Phospholipid-transporting ATPase IA
Details
- Name
- Phospholipid-transporting ATPase IA
- Synonyms
- 3.6.3.1
- ATPase class I type 8A member 1
- ATPIA
- Chromaffin granule ATPase II
- P4-ATPase flippase complex alpha subunit ATP8A1
- Gene Name
- ATP8A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001993|Phospholipid-transporting ATPase IA MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYN IITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIED IKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAM CYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGH GTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILI LFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLL VTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQ FKKCTIAGVAYGHVPEPEDYGCSPDEWQNSQFGDEKTFSDSSLLENLQNNHPTAPIICEF LTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEER YELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEITLKHLEQFA TEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIE DKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTR ETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQ KSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYL KNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMF TAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPL KALQYGTAFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVV FFGIYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIKRTAFKTL VDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHGYAFSQD ENGIVSQSEVIRAYDTTKQRPDEW
- Number of residues
- 1164
- Molecular Weight
- 131368.215
- Theoretical pI
- 6.83
- GO Classification
- FunctionsATP binding / cation-transporting ATPase activity / magnesium ion binding / phospholipid-translocating ATPase activityProcessescation transmembrane transport / ion transmembrane transport / learning / phospholipid translocation / positive regulation of cell migration / positive regulation of phospholipid translocation / transmembrane transportComponentschromaffin granule membrane / endoplasmic reticulum / extracellular exosome / Golgi apparatus / integral component of membrane / intracellular membrane-bounded organelle / membrane / plasma membrane
- General Function
- Phospholipid-translocating atpase activity
- Specific Function
- Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.
- Pfam Domain Function
- Transmembrane Regions
- 66-86 93-115 298-319 345-366 858-878 891-910 941-962 977-999 1006-1026 1045-1070
- Cellular Location
- Cytoplasmic vesicle
- Gene sequence
>lcl|BSEQ0019050|Phospholipid-transporting ATPase IA (ATP8A1) ATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTCGCGCGCCGAAGGTTATGAGAAG ACAGATGATGTTTCAGAGAAGACCTCACTGGCTGACCAGGAGGAAGTAAGGACTATTTTC ATCAACCAGCCCCAGCTGACAAAATTCTGCAATAACCATGTCAGCACTGCAAAATACAAC ATAATCACATTCCTTCCAAGATTTCTCTACTCTCAGTTCAGAAGAGCTGCTAATTCATTT TTTCTCTTTATTGCACTGCTGCAGCAAATACCTGATGTGTCACCAACAGGTCGTTATACA ACACTGGTTCCTCTCTTATTTATTTTAGCTGTGGCAGCTATCAAAGAGATAATAGAAGAT ATTAAACGACATAAAGCTGATAATGCAGTGAACAAGAAACAAACGCAAGTTTTGAGAAAT GGTGCTTGGGAAATTGTCCACTGGGAAAAGGTAAATGTTGGAGATATAGTTATAATAAAA GGCAAAGAGTATATACCTGCTGACACTGTACTTCTCTCATCAAGTGAGCCCCAAGCCATG TGCTACATTGAAACATCCAACTTAGATGGTGAAACAAACTTGAAAATTAGACAGGGCTTA CCAGCAACATCAGATATCAAAGACGTTGACAGTTTGATGAGGATTTCTGGCAGAATTGAG TGTGAAAGTCCAAACAGACATCTCTACGATTTTGTTGGAAACATAAGGCTTGATGGACAT GGCACCGTTCCACTGGGAGCAGATCAGATTCTTCTTCGAGGAGCTCAGTTGAGAAATACA CAGTGGGTTCATGGAATAGTTGTCTACACTGGACATGACACCAAGCTGATGCAGAATTCA ACAAGTCCACCACTTAAGCTCTCAAATGTGGAACGGATTACAAATGTACAAATTTTGATT TTATTTTGTATCTTAATTGCCATGTCTCTTGTCTGTTCTGTGGGCTCAGCCATTTGGAAT