Proto-Oncogene Proteins

Accession Number

DBCAT000210

Description

Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.

Drugs

Drug	Drug Description
Becaplermin	A recombinant form of human platelet-derived growth factor used to treat ulcers due to diabetic neuropathy in the lower extremities when there is adequate blood supply to the area.
Nelipepimut-S	Investigated for use/treatment in prostate cancer and breast cancer.

Drugs & Drug Targets

Drug	Target	Type
Becaplermin	Platelet-derived growth factor receptor beta	target
Becaplermin	Alpha-2-macroglobulin	target
Becaplermin	Platelet-derived growth factor receptor alpha	target
Nelipepimut-S	HLA class I histocompatibility antigen, A-2 alpha chain	target
Nelipepimut-S	HLA class I histocompatibility antigen, A-3 alpha chain	target