IAG-nucleoside hydrolase
Details
- Name
- IAG-nucleoside hydrolase
- Synonyms
- Not Available
- Gene Name
- Not Available
- Organism
- Trypanosoma vivax
- Amino acid sequence
>lcl|BSEQ0022072|IAG-nucleoside hydrolase MAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNN MNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQL LADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTD GTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGT MWAMCTHCELLRDGDGYYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAE KYPLTFVARNPEAEFFLDMLLRSARAC
- Number of residues
- 327
- Molecular Weight
- 36330.44
- Theoretical pI
- 4.43
- GO Classification
- Functionshydrolase activity / metal ion binding
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Pfam Domain Function
- IU_nuc_hydro (PF01156)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0006408|984 bp ATGGCAAAGAATGTCGTGCTGGACCATGATGGAAATCTAGACGACTTTGTCGCTATGGTG TTGCTGGCTTCCAACACGGAGAAGGTACGACTTATTGGGGCACTCTGTACCGATGCGGAT TGCTTCGTTGAGAATGGTTTCAACGTCACTGGGAAGATAATGTGCCTGATGCACAACAAC ATGAATCTTCCATTGTTTCCTATCGGCAAATCAGCGGCGACCGCCGTCAATCCCTTCCCG AAAGAATGGCGGTGCCTGGCCAAGAACATGGATGATATGCCGATTCTCAACATACCAGAG AATGTGGAACTGTGGGATAAAATAAAGGCTGAGAATGAAAAGTACGAAGGACAGCAACTG CTTGCGGATTTGGTGATGAATTCGGAAGAAAAGGTTACGATTTGTGTCACTGGGCCACTC TCCAACGTTGCCTGGTGCATTGACAAGTACGGCGAGAAGTTCACATCAAAGGTGGAGGAA TGCGTCATCATGGGAGGTGCTGTTGATGTTCGTGGCAACGTGTTTCTCCCAAGCACTGAT GGTACGGCGGAGTGGAACATTTACTGGGACCCTGCGTCGGCTAAGACTGTCTTTGGTTGC CCAGGCCTTCGCCGCATCATGTTCTCGCTCGACTCAACAAACACTGTTCCGGTTAGGTCT CCCTACGTCCAACGCTTTGGCGAACAAACAAACTTTCTTCTTTCCATTCTTGTGGGTACA ATGTGGGCAATGTGCACACACTGTGAGTTATTGCGTGATGGGGATGGCTACTACGCCTGG GACGCACTCACTGCGGCCTACGTTGTCGACCAGAAGGTTGCTAATGTGGACCCTGTCCCT ATTGACGTGGTGGTGGACAAGCAGCCGAATGAAGGCGCGACAGTGCGGACCGACGCGGAG AAGTACCCACTCACATTTGTGGCGAGGAACCCCGAGGCCGAATTCTTTTTGGACATGCTC CTACGGAGTGCGCGTGCTTGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9GPQ4 UniProtKB Entry Name Q9GPQ4_TRYVI GenBank Gene ID AF311701 - General References
- Versees W, Decanniere K, Pelle R, Depoorter J, Brosens E, Parkin DW, Steyaert J: Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax. J Mol Biol. 2001 Apr 13;307(5):1363-79. [Article]
- Versees W, Decanniere K, Van Holsbeke E, Devroede N, Steyaert J: Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax. J Biol Chem. 2002 May 3;277(18):15938-46. Epub 2002 Feb 19. [Article]
- Versees W, Loverix S, Vandemeulebroucke A, Geerlings P, Steyaert J: Leaving group activation by aromatic stacking: an alternative to general acid catalysis. J Mol Biol. 2004 Apr 16;338(1):1-6. [Article]
- Versees W, Barlow J, Steyaert J: Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis. J Mol Biol. 2006 Jun 2;359(2):331-46. Epub 2006 Mar 29. [Article]
- Vandemeulebroucke A, De Vos S, Van Holsbeke E, Steyaert J, Versees W: A flexible loop as a functional element in the catalytic mechanism of nucleoside hydrolase from Trypanosoma vivax. J Biol Chem. 2008 Aug 8;283(32):22272-82. doi: 10.1074/jbc.M803705200. Epub 2008 Jun 2. [Article]
- Versees W, Goeminne A, Berg M, Vandemeulebroucke A, Haemers A, Augustyns K, Steyaert J: Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors. Biochim Biophys Acta. 2009 Jun;1794(6):953-60. doi: 10.1016/j.bbapap.2009.02.011. Epub 2009 Mar 10. [Article]