CGAAGGCATTCTGGAAAAGACTGGTATCTCAATCTAAACTATGGTGGCGCTAGTAATTTT GGACTGAATTTCTTGACCTTCATCATCCTTTTCAACAATCTCATTCCTATCAGCTTATTG GTTACATTAGAAGTTGTGAAATTTACCCAGGCATACTTCATAAATTGGGATCTTGACATG CACTATGAACCCACAGACACTGCTGCTATGGCTCGAACATCTAATCTGAATGAGGAACTT GGCCAGGTTAAATACATATTTTCTGACAAAACTGGTACTCTGACATGCAATGTAATGCAG TTTAAGAAGTGCACCATAGCGGGAGTTGCTTATGGGCAGAACTCACAGTTTGGAGATGAA AAAACATTTAGTGATTCATCATTGCTGGAAAATCTCCAAAATAATCATCCAACTGCACCT ATAATATGTGAATTTCTTACAATGATGGCAGTCTGTCACACAGCAGTGCCAGAGCGAGAA GGTGACAAGATTATTTATCAAGCAGCATCTCCAGATGAGGGAGCATTGGTCAGAGCAGCC AAGCAATTGAATTTTGTTTTCACTGGAAGAACACCCGACTCGGTGATTATAGATTCACTG GGGCAGGAAGAAAGATATGAATTGCTCAATGTCTTGGAGTTTACCAGTGCTAGGAAAAGA ATGTCAGTGATTGTTCGCACTCCATCTGGAAAGTTACGACTCTACTGCAAAGGAGCTGAC ACTGTAATTTATGATCGACTGGCAGAGACGTCAAAATACAAAGAAATTACCCTAAAACAT TTAGAGCAGTTTGCTACAGAAGGGTTAAGAACTTTATGTTTTGCTGTGGCTGAGATTTCA GAGAGCGACTTTCAGGAGTGGCGAGCAGTCTATCAGCGAGCATCTACATCTGTGCAGAAC AGGCTACTCAAACTCGAAGAGAGTTATGAGTTGATTGAAAAGAATCTTCAGCTACTTGGA GCAACAGCCATTGAGGATAAATTACAAGATCAAGTGCCTGAAACCATAGAAACGCTAATG AAAGCAGACATCAAAATCTGGATCCTTACAGGGGACAAGCAAGAAACTGCCATTAACATC GGACACTCCTGCAAACTGTTGAAGAAGAACATGGGAATGATTGTTATAAATGAAGGCTCT CTTGATGGAACAAGGGAAACTCTCAGTCGTCACTGTACTACCCTTGGTGATGCTCTCCGG AAAGAGAATGATTTTGCTCTTATAATTGATGGGAAAACCCTCAAATATGCCTTAACCTTT GGAGTACGACAGTATTTCCTGGACTTAGCTTTGTCATGCAAAGCTGTCATTTGCTGTCGG GTTTCTCCTCTTCAAAAATCTGAAGTTGTTGAGATGGTTAAGAAACAAGTCAAAGTCGTA ACGCTTGCAATCGGTGATGGAGCAAATGATGTCAGCATGATACAGACAGCGCACGTTGGT GTTGGTATCAGTGGCAATGAAGGCCTGCAGGCAGCTAATTCCTCTGACTACTCCATAGCT CAGTTCAAATATTTGAAGAATTTACTGATGATTCATGGTGCCTGGAACTATAACAGAGTC TCCAAGTGCATCTTATACTGCTTCTACAAGAATATAGTGCTCTATATTATCGAGATCTGG TTTGCCTTTGTTAATGGCTTTTCTGGACAGATCCTCTTTGAAAGATGGTGTATAGGTCTC TATAACGTGATGTTTACAGCAATGCCTCCTTTAACTCTTGGAATATTTGAGAGATCATGC AGAAAAGAGAACATGTTGAAGTACCCTGAATTATACAAAACATCTCAGAATGCCCTGGAC TTCAACACCAAGGTTTTCTGGGTTCATTGTTTAAATGGCCTCTTCCACTCAGTTATTCTG TTTTGGTTTCCACTAAAAGCCCTTCAGTATGGTACTGCATTTGGAAATGGGAAAACCTCG GATTATCTGCTACTGGGAAACTTTGTGTACACTTTTGTGGTGATAACTGTGTGTTTGAAA GCTGGATTGGAGACATCATATTGGACATGGTTCAGCCACATAGCGATATGGGGGAGCATC GCACTCTGGGTGGTGTTTTTTGGAATCTACTCATCTCTGTGGCCTGCCATTCCGATGGCC CCTGATATGTCAGGAGAGGCAGCCATGTTGTTCAGTTCTGGAGTCTTTTGGATGGGCTTG TTATTCATCCCTGTGGCATCTCTGCTCCTTGATGTGGTGTACAAGGTTATCAAGAGGACT GCTTTTAAAACATTGGTCGATGAAGTTCAGGAGCTGGAGGCAAAATCTCAAGACCCAGGA GCAGTTGTACTTGGAAAAAGCCTGACCGAGAGGGCGCAACTGCTCAAGAACGTCTTTAAG AAGAACCACGTGAACTTGTACCGCTCTGAATCCTTGCAACAAAATCTGCTCCATGGGTAT GCGTTCTCTCAAGATGAAAATGGAATCGTTTCACAGTCTGAAGTGATAAGAGCATATGAT ACCACGAAACAGAGGCCCGACGAATGGTGA
- Chromosome Location
- 4
- Locus
- 4p14-p12
- External Identifiers
Resource Link UniProtKB ID Q9Y2Q0 UniProtKB Entry Name AT8A1_HUMAN GenBank Protein ID 4972583 GenBank Gene ID AF067820 GenAtlas ID ATP8A1 HGNC ID HGNC:13531 - General References
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- van der Velden LM, Wichers CG, van Breevoort AE, Coleman JA, Molday RS, Berger R, Klomp LW, van de Graaf SF: Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. J Biol Chem. 2010 Dec 17;285(51):40088-96. doi: 10.1074/jbc.M110.139006. Epub 2010 Oct 14. [Article]
- Bryde S, Hennrich H, Verhulst PM, Devaux PF, Lenoir G, Holthuis JC: CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery. J Biol Chem. 2010 Dec 24;285(52):40562-72. doi: 10.1074/jbc.M110.139543. Epub 2010 Oct 20. [Article]
- Takatsu H, Baba K, Shima T, Umino H, Kato U, Umeda M, Nakayama K, Shin HW: ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. J Biol Chem. 2011 Nov 4;286(44):38159-67. doi: 10.1074/jbc.M111.281006. Epub 2011 Sep 13. [Article]