Tryptophan--tRNA ligase 2
Details
- Name
- Tryptophan--tRNA ligase 2
- Synonyms
- 6.1.1.2
- TrpRS 2
- TrpRS II
- trpSII
- Tryptophanyl-tRNA synthetase 2
- Tryptophanyl-tRNA synthetase II
- Gene Name
- trpS2
- Organism
- Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
- Amino acid sequence
>lcl|BSEQ0011311|Tryptophan--tRNA ligase 2 MPFVDLEVPTMTTPTPAATPARPRVLTGDRPTGALHLGHLAGSLQNRVRLQDEAELFVLL ADVQALTDHFDRPEQVRENVLAVALDYLAAGLDPQKTTCVVQSAVPELAELTVYFLNLVT VSHLRQNPTVKAEIAQKGYGERVPAGFFVYPVSQAADIAAFGATLVPVGDDQLPMLEQTR EIVRRFNALYAPVLAEPQAQLSRVPRLPGLDGQAKMSKSLGNAIALGDSADEVARKVMGM YTDPGHLRASDPGRVEGNPVFTFLDAFDPDPARVQALKDQYRAGGLGDVKVKKHLIDVLN GVLAPIRTRRAEYERDPDAVLRFVTEGTARGREVAAQTLGQVRRAMRLFGH
- Number of residues
- 351
- Molecular Weight
- 38179.35
- Theoretical pI
- 6.64
- GO Classification
- FunctionsATP binding / tryptophan-tRNA ligase activityProcessestryptophanyl-tRNA aminoacylationComponentscytoplasm
- General Function
- Tryptophan-trna ligase activity
- Specific Function
- Catalyzes the formation of 5'adenyl-Trp and tRNA(Trp) but with 5-fold less activity than TrpRS. Increases the solubility of the nitric oxide synthase oxygenase (nos), as well as its affinity for substrate L-arginine and its nitric-oxide synthase activity. The complex between trpS2 and nos catalyzes the regioselective nitration of tryptophan at the 4-position.
- Pfam Domain Function
- tRNA-synt_1b (PF00579)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011312|Tryptophan--tRNA ligase 2 (trpS2) ATGACCACCCCGACCCCTGCCGCTACACCTGCCCGCCCCCGCGTCCTGACCGGGGACCGG CCCACCGGGGCGCTGCACCTCGGGCACCTCGCCGGGTCGCTGCAAAACCGGGTGCGCTTG CAAGACGAGGCCGAGCTGTTCGTGCTGCTTGCCGACGTGCAGGCGCTCACCGACCACTTC GACCGGCCCGAGCAGGTGCGCGAGAACGTGCTGGCGGTGGCGCTCGATTACCTCGCCGCC GGGCTCGACCCGCAGAAGACGACCTGCGTGGTGCAGTCGGCGGTGCCCGAACTCGCCGAG CTGACGGTCTATTTCCTCAATCTGGTCACGGTGTCGCACCTGCGCCAGAACCCCACCGTC AAGGCCGAAATCGCGCAAAAGGGCTACGGCGAGCGGGTTCCTGCCGGGTTTTTCGTGTAT CCGGTGTCGCAGGCCGCCGACATCGCCGCGTTCGGGGCCACGCTGGTGCCGGTGGGCGAC GACCAGTTGCCGATGCTCGAACAGACCCGCGAAATCGTGCGGCGCTTCAATGCGCTGTAT GCCCCGGTGCTCGCCGAGCCGCAGGCGCAGCTCAGCCGGGTGCCGCGTCTGCCGGGGCTC GACGGGCAGGCCAAGATGAGCAAGTCGCTCGGCAACGCGATTGCGCTCGGCGACTCTGCC GACGAGGTGGCGCGCAAGGTCATGGGCATGTACACCGACCCTGGCCACCTGCGGGCAAGT GATCCCGGACGGGTGGAGGGCAATCCGGTCTTCACCTTCCTCGACGCCTTCGACCCCGAT CCGGCGCGGGTGCAGGCGTTGAAAGACCAGTACCGCGCGGGCGGCCTCGGTGACGTGAAG GTCAAAAAGCACCTGATTGACGTGCTCAACGGGGTGCTGGCTCCCATCCGCACGCGGCGC GCCGAGTATGAGCGCGACCCCGACGCCGTGCTCCGGTTCGTCACGGAGGGCACGGCGCGG GGCCGGGAGGTGGCGGCGCAGACGCTCGGGCAGGTGCGGCGGGCGATGCGGTTGTTTGGG CACTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9RVD6 UniProtKB Entry Name SYW2_DEIRA GenBank Protein ID 6458825 GenBank Gene ID AE000513 - General References
- White O, Eisen JA, Heidelberg JF, Hickey EK, Peterson JD, Dodson RJ, Haft DH, Gwinn ML, Nelson WC, Richardson DL, Moffat KS, Qin H, Jiang L, Pamphile W, Crosby M, Shen M, Vamathevan JJ, Lam P, McDonald L, Utterback T, Zalewski C, Makarova KS, Aravind L, Daly MJ, Minton KW, Fleischmann RD, Ketchum KA, Nelson KE, Salzberg S, Smith HO, Venter JC, Fraser CM: Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. Science. 1999 Nov 19;286(5444):1571-7. [Article]
- Buddha MR, Keery KM, Crane BR: An unusual tryptophanyl tRNA synthetase interacts with nitric oxide synthase in Deinococcus radiodurans. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15881-6. Epub 2004 Nov 1. [Article]
- Buddha MR, Tao T, Parry RJ, Crane BR: Regioselective nitration of tryptophan by a complex between bacterial nitric-oxide synthase and tryptophanyl-tRNA synthetase. J Biol Chem. 2004 Nov 26;279(48):49567-70. Epub 2004 Oct 5. [Article]