Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Details

Name
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Synonyms
  • Amino acid transporter ATB0+
  • Solute carrier family 6 member 14
Gene Name
SLC6A14
Organism
Humans
Amino acid sequence
>lcl|BSEQ0010294|Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE
Number of residues
642
Molecular Weight
72152.145
Theoretical pI
8.27
GO Classification
Functions
amino acid transmembrane transporter activity / neurotransmitter
Processes
amino acid transmembrane transport / amino acid transport / cellular amino acid metabolic process / ion transport / response to toxic substance / transmembrane transport / transport
Components
brush border membrane / extracellular exosome / integral component of membrane / integral component of plasma membrane / plasma membrane / vesicle
General Function
Neurotransmitter:sodium symporter activity
Specific Function
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner.
Pfam Domain Function
Transmembrane Regions
45-65 72-92 110-130 235-255 261-281 315-335 348-368 399-419 450-477 480-500 528-548 563-583
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0010295|Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14)
ATGGACAAGTTGAAATGCCCGAGTTTCTTCAAGTGCAGGGAGAAGGAGAAAGTGTCGGCT
TCATCAGAGAATTTCCATGTTGGTGAAAATGATGAGAATCAGGACCGTGGTAACTGGTCC
AAAAAATCGGATTATCTTCTATCTATGATTGGATACGCAGTGGGATTAGGAAATGTGTGG
AGATTTCCATATCTGACCTACAGCAATGGTGGAGGCGCCTTCTTGATACCTTATGCAATT
ATGTTAGCATTGGCTGGTTTACCTTTGTTCTTTCTGGAGTGTTCACTGGGACAATTTGCT
AGCTTAGGTCCAGTTTCAGTTTGGAGGATTCTTCCATTGTTTCAAGGTGTGGGAATTACA
ATGGTCCTGATCTCCATTTTTGTGACAATCTATTACAATGTCATAATTGCCTATAGTCTT
TACTACATGTTTGCTTCTTTTCAAAGTGAACTACCATGGAAAAATTGTTCTTCGTGGTCA
GATAAAAACTGTAGCAGATCACCAATAGTAACTCACTGTAATGTGAGTACAGTGAATAAA
GGAATACAAGAGATCATCCAAATGAATAAAAGCTGGGTAGACATCAACAATTTTACCTGC
ATCAACGGCAGTGAAATTTATCAGCCAGGGCAGCTTCCCAGTGAACAATATTGGAATAAA
GTGGCGCTCCAACGGTCAAGTGGAATGAATGAGACTGGAGTAATTGTTTGGTATTTAGCA
CTTTGTCTTCTTCTGGCTTGGCTCATAGTTGGAGCAGCACTATTTAAAGGAATCAAATCG
TCTGGCAAGGTGGTATATTTTACAGCTCTTTTCCCCTATGTGGTCCTACTCATCCTGTTA
GTACGAGGTGCAACTCTGGAGGGTGCTTCAAAAGGCATTTCATACTATATTGGAGCCCAG
TCAAATTTTACAAAACTTAAGGAAGCTGAGGTATGGAAAGATGCTGCCACTCAGATATTT
TACTCCCTTTCAGTGGCTTGGGGTGGCTTAGTTGCTCTATCATCTTACAATAAGTTCAAA
AACAACTGCTTCTCTGATGCCATTGTGGTTTGTTTGACAAACTGTCTCACTAGCGTGTTT
GCTGGATTTGCTATTTTTTCTATATTGGGACACATGGCCCATATATCTGGAAAGGAAGTT
TCTCAAGTTGTAAAATCAGGTTTTGATTTGGCATTCATTGCCTATCCAGAGGCTCTAGCC
CAACTCCCAGGTGGTCCATTTTGGTCCATATTATTTTTTTTCATGCTTTTAACTTTGGGT
CTCGATTCTCAGTTTGCTTCGATTGAAACGATCACAACAACAATTCAAGATTTATTTCCC
AAAGTGATGAAGAAAATGAGGGTTCCCATAACTTTGGGCTGCTGCTTGGTTTTGTTTCTC
CTTGGTCTCGTCTGTGTGACTCAGGCTGGAATTTACTGGGTTCATCTGATTGACCACTTC
TGTGCTGGATGGGGCATTTTAATTGCAGCTATACTGGAGCTAGTTGGAATCATCTGGATT
TATGGAGGGAACAGATTCATTGAGGATACAGAAATGATGATTGGAGCAAAGAGGTGGATA
TTCTGGCTATGGTGGAGAGCTTGCTGGTTTGTAATTACGCCTATCCTTTTGATTGCAATA
TTTATCTGGTCATTGGTGCAATTTCATAGACCTAATTATGGCGCAATTCCATACCCTGAC
TGGGGAGTTGCTTTAGGCTGGTGTATGATTGTTTTCTGCATTATTTGGATTCCAATTATG
GCTATCATAAAAATAATTCAGGCTAAAGGAAACATCTTTCAACGCCTTATAAGTTGCTGC
AGACCAGCTTCTAACTGGGGTCCATACCTGGAACAACATCGTGGGGAAAGATATAAAGAC
ATGGTAGATCCTAAAAAAGAGGCTGACCATGAAATACCTACTGTTAGTGGCAGCAGAAAA
CCGGAATGA
Chromosome Location
X
Locus
Xq23-q24
External Identifiers
ResourceLink
UniProtKB IDQ9UN76
UniProtKB Entry NameS6A14_HUMAN
GenBank Protein ID5732680
GenBank Gene IDAF151978
GenAtlas IDSLC6A14
HGNC IDHGNC:11047
General References
  1. Sloan JL, Mager S: Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+). J Biol Chem. 1999 Aug 20;274(34):23740-5. [Article]
