Dihydroxyphenylalanine

Accession Number

DBCAT000464

Description

A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.

Drugs

Drug	Drug Description
Methyldopa	A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises.
Levodopa	A dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism.
Etilevodopa	Investigated for use/treatment in parkinson's disease.
Melevodopa	A methyl ester of levodopa indicated in combination with carbidopa for the treatment of Parkinson's disease.

Drugs & Drug Targets

Drug	Target	Type
Methyldopa	Alpha-2A adrenergic receptor	target
Methyldopa	Catechol O-methyltransferase	enzyme
Methyldopa	Solute carrier family 15 member 1	transporter
Methyldopa	Aromatic-L-amino-acid decarboxylase	target
Methyldopa	Serum albumin	carrier
Methyldopa	Sulfotransferase	enzyme
Methyldopa	Dopamine beta-hydroxylase	enzyme
Methyldopa	Phenylethanolamine N-methyltransferase	enzyme
Methyldopa	Aromatic-L-amino-acid decarboxylase	enzyme
Levodopa	Dopamine D1 receptor	target
Levodopa	Dopamine D2 receptor	target
Levodopa	Aromatic-L-amino-acid decarboxylase	enzyme
Levodopa	Solute carrier family 15 member 1	transporter
Levodopa	Monocarboxylate transporter 10	transporter
Levodopa	Dopamine D3 receptor	target
Levodopa	Dopamine D4 receptor	target
Levodopa	Dopamine D5 receptor	target
Levodopa	Large neutral amino acids transporter small subunit 1	transporter
Levodopa	Large neutral amino acids transporter small subunit 2	transporter
Levodopa	Serum albumin	carrier