Biogenic Monoamines

Name
Biogenic Monoamines
Accession Number
DBCAT000468
Description

Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.

Drugs
DrugDrug Description
CarbidopaA dopa decarboxylase inhibitor used in combination with levodopa for the symptomatic treatment of idiopathic Parkinson disease and other conditions associated with parkinsonian symptoms.
ZolmitriptanA member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults.
DipivefrinA prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma.
EpinephrineA hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.
SumatriptanA serotonin receptor agonist used to treat migraines and cluster headaches.
DopamineA catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension.
MelatoninAn endogenous hormone produced by the pineal gland that regulates sleep-wake cycles and when provided exogenously has beneficial effects on sleep-onset latency; available as an over-the-counter supplement.
LevodopaA dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism.
TyramineTyramine (4-hydroxyphenethylamine; para-tyramine, mydrial or uteramin) is a naturally occurring monoamine compound and trace amine derived from the amino acid tyrosine. Tyramine acts by inducing the release of catecholamine. An...
AlprazolamA triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression.
NorepinephrineA sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest.
HistamineAn ingredient of topical drugs for the relief of joint pain or muscle aches and pains.
AmphetamineA CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
EletriptanA triptan used for the treatment of migraines.
AlmotriptanA 5-HT1B/1D receptor agonist used to treat migraines.
NaratriptanA 5-HT1B/1D receptor agonist used to treat migraines.
RizatriptanA triptan used to treat migraines with or without aura.
FrovatriptanA 5-HT1B/1D receptor agonist used to treat migraines.
5-Methoxy-N,N-diisopropyltryptamine5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, psilocybin and psilocin. Since 1999, there has been a...
IndopanIndopan (alpha-methyltryptamine) is a stimulant and psychoactive drug which produces effects similar to 3,4-methylenedioxy-N-methylamphetamine (MDMA), despite being structurally dissimilar. It was developed in the 1960's by Upjohn with the intention...
DiethyltryptamineDiethyltryptamine (DET) is an orally active hallucinogenic agent and a substituted form of tryptamine.
DimethyltryptamineSome people use this compound as a psychedelic inducing agent.
EtryptamineDeveloped in the 1960's for use as an antidepressant before market withdrawal in 1962.
N-acetylserotoninNot Available
N-acetylhistamineNot Available
ProtokylolProtokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States.
TryptamineNot Available
N-CaffeoyltyramineNot Available
SerotoninFor temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product.
SynephrineSynephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer...
RacepinephrineA bronchodilator used to treat intermittent asthma.
SerdemetanSerdemetan has been used in trials studying the treatment of Neoplasms.
DopexamineDopexamine has been used in trials studying the diagnostic and treatment of Free Flap, Oral Cancer, Hypotension, Septic Shock, and Head and Neck Cancer.
TheodrenalineTheodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation).
OctopamineOctopamine is structurally similar to norepinephrine. It has been used as a nootropic, and therefore it and all of its enantiomer are prohibited by the World Anti-doping Agency (WADA) as...
NorfenefrineNot Annotated
AdrenaloneNot Annotated
5-methoxy-N,N-dimethyltryptamine5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a tryptamine with psychedelic properties. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. This drug,...
Tyramine O-sulfateNot Annotated
Histamine glutarimideHistamine glutarimide is under investigation in clinical trial NCT03450434 (XC8 in the Treatment of Patients With Bronchial Asthma).
DopastatinDopastatin is under investigation in clinical trial NCT04335357 (TBR-760 in Adult Patients With Non-functioning Pituitary Adenomas).
N-oleoyldopamineN-oleoyldopamine (OLDA) is an amide of dopamine and oleic acid.
