Antifibrinolytic Agents

Name
Antifibrinolytic Agents
Accession Number
DBCAT000387
Description

Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.

ATC Classification
Drugs
DrugDrug Description
Tranexamic acidAn antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders.
Aminocaproic acidAn antifibrinolytic agent used to induce clotting postoperatively.
AprotininA serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery.
MenadioneThe primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.
Alpha-1-proteinase inhibitorA purified form of human alpha-1 proteinase inhibitor used to treat emphysema patients with associated alpha-1 proteinase inhibitor deficiency.
Aminomethylbenzoic acidAminomethylbenzoic acid may be useful as an antifibrinolytic agent .
CamostatA serine protease indicated in Japan to treat chronic pancreatitis.
Hydrogen peroxideA compound used as a disinfectant and sterilizer.
UlinastatinUlinastatin has been investigated for the prevention of Cardiovascular Disease and Adverse Reaction to Drug.
Menadione bisulfiteNot Annotated
Drugs & Drug Targets
DrugTargetType
Tranexamic acidPlasminogentarget
Aminocaproic acidPlasminogentarget
Aminocaproic acidTissue-type plasminogen activatortarget
Aminocaproic acidApolipoprotein(a)target
Aminocaproic acidAldehyde oxidaseenzyme
AprotininTrypsin-1target
AprotininChymotrypsinogen Btarget
AprotininPlasminogentarget
AprotininKallikrein-1target
AprotininCholinesteraseenzyme
MenadioneProthrombintarget
MenadioneVitamin K epoxide reductase complex subunit 1target
MenadioneCoagulation factor IXtarget
MenadioneVitamin K-dependent gamma-carboxylasetarget
MenadioneVitamin K-dependent protein Ctarget
MenadioneVitamin K-dependent protein Starget
MenadioneNAD(P)H dehydrogenase [quinone] 1target
MenadioneRibosyldihydronicotinamide dehydrogenase [quinone]target
MenadioneVitamin K epoxide reductase complex subunit 1-like protein 1target
MenadioneXanthine dehydrogenase/oxidaseenzyme
MenadioneAldehyde oxidaseenzyme
MenadioneMethylenetetrahydrofolate reductaseenzyme
MenadioneCytochrome P450 1A1enzyme
MenadioneOsteocalcintarget
MenadioneCytochrome P450 1A2enzyme
MenadioneCytochrome P450 2A6enzyme
MenadioneCytochrome P450 1B1enzyme
MenadioneCytochrome P450 2B6enzyme
MenadioneCytochrome P450 2C8enzyme
MenadioneCytochrome P450 2C9enzyme
MenadioneCytochrome P450 2C19enzyme
MenadioneCytochrome P450 2D6enzyme
MenadioneCytochrome P450 2E1enzyme
MenadioneCytochrome P450 3A4enzyme
MenadioneCytochrome P450 3A5enzyme
MenadioneCytochrome P450 3A7enzyme
Alpha-1-proteinase inhibitorNeutrophil elastasetarget
CamostatTrypsin-1target
CamostatTransmembrane protease serine 2target
CamostatSuppressor of tumorigenicity 14 proteintarget
CamostatCholecystokinintarget
Hydrogen peroxideGlutathione peroxidase 1enzyme
Hydrogen peroxideCatalaseenzyme
Hydrogen peroxideAlkaline phosphatase, germ cell typeenzyme