Squalene monooxygenase

Details

Name
Squalene monooxygenase
Synonyms
  • 1.14.14.17
  • SE
  • Squalene epoxidase
Gene Name
ERG1
Organism
Yeast
Amino acid sequence
>lcl|BSEQ0017505|Squalene monooxygenase
MSSVKYDAIIIGAGVIGPTIATAFARQGRKVLIVERDWSKPDRIVGELMQPAGIKALREL
GMIKAINNIRAVDCTGYYIKYYDETITIPYPLKKDACITNPVKPVPDAVDGVNDKLDSDS
TLNVDDWDFDERVRGAAFHHGDFLMNLRQICRDEPNVTAVEATVTKILRDPSDPNTVIGV
QTKQPSGTVDYHAKLTISCDGIYSKFRKELSPTNVPTIGSYFIGLYLKNAELPAKGKGHV
LLGGHAPALIYSVSPTETRVLCVYVSSKPPSAANDAVYKYLRDNILPAIPKETVPAFKEA
LEERKFRIMPNQYLSAMKQGSENHKGFILLGDSLNMRHPLTGGGMTVGLNDSVLLAKLLH
PKFVEDFDDHQLIAKRLKTFHRKRKNLDAVINTLSISLYSLFAADKKPLRILRNGCFKYF
QRGGECVNGPIGLLSGMLPFPMLLFNHFFSVAFYSVYLNFIERGLLGFPLALFEAFEVLF
TAIVIFTPYLWNEIVR
Number of residues
496
Molecular Weight
55297.635
Theoretical pI
Not Available
GO Classification
Functions
flavin adenine dinucleotide binding / squalene monooxygenase activity
Processes
cell growth mode switching, budding to filamentous / cellular response to drug / cellular response to starvation / ergosterol biosynthetic process / filamentous growth / filamentous growth of a population of unicellular organisms in response to biotic stimulus / filamentous growth of a population of unicellular organisms in response to chemical stimulus / filamentous growth of a population of unicellular organisms in response to starvation / localization within membrane
Components
endoplasmic reticulum membrane / integral component of membrane / plasma membrane
General Function
Squalene monooxygenase activity
Specific Function
Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
Pfam Domain Function
Transmembrane Regions
4-24 431-451 466-486
Cellular Location
Microsome membrane
Gene sequence
>lcl|BSEQ0017506|Squalene monooxygenase (ERG1)
ATGAGTTCAGTTAAGTATGATGCTATTATTATTGGTGCAGGGGTTATTGGTCCCACCATT
GCAACTGCTTTTGCCAGACAAGGGAGAAAGGTTTTGATTGTGGAAAGAGACTGGTCCAAG
CCAGATAGAATTGTTGGAGAGTTGATGCAACCGGCTGGTATCAAGGCATTAAGAGAGTTG
GGGATGATCAAAGCTATTAATAATATTAGGGCTGTTGATTGTACTGGGTACTATATCAAA
TATTATGACGAGACCATTACTATCCCTTATCCATTGAAAAAAGATGCCTGTATCACTAAT
CCAGTGAAGCCAGTTCCTGATGCCGTTGATGGTGTAAATGATAAATTGGATAGTGATTCC
ACATTGAATGTTGATGACTGGGATTTTGATGAAAGAGTACGTGGGGCTGCATTTCACCAT
GGGGATTTCCTTATGAATTTAAGACAAATTTGTCGTGATGAACCAAATGTTACCGCAGTT
GAAGCAACAGTAACAAAGATTTTGCGTGATCCTCTGGATCCTAACACAGTTATTGGTGTG
CAAACAAAACAACCCAGTGGCACTGTTGATTACCATGCAAAGTTGACAATCAGTTGTGAT
GGTATTTACTCCAAATTCAGAAAGGAATTAAGTCCTACTAATGTTCCAACCATTGGCTCT
TACTTTATTGGGTTGTATTTGAAGAATGCTGAATTACCAGCTAAGGGCAAAGGTCATGTG
TTATTGGGAGGACATGCACCAGCATTGATATATTCAGTGTCCCCAACTGAAACACGTGTA
TTGTGTGTTTATGTTTCATCAAAACCTCCTTCTGCTGCTAACGATGCAGTTTACAAGTAT
TTGAGAGATAACATTTTGCCAGCAATTCCTAAAGAGACTGTTCCTGCTTTTAAGGAAGCC
CTTGAAGAAAGAAAGTTTAGAATCATGCCAAACCAGTATCTTTCTGCTATGAAACAAGGT
AGTGAAAACCATAAAGGGTTTATATTGTTAGGTGATTCTTTAAATATGAGACATCCATTA
ACTGGGGGTGGTATGACAGTTGGTTTAAATGATAGTGTGTTATTAGCAAAATTGTTGCAT
CCAAAATTTGTTGAAGATTTTGATGATCACCAATTGATTGCTAAAAGATTAAAGACATTC
CACAGAAAAAGAAAGAATTTGGACGCTGTTATCAACACATTATCTATTTCATTATATTCA
TTATTTGCCGCTGATAAGAAACCTTTAAGAATATTAAGAAATGGTTGTTTTAAATATTTC
CAAAGAGGTGGAGAATGTGTTAACGGGCCAATTGGATTATTGAGTGGCATGTTACCATTC
CCAATGTTGTTATTCAACCATTTTTTCAGTGTTGCCTTCTATTCGGTCTATTTGAATTTT
ATAGAAAGAGGACTTTTGGGATTCCCATTGGCATTATTTGAGGCATTTGAAGTGTTGTTC
ACTGCAATTGTAATCTTTACTCCATATTTATGGAACGAGATTGTAAGATAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ92206
UniProtKB Entry NameERG1_CANAL
General References
  1. Favre B, Ryder NS: Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans. Gene. 1997 Apr 11;189(1):119-26. [Article]
  2. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S: The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. Epub 2004 May 3. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00525Tolnaftateapproved, investigational, vet_approvedyesinhibitorDetails
DB00857Terbinafineapproved, investigational, vet_approvedyesinhibitorDetails