DocarpamineNot Available
Drugs & Drug Targets
DrugTargetType
CarbidopaAromatic-L-amino-acid decarboxylasetarget
Zolmitriptan5-hydroxytryptamine receptor 1Dtarget
Zolmitriptan5-hydroxytryptamine receptor 1Btarget
Zolmitriptan5-hydroxytryptamine receptor 1Ftarget
ZolmitriptanCytochrome P450 1A2enzyme
ZolmitriptanAmine oxidase [flavin-containing] Aenzyme
Zolmitriptan5-hydroxytryptamine receptor 1Atarget
ZolmitriptanP-glycoprotein 1transporter
Zolmitriptan5-hydroxytryptamine receptor 7target
Zolmitriptan5-hydroxytryptamine receptor 2Atarget
Zolmitriptan5-hydroxytryptamine receptor 2Btarget
Zolmitriptan5-hydroxytryptamine receptor 1Etarget
DipivefrinAlpha-2A adrenergic receptortarget
DipivefrinCholinesterasetarget
DipivefrinBeta-2 adrenergic receptortarget
DipivefrinAlpha-1A adrenergic receptortarget
DipivefrinAcetylcholinesterasetarget
EpinephrineAlpha-1A adrenergic receptortarget
EpinephrineBeta-1 adrenergic receptortarget
EpinephrineBeta-2 adrenergic receptortarget
EpinephrineSolute carrier family 22 member 2transporter
EpinephrineSolute carrier family 22 member 1transporter
EpinephrineCytochrome P450 2C9enzyme
EpinephrineCytochrome P450 3A4enzyme
EpinephrineAlpha-1B adrenergic receptortarget
EpinephrineAlpha-1D adrenergic receptortarget
EpinephrineAlpha-2A adrenergic receptortarget
EpinephrineAlpha-2B adrenergic receptortarget
EpinephrineTumor necrosis factortarget
EpinephrineCatechol O-methyltransferaseenzyme
EpinephrineMonoamine oxidaseenzyme
Sumatriptan5-hydroxytryptamine receptor 1Dtarget
Sumatriptan5-hydroxytryptamine receptor 1Btarget
Sumatriptan5-hydroxytryptamine receptor 1Ftarget
SumatriptanAmine oxidase [flavin-containing] Aenzyme
Sumatriptan5-hydroxytryptamine receptor 1Atarget
SumatriptanSolute carrier organic anion transporter family member 1A2transporter
SumatriptanP-glycoprotein 1transporter
SumatriptanATP-binding cassette sub-family G member 2transporter
SumatriptanSolute carrier organic anion transporter family member 1B1transporter
DopamineDopamine D1 receptortarget
DopamineDopamine beta-hydroxylasetarget
DopamineAmine oxidase [flavin-containing] Aenzyme
DopamineAmine oxidase [flavin-containing] Benzyme
DopamineCatechol O-methyltransferaseenzyme
DopamineSolute carrier family 22 member 2transporter
DopamineSolute carrier family 22 member 1transporter
DopamineSolute carrier family 22 member 3transporter
DopamineSolute carrier family 22 member 5transporter
DopaminePOU domain, class 5, transcription factor 1transporter
DopamineDopamine D5 receptortarget
DopamineDopamine D2 receptortarget
DopamineDopamine D3 receptortarget
DopamineDopamine D4 receptortarget
DopamineSodium-dependent dopamine transportertarget
DopamineDopamine beta-hydroxylaseenzyme
Dopamine5-hydroxytryptamine receptor 1Atarget
Dopamine5-hydroxytryptamine receptor 7target
DopamineD(1) dopamine receptortarget
DopamineSodium-dependent noradrenaline transportertarget
DopamineSodium-dependent serotonin transportertarget
Dopamine5-hydroxytryptamine receptor 3Atarget
Dopamine5-hydroxytryptamine receptor 3Btarget
DopamineSuperoxide dismutase [Cu-Zn]target
DopamineSynaptic vesicular amine transportertarget
MelatoninAcetylserotonin O-methyltransferasetarget
MelatoninMelatonin receptor type 1Atarget
MelatoninMelatonin receptor type 1Btarget
MelatoninNuclear receptor ROR-betatarget
MelatoninCalmodulintarget
MelatoninCalreticulintarget