  2. Ross MT, Grafham DV, Coffey AJ, Scherer S, McLay K, Muzny D, Platzer M, Howell GR, Burrows C, Bird CP, Frankish A, Lovell FL, Howe KL, Ashurst JL, Fulton RS, Sudbrak R, Wen G, Jones MC, Hurles ME, Andrews TD, Scott CE, Searle S, Ramser J, Whittaker A, Deadman R, Carter NP, Hunt SE, Chen R, Cree A, Gunaratne P, Havlak P, Hodgson A, Metzker ML, Richards S, Scott G, Steffen D, Sodergren E, Wheeler DA, Worley KC, Ainscough R, Ambrose KD, Ansari-Lari MA, Aradhya S, Ashwell RI, Babbage AK, Bagguley CL, Ballabio A, Banerjee R, Barker GE, Barlow KF, Barrett IP, Bates KN, Beare DM, Beasley H, Beasley O, Beck A, Bethel G, Blechschmidt K, Brady N, Bray-Allen S, Bridgeman AM, Brown AJ, Brown MJ, Bonnin D, Bruford EA, Buhay C, Burch P, Burford D, Burgess J, Burrill W, Burton J, Bye JM, Carder C, Carrel L, Chako J, Chapman JC, Chavez D, Chen E, Chen G, Chen Y, Chen Z, Chinault C, Ciccodicola A, Clark SY, Clarke G, Clee CM, Clegg S, Clerc-Blankenburg K, Clifford K, Cobley V, Cole CG, Conquer JS, Corby N, Connor RE, David R, Davies J, Davis C, Davis J, Delgado O, Deshazo D, Dhami P, Ding Y, Dinh H, Dodsworth S, Draper H, Dugan-Rocha S, Dunham A, Dunn M, Durbin KJ, Dutta I, Eades T, Ellwood M, Emery-Cohen A, Errington H, Evans KL, Faulkner L, Francis F, Frankland J, Fraser AE, Galgoczy P, Gilbert J, Gill R, Glockner G, Gregory SG, Gribble S, Griffiths C, Grocock R, Gu Y, Gwilliam R, Hamilton C, Hart EA, Hawes A, Heath PD, Heitmann K, Hennig S, Hernandez J, Hinzmann B, Ho S, Hoffs M, Howden PJ, Huckle EJ, Hume J, Hunt PJ, Hunt AR, Isherwood J, Jacob L, Johnson D, Jones S, de Jong PJ, Joseph SS, Keenan S, Kelly S, Kershaw JK, Khan Z, Kioschis P, Klages S, Knights AJ, Kosiura A, Kovar-Smith C, Laird GK, Langford C, Lawlor S, Leversha M, Lewis L, Liu W, Lloyd C, Lloyd DM, Loulseged H, Loveland JE, Lovell JD, Lozado R, Lu J, Lyne R, Ma J, Maheshwari M, Matthews LH, McDowall J, McLaren S, McMurray A, Meidl P, Meitinger T, Milne S, Miner G, Mistry SL, Morgan M, Morris S, Muller I, Mullikin JC, Nguyen N, Nordsiek G, Nyakatura G, O'Dell CN, Okwuonu G, Palmer S, Pandian R, Parker D, Parrish J, Pasternak S, Patel D, Pearce AV, Pearson DM, Pelan SE, Perez L, Porter KM, Ramsey Y, Reichwald K, Rhodes S, Ridler KA, Schlessinger D, Schueler MG, Sehra HK, Shaw-Smith C, Shen H, Sheridan EM, Shownkeen R, Skuce CD, Smith ML, Sotheran EC, Steingruber HE, Steward CA, Storey R, Swann RM, Swarbreck D, Tabor PE, Taudien S, Taylor T, Teague B, Thomas K, Thorpe A, Timms K, Tracey A, Trevanion S, Tromans AC, d'Urso M, Verduzco D, Villasana D, Waldron L, Wall M, Wang Q, Warren J, Warry GL, Wei X, West A, Whitehead SL, Whiteley MN, Wilkinson JE, Willey DL, Williams G, Williams L, Williamson A, Williamson H, Wilming L, Woodmansey RL, Wray PW, Yen J, Zhang J, Zhou J, Zoghbi H, Zorilla S, Buck D, Reinhardt R, Poustka A, Rosenthal A, Lehrach H, Meindl A, Minx PJ, Hillier LW, Willard HF, Wilson RK, Waterston RH, Rice CM, Vaudin M, Coulson A, Nelson DL, Weinstock G, Sulston JE, Durbin R, Hubbard T, Gibbs RA, Beck S, Rogers J, Bentley DR: The DNA sequence of the human X chromosome. Nature. 2005 Mar 17;434(7031):325-37. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Tiwari HK, Allison DB: Do allelic variants of SLC6A14 predispose to obesity? J Clin Invest. 2003 Dec;112(11):1633-6. [Article]
  5. Suviolahti E, Oksanen LJ, Ohman M, Cantor RM, Ridderstrale M, Tuomi T, Kaprio J, Rissanen A, Mustajoki P, Jousilahti P, Vartiainen E, Silander K, Kilpikari R, Salomaa V, Groop L, Kontula K, Peltonen L, Pajukanta P: The SLC6A14 gene shows evidence of association with obesity. J Clin Invest. 2003 Dec;112(11):1762-72. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00172ProlinenutraceuticalunknownDetails
DB03929D-Serineapproved, experimentalunknownDetails
DB00577Valaciclovirapproved, investigationalunknownDetails
DB01610Valganciclovirapproved, investigationalunknownDetails
DB00130L-Glutamineapproved, investigational, nutraceuticalunknownsubstrateDetails