Atypical kinase COQ8B, mitochondrial
Details
- Name
- Atypical kinase COQ8B, mitochondrial
- Synonyms
- 2.7.-.-
- AarF domain-containing protein kinase 4
- ADCK4
- Coenzyme Q protein 8B
- Gene Name
- COQ8B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051698|Atypical kinase COQ8B, mitochondrial MWLKVGGLLRGTGGQLGQTVGWPCGALGPGPHRWGPCGGSWAQKFYQDGPGRGLGEEDIR RAREARPRKTPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAEMAKKSMPGGRL QSEGGSGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFISPQLQHIFERVR QSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQY PGIAQSIQSDVQNLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQL LANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFE FRFMQTDPNWANFLYDASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKS RDLKFLTGFETKAFSDAHVEAVMILGEPFATQGPYDFGSGETARRIQDLIPVLLRHRLCP PPEETYALHRKLAGAFLACAHLRAHIACRDLFQDTYHRYWASRQPDAATAGSLPTKGDSW VDPS
- Number of residues
- 544
- Molecular Weight
- 60068.925
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / kinase activityProcessescerebellar Purkinje cell layer morphogenesis / ubiquinone biosynthetic processComponentscytosol / integral component of membrane / mitochondrial membrane / mitochondrion / plasma membrane
- General Function
- Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration (PubMed:24270420).
- Specific Function
- Atp binding
- Pfam Domain Function
- ABC1 (PF03109)
- Transmembrane Regions
- 92-108
- Cellular Location
- Mitochondrion membrane
- Gene sequence
>lcl|BSEQ0051699|Atypical kinase COQ8B, mitochondrial (COQ8B) ATGTGGCTGAAGGTGGGGGGCCTACTTCGGGGGACCGGTGGACAGCTGGGCCAGACTGTT GGTTGGCCTTGTGGGGCCCTGGGGCCTGGGCCCCACCGCTGGGGACCATGTGGAGGTTCT TGGGCCCAAAAGTTTTACCAGGATGGGCCTGGGAGAGGCCTGGGTGAGGAGGACATTCGC AGGGCACGGGAGGCCCGTCCCAGGAAGACACCCCGGCCCCAGCTGAGTGACCGCTCTCGA GAACGCAAGGTGCCTGCCTCCCGCATCAGCCGCTTGGCCAACTTTGGGGGACTGGCTGTG GGCTTGGGGCTAGGAGTACTGGCCGAGATGGCTAAGAAGTCCATGCCAGGAGGTCGTCTG CAGTCAGAGGGTGGTTCTGGGCTGGACTCCAGCCCCTTCCTGTCGGAGGCCAATGCCGAG CGGATTGTGCAGACCTTATGTACAGTTCGAGGGGCCGCCCTCAAGGTTGGCCAGATGCTC AGCATCCAGGACAACAGCTTCATCAGCCCTCAGCTGCAGCACATCTTTGAGCGGGTCCGC CAGAGCGCCGACTTCATGCCCCGCTGGCAGATGCTGAGAGTTCTTGAAGAGGAGCTCGGC AGGGACTGGCAGGCCAAGGTGGCCTCCTTGGAGGAGGTGCCCTTTGCCGCTGCCTCAATT GGGCAGGTGCACCAGGGCCTGCTGAGGGACGGGACGGAGGTGGCCGTGAAGATCCAGTAC CCCGGCATAGCCCAGAGCATTCAGAGCGATGTCCAGAACCTGCTGGCGGTACTCAAGATG AGCGCGGCCCTGCCCGCGGGCCTGTTTGCCGAGCAGAGCCTGCAGGCCTTGCAGCAGGAG CTGGCTTGGGAGTGTGACTACCGTCGTGAGGCGGCTTGTGCCCAGAATTTCAGGCAGCTG CTGGCAAATGACCCCTTCTTCCGGGTCCCAGCCGTGGTTAAGGAGCTGTGCACGACACGG GTGCTGGGCATGGAGCTGGCTGGAGGGGTCCCCCTGGACCAGTGCCAGGGCCTAAGCCAG GACCTGCGGAACCAGATTTGCTTCCAGCTCCTGACGCTGTGTCTGCGGGAGCTGTTTGAG TTCCGATTCATGCAGACTGACCCCAACTGGGCCAACTTCCTGTATGATGCCTCCAGCCAC CAGGTGACCCTGCTGGACTTTGGTGCAAGCCGGGAGTTTGGGACAGAGTTCACAGACCAT TACATCGAGGTGGTGAAGGCTGCAGCTGATGGAGACAGAGACTGTGTCCTGCAGAAGTCC AGGGACCTCAAATTCCTCACAGGCTTTGAAACCAAGGCATTCTCCGACGCCCACGTGGAG GCAGTGATGATCCTGGGGGAGCCTTTCGCCACCCAGGGCCCTTATGACTTTGGGTCGGGG GAAACGGCCCGCCGCATACAGGACCTCATCCCGGTGCTGCTGCGGCACCGGCTGTGTCCC CCACCCGAGGAGACCTATGCCCTGCACCGCAAGCTGGCAGGGGCTTTCCTGGCCTGTGCC CACCTCCGAGCCCACATCGCCTGCAGGGACCTCTTCCAGGACACCTACCACCGCTACTGG GCCAGTCGCCAGCCAGACGCAGCCACTGCCGGCAGCCTCCCCACCAAAGGGGACTCCTGG GTGGATCCCTCATGA
- Chromosome Location
- 19
- Locus
- 19q13.2
- External Identifiers
Resource Link UniProtKB ID Q96D53 UniProtKB Entry Name COQ8B_HUMAN HGNC ID HGNC:19041 - General References
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