Nitric oxide reductase

Details

Name

Nitric oxide reductase

Synonyms

• 1.-.-.-
• Flavoprotein A
• FMN protein FprA
• Type A flavoprotein FprA

Gene Name

fprA

Organism

Moorella thermoacetica (strain ATCC 39073)

Amino acid sequence

>lcl|BSEQ0011834|Nitric oxide reductase
MSQPVAITDGIYWVGAVDWNIRYFHGPAFSTHRGTTYNAYLIVDDKTALVDTVYEPFKEE
LIAKLKQIKDPVKLDYLVVNHTESDHAGAFPAIMELCPDAHVLCTQRAFDSLKAHYSHID
FNYTIVKTGTSVSLGKRSLTFIEAPMLHWPDSMFTYVPEEALLLPNDAFGQHIATSVRFD
DQVDAGLIMDEAAKYYANILMPFSNLITKKLDEIQKINLAIKTIAPSHGIIWRKDPGRII
EAYARWAEGQGKAKAVIAYDTMWLSTEKMAHALMDGLVAGGCEVKLFKLSVSDRNDVIKE
ILDARAVLVGSPTINNDILPVVSPLLDDLVGLRPKNKVGLAFGAYGWGGGAQKILEERLK
AAKIELIAEPGPTVQWVPRGEDLQRCYELGRKIAARIAD

Number of residues

399

Molecular Weight

44296.64

Theoretical pI

6.29

GO Classification

Functions

electron carrier activity / FMN binding / metal ion binding / oxidoreductase activity

General Function

Oxidoreductase activity

Specific Function

Has nitric oxide reductase activity in combination with Hrb; probably involved in nitrosative stress protection.

Pfam Domain Function

• Flavodoxin_1 (PF00258)
• Lactamase_B (PF00753)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0011835|Nitric oxide reductase (fprA)
ATGAGCCAGCCTGTCGCCATTACCGACGGCATCTACTGGGTAGGGGCCGTTGACTGGAAC
ATCCGCTACTTCCACGGTCCCGCTTTTTCCACCCACCGCGGTACAACTTATAATGCCTAT
CTGATTGTCGACGATAAAACCGCCCTGGTGGATACTGTCTATGAACCCTTTAAAGAAGAA
CTCATTGCCAAACTAAAGCAAATAAAAGATCCGGTTAAACTCGACTACCTGGTGGTCAAC
CATACCGAAAGCGATCATGCCGGCGCCTTCCCGGCCATCATGGAACTCTGTCCAGACGCC
CACGTCCTCTGCACCCAGCGGGCCTTTGACAGCCTGAAAGCCCATTATAGCCACATCGAT
TTCAACTATACCATTGTCAAAACCGGGACCAGCGTCAGCCTGGGTAAACGCTCCCTGACC
TTCATCGAGGCGCCCATGCTCCACTGGCCCGACAGCATGTTTACCTATGTACCGGAAGAA
GCCCTGCTCCTTCCCAATGATGCCTTCGGCCAGCATATCGCCACCAGCGTCCGCTTCGAC
GACCAGGTGGATGCCGGCCTGATTATGGACGAGGCGGCCAAGTACTATGCCAATATTCTC
ATGCCCTTCAGCAACCTGATTACCAAAAAGCTGGATGAAATCCAGAAGATAAACCTGGCC
ATCAAAACCATAGCCCCCAGCCACGGCATTATCTGGCGTAAAGATCCCGGCCGAATCATC
GAAGCTTACGCCCGCTGGGCCGAGGGTCAGGGTAAGGCCAAAGCCGTCATCGCCTACGAC
ACCATGTGGCTGAGCACAGAAAAGATGGCCCACGCCCTGATGGACGGCCTGGTGGCCGGC
GGCTGCGAGGTCAAGCTCTTCAAGCTGTCCGTATCCGACCGCAACGATGTGATCAAAGAA
ATTCTGGACGCCCGAGCCGTCCTGGTCGGCTCGCCGACGATCAATAACGATATCCTGCCG
GTGGTCTCGCCGCTCCTGGACGACCTGGTAGGATTAAGGCCCAAGAATAAAGTTGGCCTG
GCCTTCGGCGCCTATGGCTGGGGCGGCGGCGCCCAAAAGATCCTGGAAGAACGCTTGAAG
GCAGCTAAAATCGAACTGATAGCCGAGCCCGGCCCCACCGTCCAATGGGTTCCCCGTGGC
GAGGACCTGCAGCGCTGCTACGAGCTGGGCCGGAAAATCGCAGCGCGCATAGCCGATTAA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q9FDN7
UniProtKB Entry Name	FPRA_MOOTA
GenBank Gene ID	AF202316

General References

1. Das A, Coulter ED, Kurtz DM Jr, Ljungdahl LG: Five-gene cluster in Clostridium thermoaceticum consisting of two divergent operons encoding rubredoxin oxidoreductase- rubredoxin and rubrerythrin-type A flavoprotein- high-molecular-weight rubredoxin. J Bacteriol. 2001 Mar;183(5):1560-7. [Article]
2. Pierce E, Xie G, Barabote RD, Saunders E, Han CS, Detter JC, Richardson P, Brettin TS, Das A, Ljungdahl LG, Ragsdale SW: The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum). Environ Microbiol. 2008 Oct;10(10):2550-73. doi: 10.1111/j.1462-2920.2008.01679.x. Epub 2008 Jun 9. [Article]
3. Silaghi-Dumitrescu R, Coulter ED, Das A, Ljungdahl LG, Jameson GN, Huynh BH, Kurtz DM Jr: A flavodiiron protein and high molecular weight rubredoxin from Moorella thermoacetica with nitric oxide reductase activity. Biochemistry. 2003 Mar 18;42(10):2806-15. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB03247	Flavin mononucleotide	approved, investigational	unknown		Details