Potassium channel subfamily K member 6
Details
- Name
- Potassium channel subfamily K member 6
- Synonyms
- Inward rectifying potassium channel protein TWIK-2
- TOSS
- TWIK-originated similarity sequence
- TWIK2
- Gene Name
- KCNK6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001356|Potassium channel subfamily K member 6 MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALD AFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGK AFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVV VTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTV YLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQL SASSHTDYASIPR
- Number of residues
- 313
- Molecular Weight
- 33746.8
- Theoretical pI
- 6.5
- GO Classification
- Functionsinward rectifier potassium channel activity / potassium ion leak channel activityProcessesnegative regulation of systemic arterial blood pressure / potassium ion transmembrane transport / potassium ion transport / regulation of resting membrane potential / stabilization of membrane potential / synaptic transmissionComponentsintegral component of plasma membrane / plasma membrane / voltage-gated potassium channel complex
- General Function
- Potassium ion leak channel activity
- Specific Function
- Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.
- Pfam Domain Function
- Ion_trans_2 (PF07885)
- Transmembrane Regions
- 5-25 121-141 173-193 236-256
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0016173|Potassium channel subfamily K member 6 (KCNK6) ATGCGGAGGGGCGCGCTTCTGGCGGGCGCCTTGGCCGCGTACGCCGCGTACCTGGTGCTG GGCGCGCTGTTGGTGGCGCGGCTGGAGGGGCCGCACGAAGCCAGGCTCCGAGCCGAGCTG GAGACGCTGCGGGCGCAGCTGCTTCAGCGCAGCCCGTGTGTGGCTGCCCCCGCCCTGGAC GCCTTCGTGGAGCGAGTGCTGGCGGCCGGACGGCTGGGGCGGGTCGTGCTTGCTAACGCT TCGGGGTCCGCCAACGCCTCGGACCCCGCCTGGGACTTCGCCTCTGCTCTCTTCTTCGCC AGCACGCTGATCACCACCGTGGGCTATGGGTACACAACGCCACTGACTGATGCGGGCAAG GCCTTCTCCATCGCCTTTGCGCTCCTGGGCGTGCCGACCACCATGCTGCTGCTGACCGCC TCAGCCCAGCGCCTGTCACTGCTGCTGACTCACGTGCCCCTGTCTTGGCTGAGCATGCGT TGGGGCTGGGACCCCCGGCGGGCGGCCTGCTGGCACTTGGTGGCCCTGTTGGGGGTCGTA GTGACCGTCTGCTTTCTGGTGCCGGCTGTGATCTTTGCCCACCTCGAGGAGGCCTGGAGC TTCTTGGATGCCTTCTACTTCTGCTTTATCTCTCTGTCCACCATCGGCCTGGGCGACTAC GTGCCCGGGGAGGCCCCTGGCCAGCCCTACCGGGCCCTCTACAAGGTGCTGGTCACAGTC TACCTCTTCCTGGGCCTGGTGGCCATGGTGCTGGTGCTGCAGACCTTCCGCCACGTGTCC GACCTCCACGGCCTCACGGAGCTCATCCTGCTGCCCCCTCCGTGCCCTGCCAGTTTCAAT GCGGATGAGGACGATCGGGTGGACATCCTGGGCCCCCAGCCGGAGTCGCACCAGCAACTC TCTGCCAGCTCCCACACCGACTACGCTTCCATCCCCAGGTAG
- Chromosome Location
- 19
- Locus
- 19q13.1
- External Identifiers
Resource Link UniProtKB ID Q9Y257 UniProtKB Entry Name KCNK6_HUMAN GenBank Protein ID 4559312 GenBank Gene ID AF134149 GenAtlas ID KCNK6 HGNC ID HGNC:6281 - General References
- Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, Holmes D, Saganich M, Rudy B, Artman M, Coetzee WA: Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit. FEBS Lett. 1999 May 7;450(3):191-6. [Article]
- Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS: TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. J Biol Chem. 1999 Mar 19;274(12):7887-92. [Article]
- Patel AJ, Maingret F, Magnone V, Fosset M, Lazdunski M, Honore E: TWIK-2, an inactivating 2P domain K+ channel. J Biol Chem. 2000 Sep 15;275(37):28722-30. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]