTTG GCTTCAATCAAAGGGATACCAGCCAACAATATAATACAAGAAGTGCAGAAGGTTTTACTA GATTTAGACATGCAGACTATCAAAGATAACCAAGCTAAAAAATTAAGTGGTGGTCAAAAA AGAAAGCTGTCATTAGGAATTGCTGTTCTTGGGAACCCAAAGATACTGCTGCTAGATGAA CCAACAGCTGGAATGGACCCCTGTTCTCGACATATTGTATGGAATCTTTTAAAATACAGA AAAGCCAATCGGGTGACAGTGTTCAGTACTCATTTCATGGATGAAGCTGACATTCTTGCA GATAGGAAAGCTGTGATATCACAAGGAATGCTGAAATGTGTTGGTTCTTCAATGTTCCTC AAAAGTAAATGGGGGATCGGCTACCGCCTGAGCATGTACATAGACAAATATTGTGCCACA GAATCTCTTTCTTCACTGGTTAAACAACATATACCTGGAGCTACTTTATTACAACAGAAT GACCAACAACTTGTGTATAGCTTGCCTTTCAAGGACATGGACAAATTTTCAGGTTTGTTT TCTGCCCTAGACAGTCATTCAAATTTGGGTGTCATTTCTTATGGTGTTTCCATGACGACT TTGGAAGACGTATTTTTAAAGCTAGAAGTTGAAGCAGAAATTGACCAAGCAGATTATAGT GTATTTACTCAGCAGCCACTGGAGGAAGAAATGGATTCAAAATCTTTTGATGAAATGGAA CAGAGCTTACTTATTCTTTCTGAAACCAAGGCTGCTCTAGTGAGCACCATGAGCCTTTGG AAACAACAGATGTATACAATAGCAAAGTTTCATTTCTTTACCTTGAAACGTGAAAGTAAA TCAGTGAGATCAGTGTTGCTTCTGCTTTTAATTTTTTTCACAGTTCAGATTTTTATGTTT TTGGTTCATCACTCTTTTAAAAATGCTGTGGTTCCCATCAAACTTGTTCCAGACTTATAT TTTCTAAAACCTGGAGACAAACCACATAAATACAAAACAAGTCTGCTTCTTCAAAATTCT GCTGACTCAGATATCAGTGATCTTATTAGCTTTTTCACAAGCCAGAACATAATGGTGACG ATGATTAATGACAGTGACTATGTATCCGTGGCTCCCCATAGTGCGGCTTTAAATGTGATG CATTCAGAAAAGGACTATGTTTTTGCAGCTGTTTTCAACAGTACTATGGTTTATTCTTTA CCTATATTAGTGAATATCATTAGTAACTACTATCTTTATCATTTAAATGTGACTGAAACC ATCCAGATCTGGAGTACCCCATTCTTTCAAGAAATTACTGATATAGTTTTTAAAATTGAG CTGTATTTTCAAGCAGCTTTGCTTGGAATCATTGTTACTGCAATGCCACCTTACTTTGCC ATGGAAAATGCAGAGAATCATAAGATCAAAGCTTATACTCAACTTAAACTTTCAGGTCTT TTGCCATCTGCATATTGGATTGGACAAGCTGTTGTTGATATCCCCTTATTTTTTATCATT CTTATTTTGATGCTAGGAAGCTTATTGGCATTTCATTATGGATTATATTTTTATACTGTA AAGTTCCTTGCTGTGGTTTTTTGCCTTATTGGTTATGTTCCATCAGTTATTCTGTTCACT TATATTGCTTCTTTCACCTTTAAGAAAATTTTAAATACCAAAGAATTTTGGTCATTTATC TATTCTGTGGCAGCGTTGGCTTGTATTGCAATCACTGAAATAACTTTCTTTATGGGATAC ACAATTGCAACTATTCTTCATTATGCCTTTTGTATCATCATTCCAATCTATCCACTTCTA GGTTGCCTGATTTCTTTCATAAAGATTTCTTGGAAGAATGTACGAAAAAATGTGGACACC TATAATCCATGGGATAGGCTTTCAGTAGCTGTTATATCGCCTTACCTGCAGTGTGTACTG TGGATTTTCCTCTTACAATACTATGAGAAAAAATATGGAGGCAGATCAATAAGAAAAGAT CCCTTTTTCAGAAACCTTTCAACGAAGTCTAAAAATAGGAAGCTTCCAGAACCACCAGAC AATGAGGATGAAGATGAAGATGTCAAAGCTGAAAGACTAAAGGTCAAAGAGCTGATGGGT TGCCAGTGTTGTGAGGAGAAACCATCCATTATGGTCAGCAATTTGCATAAAGAATATGAT GACAAGAAAGATTTTCTTCTTTCAAGAAAAGTAAAGAAAGTGGCAACTAAATACATCTCT TTCTGTGTGAAAAAAGGAGAGATCTTAGGACTATTGGGTCCAAATGGTGCTGGCAAAAGC ACAATTATTAATATTCTGGTTGGTGATATTGAACCAACTTCAGGCCAGGTATTTTTAGGA GATTATTCTTCAGAGACAAGTGAAGATGATGATTCACTGAAGTGTATGGGTTACTGTCCT CAGATAAACCCTTTGTGGCCAGATACTACATTGCAGGAACATTTTGAAATTTATGGAGCT GTCAAAGGAATGAGTGCAAGTGACATGAAAGAAGTCATAAGTCGAATAACACATGCACTT GATTTAAAAGAACATCTTCAGAAGACTGTAAAGAAACTACCTGCAGGAATCAAACGAAAG TTGTGTTTTGCTCTAAGTATGCTAGGGAATCCTCAGATTACTTTGCTAGATGAACCATCT ACAGGTATGGATCCCAAAGCCAAACAGCACATGTGGCGAGCAATTCGAACTGCATTTAAA AACAGAAAGCGGGCTGCTATTCTGACCACTCACTATATGGAGGAGGCAGAGGCTGTCTGT GATCGAGTAGCTATCATGGTGTCTGGGCAGTTAAGATGTATCGGAACAGTACAACATCTA AAGAGTAAATTTGGAAAAGGCTACTTTTTGGAAATTAAATTGAAGGACTGGATAGAAAAC CTAGAAGTAGACCGCCTTCAAAGAGAAATTCAGTATATTTTCCCAAATGCAAGCCGTCAG GAAAGTTTTTCTTCTATTTTGGCTTATAAAATTCCTAAGGAAGATGTTCAGTCCCTTTCA CAATCTTTTTTTAAGCTGGAAGAAGCTAAACATGCTTTTGCCATTGAAGAATATAGCTTT TCTCAAGCAACATTGGAACAGGTTTTTGTAGAACTCACTAAAGAACAAGAGGAGGAAGAT AATAGTTGTGGAACTTTAAACAGCACACTTTGGTGGGAACGAACACAAGAAGATAGAGTA GTATTTTGA
- Chromosome Location
- 17
- Locus
- 17q24.3
- External Identifiers
Resource Link UniProtKB ID Q8WWZ7 UniProtKB Entry Name ABCA5_HUMAN GenBank Protein ID 17223620 GenBank Gene ID AY028897 HGNC ID HGNC:35 - General References
- Petry F, Kotthaus A, Hirsch-Ernst KI: Cloning of human and rat ABCA5/Abca5 and detection of a human splice variant. Biochem Biophys Res Commun. 2003 Jan 10;300(2):343-50. [Article]
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