Serine/threonine-protein kinase 33
Details
- Name
- Serine/threonine-protein kinase 33
- Synonyms
- 2.7.11.1
- Gene Name
- STK33
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051650|Serine/threonine-protein kinase 33 MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERK KEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGR ILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQ VFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLK LENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDY SQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQ LMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPS TEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAE IKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
- Number of residues
- 514
- Molecular Weight
- 57830.355
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / protein serine/threonine kinase activityProcessesintracellular signal transduction / peptidyl-serine phosphorylation / peptidyl-threonine phosphorylation / protein autophosphorylationComponentsintracellular / perinuclear region of cytoplasm
- General Function
- Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.
- Specific Function
- Atp binding
- Pfam Domain Function
- Pkinase (PF00069)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051651|Serine/threonine-protein kinase 33 (STK33) ATGGCTGATAGTGGCTTAGATAAAAAATCCACAAAATGCCCCGACTGTTCATCTGCTTCT CAGAAAGATGTACTTTGTGTATGTTCCAGCAAAACAAGGGTTCCTCCAGTTTTGGTGGTG GAAATGTCACAGACATCAAGCATTGGTAGTGCAGAATCTTTAATTTCACTGGAGAGAAAA AAAGAAAAAAATATCAACAGAGATATAACCTCCAGGAAAGATTTGCCCTCAAGAACCTCA AATGTAGAGAGAAAAGCATCTCAGCAACAATGGGGTCGGGGCAACTTTACAGAAGGAAAA GTTCCTCACATAAGGATTGAGAATGGAGCTGCTATTGAGGAAATCTATACCTTTGGAAGA ATATTGGGAAAAGGGAGCTTTGGAATAGTCATTGAAGCGACAGACAAGGAAACAGAAACG AAGTGGGCAATTAAAAAAGTGAACAAAGAAAAGGCTGGAAGCTCTGCTGTGAAGTTACTT GAACGAGAGGTGAACATTCTGAAAAGTGTAAAACATGAACACATCATACATCTGGAACAA GTATTTGAAACGCCAAAGAAAATGTACCTTGTGATGGAGCTTTGTGAGGATGGAGAACTC AAAGAAATTCTGGATAGGAAAGGGCATTTCTCAGAGAATGAGACAAGGTGGATCATTCAA AGTCTCGCATCAGCTATAGCATATCTTCACAATAATGATATTGTACATAGAGATCTGAAA CTGGAAAATATAATGGTTAAAAGCAGTCTTATTGATGATAACAATGAAATAAACTTAAAC ATAAAGGTGACTGATTTTGGCTTAGCGGTGAAGAAGCAAAGTAGGAGTGAAGCCATGCTG CAGGCCACATGTGGGACTCCTATCTATATGGCCCCTGAAGTTATCAGTGCCCACGACTAT AGCCAGCAGTGTGACATTTGGAGCATAGGCGTCGTAATGTACATGTTATTACGTGGAGAA CCACCCTTTTTGGCAAGCTCAGAAGAGAAGCTTTTTGAGTTAATAAGAAAAGGAGAACTA CATTTTGAAAATGCAGTCTGGAATTCCATAAGTGACTGTGCTAAAAGTGTTTTGAAACAA CTTATGAAAGTAGATCCTGCTCACAGAATCACAGCTAAGGAACTACTAGATAACCAGTGG TTAACAGGCAATAAACTTTCTTCGGTGAGACCAACCAATGTATTAGAGATGATGAAGGAA TGGAAAAATAACCCAGAAAGTGTTGAGGAAAACACAACAGAAGAGAAGAATAAGCCGTCC ACTGAAGAAAAGTTGAAAAGTTACCAACCCTGGGGAAATGTCCCTGATGCCAATTACACT TCAGATGAAGAGGAGGAAAAACAGTCTACTGCTTATGAAAAGCAATTTCCTGCAACCAGT AAGGACAACTTTGATATGTGCAGTTCAAGTTTCACATCTAGCAAACTCCTTCCAGCTGAA ATCAAGGGAGAAATGGAGAAAACCCCTGTGACTCCAAGCCAAGGAACAGCAACCAAGTAC CCTGCTAAATCCGGCGCCCTGTCCAGAACCAAAAAGAAACTCTAA
- Chromosome Location
- 11
- Locus
- 11p15.4
- External Identifiers
Resource Link UniProtKB ID Q9BYT3 UniProtKB Entry Name STK33_HUMAN HGNC ID HGNC:14568 - General References
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- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
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- Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [Article]
- Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [Article]
- Babij C, Zhang Y, Kurzeja RJ, Munzli A, Shehabeldin A, Fernando M, Quon K, Kassner PD, Ruefli-Brasse AA, Watson VJ, Fajardo F, Jackson A, Zondlo J, Sun Y, Ellison AR, Plewa CA, San MT, Robinson J, McCarter J, Schwandner R, Judd T, Carnahan J, Dussault I: STK33 kinase activity is nonessential in KRAS-dependent cancer cells. Cancer Res. 2011 Sep 1;71(17):5818-26. doi: 10.1158/0008-5472.CAN-11-0778. Epub 2011 Jul 8. [Article]
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