Fibroblast Growth Factors

Name
Fibroblast Growth Factors
Accession Number
DBCAT000119
Description

A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.

Drugs
DrugDrug Description
PaliferminA form of recombinant human keratinocyte growth factor used to prevent and treat oral mucositis following radiation or chemotherapy.
Fibroblast growth factor-1Investigated for use/treatment in coronary artery disease and peripheral vascular disease.
RepiferminInvestigated for use/treatment in bone marrow transplant, ulcers, and inflammatory bowel disease.
Basic Fibroblast Growth FactorBasic Fibroblast Growth Factor is not currently approved for any FDA or Health Canada approved indications.
TraferminInvestigated for use/treatment in coronary artery disease, peripheral vascular disease, periodontal disease, bone fractures, entero-related fistulae, and diabetic foot ulcers.
Drugs & Drug Targets
DrugTargetType
PaliferminFibroblast growth factor receptor 2target
PaliferminFibroblast growth factor receptor 1target
PaliferminBasement membrane-specific heparan sulfate proteoglycan core proteintarget