BMP-2-inducible protein kinase

Details

Name
BMP-2-inducible protein kinase
Synonyms
  • 2.7.11.1
  • BIKE
Gene Name
BMP2K
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051706|BMP-2-inducible protein kinase
MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG
GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS
DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD
LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG
KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP
DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT
IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE
ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ
QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY
QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV
ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSD
KNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKD
QRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPE
NLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSA
QLSSDVAVETPKQEFDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTK
APFSKKVNVQECHAVGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFD
EITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARR
HKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLS
WHPPHQGLSDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQ
SQQSQPVELDPFGAAPFPSKQ
Number of residues
1161
Molecular Weight
129170.91
Theoretical pI
Not Available
GO Classification
Functions
AP-2 adaptor complex binding / ATP binding / phosphatase regulator activity / protein serine/threonine kinase activity
Processes
positive regulation of Notch signaling pathway / protein phosphorylation / regulation of bone mineralization / regulation of clathrin-dependent endocytosis
Components
cytoplasm / nuclear speck
General Function
May be involved in osteoblast differentiation.
Specific Function
Ap-2 adaptor complex binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0051707|BMP-2-inducible protein kinase (BMP2K)
ATGAAGAAGTTCTCTCGGATGCCCAAGTCGGAGGGCGGCAGCGGCGGCGGAGCGGCGGGT
GGCGGGGCTGGCGGGGCCGGGGCCGGGGCCGGCTGCGGCTCCGGCGGCTCGTCCGTGGGG
GTCCGGGTGTTCGCGGTCGGCCGCCACCAGGTCACCCTGGAAGAGTCGCTGGCCGAAGGT
GGATTCTCCACAGTTTTCCTCGTGCGTACTCACGGTGGAATCCGATGTGCATTGAAGCGA
ATGTATGTCAATAACATGCCAGACCTCAATGTTTGTAAAAGGGAAATTACAATTATGAAA
GAGCTATCTGGTCACAAAAATATTGTGGGCTATTTGGACTGTGCTGTTAATTCAATTAGT
GATAATGTATGGGAAGTCCTTATCTTAATGGAATATTGTCGAGCTGGACAGGTAGTGAAT
CAAATGAATAAGAAGCTACAGACGGGTTTTACAGAACCAGAAGTGTTACAGATATTCTGT
GATACCTGTGAAGCTGTTGCAAGGTTGCATCAGTGTAAGACTCCAATAATTCACCGGGAT
CTGAAGGTAGAAAATATTTTGTTGAATGATGGTGGGAACTATGTACTTTGTGACTTTGGC
AGTGCCACTAATAAATTTCTTAATCCTCAAAAAGATGGAGTTAATGTAGTAGAAGAAGAA
ATTAAAAAGTATACAACTCTGTCATACAGAGCCCCTGAAATGATCAACCTTTATGGAGGG
AAACCCATCACCACCAAGGCTGATATCTGGGCACTGGGATGTCTACTCTATAAACTTTGT
TTCTTCACTCTTCCTTTTGGTGAGAGTCAGGTTGCTATCTGTGATGGCAACTTCACCATC
