Thymidylate synthase ThyX
Details
- Name
- Thymidylate synthase ThyX
- Synonyms
- 2.1.1.148
- thy1
- TS
- Gene Name
- thyX
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Amino acid sequence
>lcl|BSEQ0020528|Thymidylate synthase ThyX MKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMKHGHETPFEHI VFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTE KISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLRADSHAQ WEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKEVQV
- Number of residues
- 220
- Molecular Weight
- 26003.785
- Theoretical pI
- 8.38
- GO Classification
- Functionsflavin adenine dinucleotide binding / thymidylate synthase (FAD) activityProcessesdTMP biosynthetic process
- General Function
- Thymidylate synthase (fad) activity
- Specific Function
- Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate.
- Pfam Domain Function
- Thy1 (PF02511)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0020529|Thymidylate synthase ThyX (thyX) ATGAAGATCGATATCTTGGACAAAGGATTCGTTGAACTTGTGGATGTGATGGGAAACGAC CTCTCCGCTGTACGGGCTGCCCGCGTTTCTTTCGATATGGGTTTGAAAGACGAAGAAAGG GATAGACATCTCATCGAATATCTCATGAAACACGGTCACGAGACACCTTTCGAACATATT GTCTTCACTTTCCACGTGAAAGCCCCTATATTCGTGGCGAGGCAGTGGTTCAGACACAGG ATCGCTTCTTACAACGAACTGAGCGGCAGATACTCGAAGCTCTCCTACGAATTCTACATT CCCTCTCCCGAACGCCTGGAAGGGTACAAAACGACCATCCCTCCCGAACGGGTGACGGAG AAGATCTCAGAAATAGTCGATAAAGCGTATCGAACGTATCTGGAGTTGATAGAAAGCGGT GTTCCTCGAGAAGTGGCAAGGATAGTGCTCCCTTTGAATCTGTACACGAGGTTTTTCTGG ACTGTGAACGCAAGAAGTCTCATGAACTTTTTGAACCTGAGGGCAGATTCTCACGCTCAG TGGGAAATTCAACAGTACGCTCTGGCAATCGCGAGAATTTTCAAAGAGAAGTGTCCCTGG ACTTTTGAGGCATTTCTTAAGTATGCTTATAAAGGAGATATCCTGAAGGAGGTACAGGTA TGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9WYT0 UniProtKB Entry Name THYX_THEMA GenBank Protein ID 4980954 GenBank Gene ID AE000512 - General References
- Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
- Kuhn P, Lesley SA, Mathews II, Canaves JM, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Hodgson KO, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kovarik JM, Kreusch AT, McMullan D, McPhillips TM, Miller MA, Miller M, Morse A, Moy K, Ouyang J, Robb A, Rodrigues K, Selby TL, Spraggon G, Stevens RC, Taylor SS, van den Bedem H, Velasquez J, Vincent J, Wang X, West B, Wolf G, Wooley J, Wilson IA: Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins. 2002 Oct 1;49(1):142-5. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01903 5-Bromo-2'-deoxyuridine 5'-(dihydrogen phosphate) experimental unknown Details DB03147 Flavin adenine dinucleotide approved unknown Details DB03761 5-fluoro-2'-deoxyuridine-5'-monophosphate experimental unknown Details DB03800 Deoxyuridine monophosphate experimental unknown Details