ATP-sensitive inward rectifier potassium channel 15
Details
- Name
- ATP-sensitive inward rectifier potassium channel 15
- Synonyms
- Inward rectifier K(+) channel Kir1.3
- Inward rectifier K(+) channel Kir4.2
- KCNJ14
- Potassium channel, inwardly rectifying subfamily J member 15
- Gene Name
- KCNJ15
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013351|ATP-sensitive inward rectifier potassium channel 15 MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVID MKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLF SLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKF SHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVD SSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSY IPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQLEEKYRQEDQ RERELRTLLLQQSNV
- Number of residues
- 375
- Molecular Weight
- 42577.01
- Theoretical pI
- Not Available
- GO Classification
- FunctionsG-protein activated inward rectifier potassium channel activity / inward rectifier potassium channel activityProcessespotassium ion import / potassium ion transport / regulation of ion transmembrane transportComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
- Specific Function
- G-protein activated inward rectifier potassium channel activity
- Pfam Domain Function
- IRK (PF01007)
- Transmembrane Regions
- 64-88 142-163
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0013352|ATP-sensitive inward rectifier potassium channel 15 (KCNJ15) ATGGATGCCATTCACATCGGCATGTCCAGCACCCCCCTGGTGAAGCACACTGCTGGGGCT GGGCTCAAGGCCAACAGACCCCGCGTCATGTCCAAGAGTGGGCACAGCAACGTGAGAATT GACAAAGTGGATGGCATATACCTACTCTACCTGCAAGACCTGTGGACCACAGTTATCGAC ATGAAGTGGAGATACAAACTCACCCTGTTCGCTGCCACTTTTGTGATGACCTGGTTCCTT TTTGGAGTCATCTACTATGCCATCGCGTTTATTCATGGGGACTTAGAACCCGGTGAGCCC ATTTCAAATCATACCCCCTGCATCATGAAAGTGGACTCTCTCACTGGGGCGTTTCTCTTT TCCCTGGAATCCCAGACAACCATTGGCTATGGAGTCCGTTCCATCACAGAGGAATGTCCT CATGCCATCTTCCTGTTGGTTGCTCAGTTGGTCATCACGACCTTGATTGAGATCTTCATC ACCGGAACCTTCCTGGCCAAAATCGCCAGACCCAAAAAGCGGGCTGAGACCATCAAGTTC AGCCACTGTGCAGTCATCACCAAGCAGAATGGGAAGCTGTGCTTGGTGATTCAGGTAGCC AATATGAGGAAGAGCCTCTTGATTCAGTGCCAGCTCTCTGGCAAGCTCCTGCAGACCCAC GTCACCAAGGAGGGGGAGCGGATTCTCCTCAACCAAGCCACTGTCAAATTCCACGTGGAC TCCTCCTCTGAGAGCCCCTTCCTCATTCTGCCCATGACATTCTACCATGTGCTGGATGAG ACGAGCCCCCTGAGAGACCTCACACCCCAAAACCTAAAGGAGAAGGAGTTTGAGCTTGTG GTCCTCCTCAATGCCACTGTGGAATCCACCAGCGCTGTCTGCCAGAGCCGAACATCTTAT ATCCCAGAGGAAATCTACTGGGGTTTTGAGTTTGTGCCTGTGGTATCTCTCTCCAAAAAT GGAAAATATGTGGCTGATTTCAGTCAGTTTGAACAGATTCGGAAAAGCCCAGATTGCACA TTTTACTGTGCAGATTCTGAGAAACAGCAACTCGAGGAGAAGTACAGGCAGGAGGATCAG AGGGAAAGAGAACTGAGGACACTTTTATTACAACAGAGCAATGTCTGA
- Chromosome Location
- 21
- Locus
- 21q22.13-q22.2
- External Identifiers
Resource Link UniProtKB ID Q99712 UniProtKB Entry Name KCJ15_HUMAN HGNC ID HGNC:6261 - General References
- Gosset P, Ghezala GA, Korn B, Yaspo ML, Poutska A, Lehrach H, Sinet PM, Creau N: A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). Genomics. 1997 Sep 1;44(2):237-41. [Article]
- Shuck ME, Piser TM, Bock JH, Slightom JL, Lee KS, Bienkowski MJ: Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). J Biol Chem. 1997 Jan 3;272(1):586-93. [Article]
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- Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ: CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Mol Cell Neurosci. 1998 Jun;11(3):161-72. [Article]
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