Endothelial protein C receptor
Details
- Name
- Endothelial protein C receptor
- Synonyms
- Activated protein C receptor
- APC receptor
- Endothelial cell protein C receptor
- EPCR
- Gene Name
- PROCR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010810|Endothelial protein C receptor MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEG PDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCEL PPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELRE FLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC
- Number of residues
- 238
- Molecular Weight
- 26671.245
- Theoretical pI
- 7.2
- GO Classification
- Functionsreceptor activityProcessesblood coagulation / immune response / leukocyte migration / negative regulation of coagulationComponentscell surface / centrosome / extracellular exosome / extracellular region / focal adhesion / integral component of plasma membrane / plasma membrane
- General Function
- Receptor activity
- Specific Function
- Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
- Pfam Domain Function
- MHC_I_3 (PF16497)
- Transmembrane Regions
- 211-231
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0010811|Endothelial protein C receptor (PROCR) ATGTTGACAACATTGCTGCCGATACTGCTGCTGTCTGGCTGGGCCTTTTGTAGCCAAGAC GCCTCAGATGGCCTCCAAAGACTTCATATGCTCCAGATCTCCTACTTCCGCGACCCCTAT CACGTGTGGTACCAGGGCAACGCGTCGCTGGGGGGACACCTAACGCACGTGCTGGAAGGC CCAGACACCAACACCACGATCATTCAGCTGCAGCCCTTGCAGGAGCCCGAGAGCTGGGCG CGCACGCAGAGTGGCCTGCAGTCCTACCTGCTCCAGTTCCACGGCCTCGTGCGCCTGGTG CACCAGGAGCGGACCTTGGCCTTTCCTCTGACCATCCGCTGCTTCCTGGGCTGTGAGCTG CCTCCCGAGGGCTCTAGAGCCCATGTCTTCTTCGAAGTGGCTGTGAATGGGAGCTCCTTT GTGAGTTTCCGGCCGGAGAGAGCCTTGTGGCAGGCAGACACCCAGGTCACCTCCGGAGTG GTCACCTTCACCCTGCAGCAGCTCAATGCCTACAACCGCACTCGGTATGAACTGCGGGAA TTCCTGGAGGACACCTGTGTGCAGTATGTGCAGAAACATATTTCCGCGGAAAACACGAAA GGGAGCCAAACAAGCCGCTCCTACACTTCGCTGGTCCTGGGCGTCCTGGTGGGCAGTTTC ATCATTGCTGGTGTGGCTGTAGGCATCTTCCTGTGCACAGGTGGACGGCGATGTTAA
- Chromosome Location
- 20
- Locus
- 20q11.2
- External Identifiers
Resource Link UniProtKB ID Q9UNN8 UniProtKB Entry Name EPCR_HUMAN GenBank Protein ID 565268 GenBank Gene ID L35545 GenAtlas ID PROCR HGNC ID HGNC:9452 - General References
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