Equilibrative nucleoside transporter 1
Details
- Name
- Equilibrative nucleoside transporter 1
- Synonyms
- ENT1
- Equilibrative NBMPR-sensitive nucleoside transporter
- Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter
- Nucleoside transporter, es-type
- Solute carrier family 29 member 1
- Gene Name
- SLC29A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002395|Equilibrative nucleoside transporter 1 MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
- Number of residues
- 456
- Molecular Weight
- 50218.805
- Theoretical pI
- 8.39
- GO Classification
- Functionsnucleoside transmembrane transporter activityProcessescellular response to glucose stimulus / cellular response to hypoxia / excitatory postsynaptic potential / lactation / nucleobase-containing compound metabolic process / nucleoside transmembrane transport / nucleoside transport / sleep / transmembrane transport / uridine transportComponentsapical plasma membrane / basolateral plasma membrane / integral component of plasma membrane / membrane / plasma membrane
- General Function
- Nucleoside transmembrane transporter activity
- Specific Function
- Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
- Pfam Domain Function
- Nucleoside_tran (PF01733)
- Transmembrane Regions
- 13-29 83-107 112-130 139-157 175-199 207-227 292-311 324-342 360-378 394-413 432-452
- Cellular Location
- Basolateral cell membrane
- Gene sequence
>lcl|BSEQ0019080|Equilibrative nucleoside transporter 1 (SLC29A1) ATGACAACCAGTCACCAGCCTCAGGACAGATACAAAGCTGTCTGGCTTATCTTCTTCATG CTGGGTCTGGGAACGCTGCTCCCGTGGAATTTTTTCATGACGGCCACTCAGTATTTCACA AACCGCCTGGACATGTCCCAGAATGTGTCCTTGGTCACTGCTGAACTGAGCAAGGACGCC CAGGCGTCAGCCGCCCCTGCAGCACCCTTGCCTGAGCGGAACTCTCTCAGTGCCATCTTC AACAATGTCATGACCCTATGTGCCATGCTGCCCCTGCTGTTATTCACCTACCTCAACTCC TTCCTGCATCAGAGGATCCCCCAGTCCGTACGGATCCTGGGCAGCCTGGTGGCCATCCTG CTGGTGTTTCTGATCACTGCCATCCTGGTGAAGGTGCAGCTGGATGCTCTGCCCTTCTTT GTCATCACCATGATCAAGATCGTGCTCATTAATTCATTTGGTGCCATCCTGCAGGGCAGC CTGTTTGGTCTGGCTGGCCTTCTGCCTGCCAGCTACACGGCCCCCATCATGAGTGGCCAG GGCCTAGCAGGCTTCTTTGCCTCCGTGGCCATGATCTGCGCTATTGCCAGTGGCTCGGAG CTATCAGAAAGTGCCTTCGGCTACTTTATCACAGCCTGTGCTGTTATCATTTTGACCATC ATCTGTTACCTGGGCCTGCCCCGCCTGGAATTCTACCGCTACTACCAGCAGCTCAAGCTT GAAGGACCCGGGGAGCAGGAGACCAAGTTGGACCTCATTAGCAAAGGAGAGGAGCCAAGA GCAGGCAAAGAGGAATCTGGAGTTTCAGTCTCCAACTCTCAGCCCACCAATGAAAGCCAC TCTATCAAAGCCATCCTGAAAAATATCTCAGTCCTGGCTTTCTCTGTCTGCTTCATCTTC ACTATCACCATTGGGATGTTTCCAGCCGTGACTGTTGAGGTCAAGTCCAGCATCGCAGGC AGCAGCACCTGGGAACGTTACTTCATTCCTGTGTCCTGTTTCTTGACTTTCAATATCTTT GACTGGTTGGGCCGGAGCCTCACAGCTGTATTCATGTGGCCTGGGAAGGACAGCCGCTGG CTGCCAAGCCTGGTGCTGGCCCGGCTGGTGTTTGTGCCACTGCTGCTGCTGTGCAACATT AAGCCCCGCCGCTACCTGACTGTGGTCTTCGAGCACGATGCCTGGTTCATCTTCTTCATG GCTGCCTTTGCCTTCTCCAACGGCTACCTCGCCAGCCTCTGCATGTGCTTCGGGCCCAAG AAAGTGAAGCCAGCTGAGGCAGAGACCGCAGGAGCCATCATGGCCTTCTTCCTGTGTCTG GGTCTGGCACTGGGGGCTGTTTTCTCCTTCCTGTTCCGGGCAATTGTGTGA
- Chromosome Location
- 6
- Locus
- 6p21.2-p21.1
- External Identifiers
Resource Link UniProtKB ID Q99808 UniProtKB Entry Name S29A1_HUMAN GenBank Protein ID 1845345 GenBank Gene ID U81375 GenAtlas ID SLC29A1 HGNC ID HGNC:11003 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00197 Troglitazone approved, investigational, withdrawn no inhibitor Details DB00987 Cytarabine approved, investigational unknown substrate Details DB01073 Fludarabine approved unknown substrate Details DB00441 Gemcitabine approved no substrate Details DB00811 Ribavirin approved unknown substrate Details DB00642 Pemetrexed approved, investigational no inducer Details DB02745 Uridine experimental, investigational unknown Details DB00943 Zalcitabine approved, investigational unknown Details DB00900 Didanosine approved unknown Details DB00544 Fluorouracil approved unknown substrate Details DB01033 Mercaptopurine approved unknown substrate Details DB00898 Ethanol approved unknown Details DB09061 Cannabidiol approved, investigational unknown inhibitor Details DB09327 Tegafur-uracil approved, investigational no substrate Details DB14011 Nabiximols investigational unknown inhibitor Details DB14009 Medical Cannabis experimental, investigational unknown inhibitor Details DB12010 Fostamatinib approved, investigational unknown inhibitor Details DB00432 Trifluridine approved, investigational unknown substrate Details DB00640 Adenosine approved, investigational unknown substrate Details DB01280 Nelarabine approved, investigational no substrate Details