Lethal(3)malignant brain tumor-like protein 1
Details
- Name
- Lethal(3)malignant brain tumor-like protein 1
- Synonyms
- H-l(3)mbt
- KIAA0681
- L(3)mbt protein homolog
- L3MBT
- L3MBTL
- L3MBTL1
- Gene Name
- L3MBTL1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037223|Lethal(3)malignant brain tumor-like protein 1 MRRREGHGTDSEMGQGPVRESQSSDPPALQFRISEYKPLNMAGVEQPPSPELRQEGVTEY EDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDG CPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEG QPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKL GMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTG HKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPS LVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPD NFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIK IHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLP HTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASAR KKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSV CWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEMIDGEAFLLLTQ ADIVKIMSVKLGPALKIYNAILMFKNADDTLK
- Number of residues
- 752
- Molecular Weight
- 83882.985
- Theoretical pI
- 6.04
- GO Classification
- Functionschromatin binding / histone binding / identical protein binding / methylated histone binding / nucleosomal histone binding / nucleosome binding / SAM domain binding / transcription factor activity, sequence-specific DNA binding / zinc ion bindingProcesseschromatin modification / hemopoiesis / negative regulation of transcription, DNA-templated / regulation of cell cycle / regulation of megakaryocyte differentiation / regulation of mitotic nuclear division / transcription, DNA-templatedComponentschromatin / condensed chromosome / nucleoplasm / nucleus / plasma membrane
- General Function
- Zinc ion binding
- Specific Function
- Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0021350|Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) ATGAGGCGAAGAGAGGGCCATGGCACCGACTCCGAGATGGGTCAAGGACCCGTACGGGAG TCGCAATCCTCAGACCCTCCCGCGCTCCAGTTCCGGATAAGCGAGTATAAGCCGCTGAAC ATGGCGGGAGTGGAGCAGCCCCCGAGCCCCGAGCTGCGGCAGGAAGGCGTGACCGAATAC GAAGATGGCGGGGCCCCGGCGGGAGATGGCGAGGCGGGCCCCCAACAGGCGGAGGACCAC CCCCAGAATCCTCCAGAAGATCCCAATCAGGACCCCCCAGAGGATGATAGCACCTGTCAG TGCCAGGCGTGCGGGCCTCACCAAGCCGCGGGTCCAGATCTTGGTTCCTCTAATGATGGC TGCCCTCAGCTGTTCCAGGAGCGGTCAGTCATAGTGGAGAACTCCTCAGGCTCTACCAGC GCTTCTGAGCTCCTCAAACCCATGAAGAAGAGGAAGCGCAGGGAATACCAGAGCCCATCA GAGGAGGAGTCGGAGCCAGAGGCCATGGAGAAGCAAGAAGAAGGAAAGGACCCAGAGGGA CAACCCACTGCTAGCACCCCAGAGAGTGAGGAGTGGAGCAGCAGCCAGCCTGCAACAGGT GAGAAGAAGGAATGCTGGTCGTGGGAGTCCTACCTAGAGGAGCAGAAGGCCATTACTGCT CCAGTCAGCCTCTTCCAGGACTCCCAGGCAGTCACTCACAACAAGAATGGCTTCAAACTG GGCATGAAGTTGGAAGGCATTGACCCTCAACACCCGTCCATGTACTTCATCCTCACCGTG GCTGAGGTATGTGGCTATCGCCTACGCCTGCACTTTGATGGGTATTCTGAGTGCCATGAC TTCTGGGTCAATGCCAACTCCCCTGACATTCACCCTGCTGGCTGGTTCGAGAAGACGGGC CACAAGCTGCAGCCTCCCAAAGGTTACAAGGAGGAGGAGTTCAGCTGGAGCCAGTACCTG CGCAGCACAAGAGCTCAGGCTGCCCCCAAGCACCTGTTTGTGAGCCAGAGCCACAGTCCC CCACCCCTGGGCTTCCAGGTGGGCATGAAGCTGGAGGCTGTTGACCGCATGAACCCGTCC CTTGTCTGCGTGGCCAGTGTGACCGATGTGGTGGACAGCCGCTTCCTGGTGCACTTTGAC AACTGGGATGATACTTATGACTACTGGTGTGATCCCAGCAGCCCCTACATCCACCCAGTG GGCTGGTGCCAGAAGCAAGGAAAGCCCCTCACCCCTCCACAAGACTACCCAGACCCTGAT AACTTCTGTTGGGAGAAATATCTGGAAGAAACTGGGGCCTCTGCTGTCCCCACCTGGGCC TTCAAGGTGCGACCCCCTCACAGCTTCCTGGTCAATATGAAGCTGGAGGCTGTGGACCGC AGGAACCCAGCCCTGATTCGCGTGGCCAGCGTGGAGGATGTGGAGGACCATCGGATAAAG ATCCACTTTGATGGCTGGAGTCATGGCTATGATTTCTGGATCGACGCTGACCACCCAGAC ATCCACCCTGCCGGCTGGTGCTCCAAGACAGGACATCCCCTGCAGCCTCCTCTCGGACCC AGAGAGCCCAGCTCTGCCTCCCCTGGGGGCTGTCCCCCTCTCAGCTATAGGAGCCTGCCC CACACTAGGACCTCCAAATACAGCTTTCACCACCGGAAGTGCCCCACTCCTGGTTGCGAC GGCTCTGGCCATGTCACAGGCAAGTTCACAGCTCACCATTGCCTCTCAGGCTGCCCACTG GCTGAGAGGAACCAGAGCCGGCTGAAAGCGGAGCTGTCTGACTCGGAGGCCTCAGCCCGC AAGAAGAACCTCTCAGGCTTCTCCCCAAGGAAGAAGCCTCGCCATCACGGCCGAATTGGA CGCCCTCCGAAGTATCGAAAGATTCCGCAGGAAGATTTCCAGACCCTCACGCCCGATGTC GTGCACCAGTCCCTCTTCATGTCAGCCCTGTCGGCCCACCCTGACCGCTCACTCTCAGTG TGCTGGGAGCAGCACTGCAAGCTCCTGCCAGGAGTAGCGGGCATCTCAGCCTCGACAGTC GCCAAGTGGACCATCGATGAGGTCTTCGGCTTTGTTCAGACCCTGACAGGTTGTGAGGAC CAAGCACGCCTCTTCAAAGACGAGGCAAGAATAGTCAGAGTGACCCATGTATCTGGGAAG ACTCTAGTCTGGACTGTGGCCCAGCTTGGGGACCTTGTGTGCTCAGATCATCTTCAGGAA GGAAAAGGCATCCTGGAGACAGGAGTCCATTCACTCCTCTGCTCTCTACCCACTCATTTG CTTGCCAAACTTAGCTTTGCCAGTGATAGTCAATATTAA
- Chromosome Location
- 20
- Locus
- 20q13.12
- External Identifiers
Resource Link UniProtKB ID Q9Y468 UniProtKB Entry Name LMBL1_HUMAN GenBank Gene ID U89358 GenAtlas ID L3MBTL HGNC ID HGNC:15905 - General References
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