CCAGACAATTCTCGTTACTCCCGTAACATACATTGCTTAATAAGGTTCATGCTTGAACCA
GATCCGGAACATAGACCTGATATATTTCAAGTGTCATATTTTGCATTTAAATTTGCCAAA
AAGGATTGTCCAGTCTCCAACATCAATAATTCTTCTATTCCTTCAGCTCTTCCTGAACCG
ATGACTGCTAGTGAAGCAGCTGCTAGGAAAAGCCAAATAAAAGCCAGAATAACAGATACC
ATTGGACCAACAGAAACCTCAATTGCACCAAGACAAAGACCAAAGGCCAACTCTGCTACT
ACTGCCACTCCCAGTGTGCTGACCATTCAAAGTTCAGCAACACCTGTTAAAGTCCTTGCT
CCTGGTGAATTCGGTAACCATAGACCAAAAGGGGCACTAAGACCTGGAAATGGCCCTGAA
ATTTTATTGGGTCAGGGACCTCCTCAGCAGCCGCCACAGCAGCATAGAGTACTCCAGCAA
CTACAGCAGGGAGATTGGAGATTACAGCAACTCCATTTACAGCATCGTCATCCTCACCAG
CAGCAGCAGCAGCAGCAGCAGCAACAGCAACAGCAGCAGCAGCAACAGCAACAGCAGCAG
CAGCAGCAGCAGCAGCAGCACCACCACCACCACCACCACCACCTACTTCAAGATGCTTAT
ATGCAGCAGTATCAACATGCAACACAGCAGCAACAGATGCTTCAACAACAATTTTTAATG
CATTCGGTATATCAACCACAACCTTCTGCATCACAGTATCCTACAATGATGCCGCAGTAT
CAGCAGGCTTTCTTTCAACAGCAGATGCTAGCTCAACATCAGCCGTCTCAACAACAGGCA
TCACCTGAATATCTTACCTCCCCTCAAGAGTTCTCACCAGCCTTAGTTTCCTACACTTCA
TCACTTCCAGCTCAGGTTGGAACCATAATGGACTCCTCCTATAGTGCCAATAGGTCAGTT
GCTGATAAAGAGGCCATTGCAAATTTCACAAATCAGAAGAACATCAGCAATCCACCTGAT
ATGTCAGGGTGGAATCCTTTTGGAGAGGATAATTTCTCTAAGTTAACAGAAGAGGAACTA
TTGGACAGAGAATTTGACCTTCTAAGATCAAATAGGCTCGAGGAGAGAGCATCCTCAGAT
AAGAATGTAGACTCACTTTCTGCTCCACATAACCATCCTCCAGAAGATCCTTTTGGTTCT
GTTCCTTTCATTTCTCATTCAGGTTCTCCTGAAAAGAAAGCTGAACATTCATCTATAAAT
CAAGAAAATGGCACTGCAAACCCTATCAAGAACGGTAAAACAAGTCCAGCATCTAAAGAT
CAGCGGACTGGAAAGAAAACCTCAGTACAGGGTCAAGTGCAAAAGGGGAATGATGAATCT
GAAAGTGATTTTGAATCAGATCCCCCTTCTCCTAAGAGCAGTGAAGAGGAAGAGCAAGAT
GATGAAGAAGTTCTTCAGGGGGAACAAGGAGATTTTAATGATGATGATACTGAACCAGAA
AATCTGGGTCATAGGCCTCTCCTCATGGATTCTGAAGATGAGGAAGAAGAGGAGAAACAT
AGCTCTGATTCTGATTATGAGCAGGCTAAAGCAAAGTACAGTGACATGAGCTCTGTCTAC
AGAGACAGATCTGGCAGTGGACCAACCCAAGATCTTAATACAATACTCCTCACCTCAGCC
CAATTATCCTCTGATGTTGCAGTGGAGACTCCCAAACAGGAGTTTGATGTATTTGGCGCT
GTCCCCTTCTTTGCAGTGCGTGCTCAACAGCCCCAGCAAGAAAAGAATGAAAAGAACCTC
CCTCAACACAGGTTTCCTGCTGCAGGACTGGAGCAGGAGGAATTTGATGTATTCACAAAG
GCGCCTTTTAGCAAGAAGGTGAATGTACAAGAATGCCATGCAGTGGGGCCTGAGGCACAT
ACTATCCCTGGTTATCCCAAAAGTGTAGATGTATTTGGCTCCACTCCATTTCAGCCCTTC
CTCACATCAACAAGTAAAAGTGAAAGCAATGAGGACCTTTTTGGGCTTGTGCCCTTTGAT
GAAATAACGGGGAGCCAGCAGCAAAAAGTCAAACAGCGCAGCTTACAGAAACTGTCCTCT
CGCCAAAGGCGCACAAAGCAGGATATGTCCAAAAGTAATGGGAAGCGGCATCATGGCACG
CCAACTAGCACAAAGAAGACTTTGAAGCCTACCTATCGCACTCCAGAGAGGGCTCGCAGG
CACAAAAAAGTGGGCCGCCGAGACTCTCAAAGTAGCAATGAATTTTTAACCATCTCAGAC
TCCAAGGAGAACATTAGTGTTGCACTGACTGATGGGAAAGATAGGGGGAATGTCTTACAA
CCTGAGGAGAGCCTGTTGGACCCCTTCGGTGCCAAGCCCTTCCATTCTCCAGACCTGTCA
TGGCACCCTCCACATCAGGGCCTGAGCGACATCCGTGCTGATCACAATACTGTCCTGCCA
GGGCGGCCAAGACAAAATTCACTACATGGGTCATTCCATAGTGCAGATGTATTGAAAATG
GATGATTTTGGTGCCGTGCCCTTTACAGAACTTGTGGTGCAAAGCATCACTCCACATCAG
TCCCAACAGTCCCAACCAGTCGAATTAGACCCATTTGGTGCTGCTCCATTTCCTTCTAAA
CAGTAG
Chromosome Location
4
Locus
4q21.21
External Identifiers
ResourceLink
UniProtKB IDQ9NSY1
UniProtKB Entry NameBMP2K_HUMAN
HGNC IDHGNC:18041
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails