Potassium channel subfamily K member 6

Details

Name
Potassium channel subfamily K member 6
Synonyms
  • Inward rectifying potassium channel protein TWIK-2
  • TOSS
  • TWIK-originated similarity sequence
  • TWIK2
Gene Name
KCNK6
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001356|Potassium channel subfamily K member 6
MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALD
AFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGK
AFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVV
VTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTV
YLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQL
SASSHTDYASIPR
Number of residues
313
Molecular Weight
33746.8
Theoretical pI
6.5
GO Classification
Functions
inward rectifier potassium channel activity / potassium ion leak channel activity
Processes
negative regulation of systemic arterial blood pressure / potassium ion transmembrane transport / potassium ion transport / regulation of resting membrane potential / stabilization of membrane potential / synaptic transmission
Components
integral component of plasma membrane / plasma membrane / voltage-gated potassium channel complex
General Function
Potassium ion leak channel activity
Specific Function
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.
Pfam Domain Function
Transmembrane Regions
5-25 121-141 173-193 236-256
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0016173|Potassium channel subfamily K member 6 (KCNK6)
ATGCGGAGGGGCGCGCTTCTGGCGGGCGCCTTGGCCGCGTACGCCGCGTACCTGGTGCTG
GGCGCGCTGTTGGTGGCGCGGCTGGAGGGGCCGCACGAAGCCAGGCTCCGAGCCGAGCTG
GAGACGCTGCGGGCGCAGCTGCTTCAGCGCAGCCCGTGTGTGGCTGCCCCCGCCCTGGAC
GCCTTCGTGGAGCGAGTGCTGGCGGCCGGACGGCTGGGGCGGGTCGTGCTTGCTAACGCT
TCGGGGTCCGCCAACGCCTCGGACCCCGCCTGGGACTTCGCCTCTGCTCTCTTCTTCGCC
AGCACGCTGATCACCACCGTGGGCTATGGGTACACAACGCCACTGACTGATGCGGGCAAG
GCCTTCTCCATCGCCTTTGCGCTCCTGGGCGTGCCGACCACCATGCTGCTGCTGACCGCC
TCAGCCCAGCGCCTGTCACTGCTGCTGACTCACGTGCCCCTGTCTTGGCTGAGCATGCGT
TGGGGCTGGGACCCCCGGCGGGCGGCCTGCTGGCACTTGGTGGCCCTGTTGGGGGTCGTA
GTGACCGTCTGCTTTCTGGTGCCGGCTGTGATCTTTGCCCACCTCGAGGAGGCCTGGAGC
TTCTTGGATGCCTTCTACTTCTGCTTTATCTCTCTGTCCACCATCGGCCTGGGCGACTAC
GTGCCCGGGGAGGCCCCTGGCCAGCCCTACCGGGCCCTCTACAAGGTGCTGGTCACAGTC
TACCTCTTCCTGGGCCTGGTGGCCATGGTGCTGGTGCTGCAGACCTTCCGCCACGTGTCC
GACCTCCACGGCCTCACGGAGCTCATCCTGCTGCCCCCTCCGTGCCCTGCCAGTTTCAAT
GCGGATGAGGACGATCGGGTGGACATCCTGGGCCCCCAGCCGGAGTCGCACCAGCAACTC
TCTGCCAGCTCCCACACCGACTACGCTTCCATCCCCAGGTAG
Chromosome Location
19
Locus
19q13.1
External Identifiers
ResourceLink
UniProtKB IDQ9Y257
UniProtKB Entry NameKCNK6_HUMAN
GenBank Protein ID4559312
GenBank Gene IDAF134149
GenAtlas IDKCNK6
HGNC IDHGNC:6281
General References
  1. Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, Holmes D, Saganich M, Rudy B, Artman M, Coetzee WA: Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit. FEBS Lett. 1999 May 7;450(3):191-6. [Article]
  2. Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS: TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. J Biol Chem. 1999 Mar 19;274(12):7887-92. [Article]
  3. Patel AJ, Maingret F, Magnone V, Fosset M, Lazdunski M, Honore E: TWIK-2, an inactivating 2P domain K+ channel. J Biol Chem. 2000 Sep 15;275(37):28722-30. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00308IbutilideapprovedunknowninhibitorDetails
DB00908Quinidineapproved, investigationalunknowninhibitorDetails