SH2B adapter protein 3
Details
- Name
- SH2B adapter protein 3
- Synonyms
- LNK
- Lymphocyte adapter protein
- Lymphocyte-specific adapter protein Lnk
- Signal transduction protein Lnk
- Gene Name
- SH2B3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0019620|SH2B adapter protein 3 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
- Number of residues
- 575
- Molecular Weight
- 63224.45
- Theoretical pI
- Not Available
- GO Classification
- Functionsphosphate ion binding / signal transducer activity / signaling adaptor activityProcessesblood coagulation / cell differentiation / embryonic hemopoiesis / intracellular signal transductionComponentscytosol
- General Function
- Signaling adaptor activity
- Specific Function
- Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019621|SH2B adapter protein 3 (SH2B3) ATGGGATTCCCGGTGCTGTGCCGTGGCTGGAGGAGGACCTGGCCTGGCTGTGCCAGTTGG CTGGGAGCCCCTCCACCCCAGAAGCCCTTGCTCTCACCTCTTCTTCTGAATCATCGTTCT TCGAAGAGTTCAAGGCCCAAGCTACAAGCAGCTTGCTCCAGCATCCAGGAGGTCCGGTGG TGCACACGGCTTGAGATGCCTGACAACCTTTACACCTTTGTGCTGAAGGTGAAGGACCGG ACAGACATCATCTTTGAGGTGGGAGACGAGCAGCAGCTGAATTCATGGATGGCTGAGCTC TCGGAGTGCACAGGCCGAGGGCTGGAGAGCACAGAAGCAGAGATGCATATTCCCTCAGCC CTAGAGCCTAGCACGTCCAGCTCCCCAAGGGGCAGCACAGATTCCCTTAACCAAGGTGCT TCTCCTGGGGGGCTGCTGGACCCGGCCTGCCAGAAGACGGACCATTTCCTGTCCTGCTAC CCCTGGTTCCACGGCCCCATCTCCAGAGTGAAAGCAGCTCAGCTGGTTCAGCTGCAGGGC CCTGATGCTCATGGAGTGTTCCTGGTGCGGCAGAGCGAGACGCGGCGTGGGGAATACGTG CTCACTTTCAACTTTCAGGGGATAGCCAAGCACCTGCGCCTGTCGCTGACAGAGCGGGGC CAGTGCCGTGTGCAGCACCTCCACTTTCCCTCGGTCGTGGACATGCTCCACCACTTCCAG CGCTCGCCCATCCCACTCGAGTGCGGCGCCGCCTGTGATGTCCGGCTCTCCAGCTACGTG GTAGTCGTCTCCCAACCACCAGGTTCCTGCAACACGGTCCTCTTCCCTTTCTCCCTTCCT CACTGGGATTCAGAGTCCCTTCCTCACTGGGGTTCAGAGTTGGGCCTTCCCCACCTTAGT TCTTCTGGCTGTCCCCGGGGGCTCAGCCCAGAGGGTCTCCCAGGGCGATCCTCACCCCCC GAGCAGATCTTCCACCTGGTGCCTTCGCCCGAAGAACTGGCCAACAGCCTGCAGCACCTG GAGCATGAGCCTGTGAATCGAGCCCGGGACTCGGACTACGAAATGGACTCATCCTCCCGG AGCCACCTGCGGGCCATAGACAATCAGTACACACCTCTCTGA
- Chromosome Location
- 12
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9UQQ2 UniProtKB Entry Name SH2B3_HUMAN HGNC ID HGNC:29605 - General References
- Li Y, He X, Schembri-King J, Jakes S, Hayashi J: Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation. J Immunol. 2000 May 15;164(10):5199-206. [Article]
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