MelatoninRibosyldihydronicotinamide dehydrogenase [quinone]target
MelatoninMyeloperoxidasetarget
MelatoninEstrogen receptor alphatarget
MelatoninEosinophil peroxidasetarget
MelatoninCytochrome P450 1A1enzyme
MelatoninCytochrome P450 1A2enzyme
MelatoninCytochrome P450 2C19enzyme
MelatoninCytochrome P450 2C9enzyme
MelatoninAcetylserotonin O-methyltransferaseenzyme
MelatoninIndoleamine 2,3-dioxygenase 1enzyme
MelatoninMyeloperoxidaseenzyme
MelatoninCytochrome P450 1B1enzyme
MelatoninSolute carrier family 22 member 8transporter
MelatoninCytochrome P450 19A1enzyme
LevodopaDopamine D1 receptortarget
LevodopaDopamine D2 receptortarget
LevodopaAromatic-L-amino-acid decarboxylaseenzyme
LevodopaSolute carrier family 15 member 1transporter
LevodopaMonocarboxylate transporter 10transporter
LevodopaDopamine D3 receptortarget
LevodopaDopamine D4 receptortarget
LevodopaDopamine D5 receptortarget
LevodopaLarge neutral amino acids transporter small subunit 1transporter
LevodopaLarge neutral amino acids transporter small subunit 2transporter
LevodopaSerum albumincarrier
TyramineSolute carrier family 22 member 3transporter
AlprazolamCytochrome P450 3A4enzyme
AlprazolamCytochrome P450 2C9enzyme
AlprazolamCytochrome P450 3A5enzyme
AlprazolamCytochrome P450 3A7enzyme
AlprazolamGABA(A) Receptortarget
AlprazolamSerum albumincarrier
Alprazolamalpha1-acid glycoproteincarrier
AlprazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
NorepinephrinePhenylalanine-4-hydroxylasetarget
NorepinephrineAlpha-1A adrenergic receptortarget
NorepinephrineAlpha-1B adrenergic receptortarget
NorepinephrineAlpha-1D adrenergic receptortarget
NorepinephrineAlpha-2A adrenergic receptortarget
NorepinephrineAlpha-2B adrenergic receptortarget
NorepinephrineAlpha-2C adrenergic receptortarget
NorepinephrineBeta-1 adrenergic receptortarget
NorepinephrineBeta-2 adrenergic receptortarget
NorepinephrineBeta-3 adrenergic receptortarget
NorepinephrineSolute carrier family 22 member 2transporter
NorepinephrineSolute carrier family 22 member 3transporter
NorepinephrineSolute carrier family 22 member 5transporter
NorepinephrineSolute carrier family 22 member 1transporter
NorepinephrinePOU domain, class 5, transcription factor 1transporter
NorepinephrineSodium-dependent noradrenaline transportertransporter
NorepinephrineSynaptic vesicular amine transportertarget
NorepinephrineChromaffin granule amine transportertarget
HistamineHistamine H1 receptortarget
HistamineHistamine H2 receptortarget
HistamineHistamine H3 receptortarget
HistamineHistamine N-methyltransferaseenzyme
HistamineSolute carrier family 22 member 2transporter
HistamineSolute carrier family 22 member 1transporter
HistamineSolute carrier family 22 member 3transporter
HistamineSolute carrier family 22 member 5transporter
HistamineHistamine H4 receptortarget
HistamineSynaptic vesicular amine transportertarget
AmphetamineSodium-dependent dopamine transportertarget
AmphetamineCocaine- and amphetamine-regulated transcript proteintarget
AmphetamineTrace amine-associated receptor 1target
AmphetamineCytochrome P450 2D6enzyme
AmphetamineSolute carrier family 22 member 3transporter
AmphetamineSolute carrier family 22 member 5transporter
AmphetamineSynaptic vesicular amine transportertarget
AmphetamineCytochrome P450 2A6enzyme
AmphetamineSodium-dependent noradrenaline transportertarget
