Acetylglutamate kinase

Details

Name
Acetylglutamate kinase
Synonyms
  • 2.7.2.8
  • AGK
  • N-acetyl-L-glutamate 5-phosphotransferase
  • NAG kinase
Gene Name
argB
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Amino acid sequence
>lcl|BSEQ0011405|Acetylglutamate kinase
MTLSRDDAAQVAKVLSEALPYIRRFVGKTLVIKYGGNAMESEELKAGFARDVVLMKAVGI
NPVVVHGGGPQIGDLLKRLSIESHFIDGMRVTDAATMDVVEMVLGGQVNKDIVNLINRHG
GSAIGLTGKDAELIRAKKLTVTRQTPEMTKPEIIDIGHVGEVTGVNVGLLNMLVKGDFIP
VIAPIGVGSNGESYNINADLVAGKVAEALKAEKLMLLTNIAGLMDKQGQVLTGLSTEQVN
ELIADGTIYGGMLPKIRCALEAVQGGVTSAHIIDGRVPNAVLLEIFTDSGVGTLISNRKR
H
Number of residues
301
Molecular Weight
31848.87
Theoretical pI
6.81
GO Classification
Functions
acetylglutamate kinase activity / ATP binding
Processes
arginine biosynthetic process / proline biosynthetic process
Components
cytoplasm
General Function
Atp binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011406|Acetylglutamate kinase (argB)
ATGACCCTGAGTCGCGATGACGCCGCCCAGGTTGCCAAGGTCCTTTCCGAGGCCCTGCCC
TACATCCGCCGCTTCGTCGGCAAGACGCTGGTGATCAAGTACGGCGGCAACGCCATGGAG
AGCGAGGAGCTGAAGGCCGGCTTCGCCCGCGACGTGGTGCTGATGAAAGCGGTCGGCATC
AACCCGGTGGTGGTGCATGGCGGCGGCCCGCAGATCGGAGACCTGCTCAAGCGCCTGTCG
ATCGAGAGCCACTTCATCGACGGCATGCGCGTCACCGACGCGGCGACCATGGACGTGGTG
GAGATGGTCCTCGGCGGCCAGGTGAACAAGGACATCGTCAACCTGATCAACCGCCACGGC
GGCAGCGCCATCGGCCTGACCGGCAAGGACGCCGAGCTGATCCGCGCGAAGAAGCTCACC
GTGACCCGCCAGACCCCGGAGATGACCAAGCCGGAGATCATCGACATCGGCCACGTGGGC
GAAGTCACCGGGGTCAACGTCGGGCTGCTGAACATGCTGGTCAAGGGCGACTTCATTCCG
GTGATCGCGCCGATCGGCGTGGGCAGCAACGGCGAGTCCTACAACATCAATGCCGACCTG
GTGGCCGGCAAGGTGGCGGAAGCGCTGAAGGCCGAGAAACTGATGCTGCTGACCAACATC
GCCGGCCTGATGGACAAGCAGGGCCAGGTGCTGACCGGGCTGTCCACCGAACAGGTCAAC
GAGCTGATCGCCGACGGCACCATCTACGGCGGCATGCTGCCGAAGATCCGCTGCGCCCTG
GAAGCGGTGCAGGGCGGCGTGACCAGCGCGCACATCATCGATGGCCGGGTACCGAATGCC
GTGCTGCTGGAAATCTTCACCGACAGCGGCGTCGGCACCCTGATCAGCAACCGCAAGCGT
CACTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9HTN2
UniProtKB Entry NameARGB_PSEAE
GenBank Protein ID9951641
GenBank Gene IDAE004091
General References
  1. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
  2. Fernandez-Murga ML, Ramon-Maiques S, Gil-Ortiz F, Fita I, Rubio V: Towards structural understanding of feedback control of arginine biosynthesis: cloning and expression of the gene for the arginine-inhibited N-acetyl-L-glutamate kinase from Pseudomonas aeruginosa, purification and crystallization of the recombinant enzyme and preliminary X-ray studies. Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1045-7. Epub 2002 May 29. [Article]
  3. Ramon-Maiques S, Fernandez-Murga ML, Gil-Ortiz F, Vagin A, Fita I, Rubio V: Structural bases of feed-back control of arginine biosynthesis, revealed by the structures of two hexameric N-acetylglutamate kinases, from Thermotoga maritima and Pseudomonas aeruginosa. J Mol Biol. 2006 Feb 24;356(3):695-713. Epub 2005 Dec 12. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04075N-Acetyl-L-GlutamateexperimentalunknownDetails