AmphetamineAlpha adrenergic receptortarget
AmphetamineBeta adrenergic receptortarget
AmphetamineDopamine D2 receptortarget
AmphetamineAmine oxidase [flavin-containing] Btarget
AmphetamineSodium-dependent serotonin transportertarget
AmphetamineMonoamine oxidasetarget
Eletriptan5-hydroxytryptamine receptor 1Dtarget
Eletriptan5-hydroxytryptamine receptor 1Atarget
Eletriptan5-hydroxytryptamine receptor 1Ftarget
Eletriptan5-hydroxytryptamine receptor 1Btarget
EletriptanCytochrome P450 3A4enzyme
EletriptanCytochrome P450 2D6enzyme
EletriptanCytochrome P450 2C9enzyme
EletriptanCytochrome P450 2C19enzyme
EletriptanProstaglandin G/H synthase 1enzyme
EletriptanCytochrome P450 2A6enzyme
EletriptanP-glycoprotein 1transporter
Almotriptan5-hydroxytryptamine receptor 1Dtarget
Almotriptan5-hydroxytryptamine receptor 1Btarget
AlmotriptanCytochrome P450 3A4enzyme
AlmotriptanCytochrome P450 2D6enzyme
AlmotriptanAmine oxidase [flavin-containing] Aenzyme
AlmotriptanDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
AlmotriptanCytochrome P450 2C19enzyme
AlmotriptanCytochrome P450 2E1enzyme
AlmotriptanCytochrome P450 2C8enzyme
Naratriptan5-hydroxytryptamine receptor 1Dtarget
Naratriptan5-hydroxytryptamine receptor 1Btarget
Naratriptan5-hydroxytryptamine receptor 1Ftarget
Naratriptan5-hydroxytryptamine receptor 1Atarget
NaratriptanAmine oxidase [flavin-containing] Aenzyme
Rizatriptan5-hydroxytryptamine receptor 1Dtarget
Rizatriptan5-hydroxytryptamine receptor 1Btarget
Rizatriptan5-hydroxytryptamine receptor 1Ftarget
RizatriptanAmine oxidase [flavin-containing] Aenzyme
RizatriptanCytochrome P450 2D6enzyme
Rizatriptan5-hydroxytryptamine receptor 1Atarget
Rizatriptan5-hydroxytryptamine receptor 1Etarget
Rizatriptan5-hydroxytryptamine receptor 7target
Frovatriptan5-hydroxytryptamine receptor 1Dtarget
Frovatriptan5-hydroxytryptamine receptor 1Btarget
FrovatriptanCytochrome P450 1A2enzyme
Dimethyltryptamine5-hydroxytryptamine receptor 6target
Dimethyltryptamine5-hydroxytryptamine receptor 2Atarget
DimethyltryptamineSigma non-opioid intracellular receptor 1target
N-acetylserotoninSepiapterin reductasetarget
N-acetylhistamineGlutaminyl-peptide cyclotransferasetarget
ProtokylolBeta-2 adrenergic receptortarget
TryptamineAralkylamine dehydrogenase light chaintarget
TryptamineAralkylamine dehydrogenase heavy chaintarget
N-CaffeoyltyraminePeptide deformylasetarget
SerotoninSolute carrier family 22 member 2transporter
SerotoninSodium-dependent serotonin transportertarget
Serotonin5-hydroxytryptamine receptor 2Atarget
Serotonin5-hydroxytryptamine receptor 3Atarget
Serotonin5-hydroxytryptamine receptor 3Btarget
SerotoninSynaptic vesicular amine transportertarget
SynephrineAlpha-1 adrenergic receptorstarget
RacepinephrineAlpha-1A adrenergic receptortarget
RacepinephrineAlpha-1B adrenergic receptortarget
RacepinephrineAlpha-2A adrenergic receptortarget
RacepinephrineAlpha-2B adrenergic receptortarget
RacepinephrineAlpha-2C adrenergic receptortarget
RacepinephrineBeta-1 adrenergic receptortarget
RacepinephrineBeta-2 adrenergic receptortarget
RacepinephrineAlpha-1D adrenergic receptortarget
RacepinephrineBeta-3 adrenergic receptortarget
5-methoxy-N,N-dimethyltryptamine5-hydroxytryptamine receptor 1Atarget
5-methoxy-N,N-dimethyltryptamine5-hydroxytryptamine receptor 2Atarget
5-methoxy-N,N-dimethyltryptamineCytochrome P450 2D6enzyme