Phosphodiesterase 5 Inhibitors

Accession Number

DBCAT000518

Description

Compounds that specifically inhibit PHOSPHODIESTERASE 5.

Drugs

Drug	Drug Description
Sildenafil	A phosphodiesterase inhibitor used for the treatment of erectile dysfunction.
Tadalafil	A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.
Vardenafil	A phosphodiesterase 5 inhibitor used to treat erectile dysfunction.
Udenafil	A PDE5 inhibitor used to treat erectile dysfunction.
Mirodenafil	Mirodenafil has been used in trials studying the treatment and supportive care of Kidney Diseases, Urologic Diseases, Renal Insufficiency, Erectile Dysfunction, and Male Erectile Dysfunction.
Avanafil	A phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction.
Dipyridamole	A phosphodiesterase inhibitor used to prevent postoperative thromboembolic events.
Pentoxifylline	A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs.
Theophylline	A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction.
Fostamatinib	A spleen tyrosine kinase inhibitor used to treat chronic immune thrombocytopenia after attempting one other treatment.
Ibudilast	For the treatment of multiple sclerosis, asthma, and cerebrovascular disease.
Doxofylline	A methylxanthine derivative used in chronic obstructive pulmonary disease, asthma, and bronchospasms.

Drugs & Drug Targets

Drug	Target	Type
Sildenafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Sildenafil	Cytochrome P450 2C9	enzyme
Sildenafil	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
Sildenafil	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
Sildenafil	Cytochrome P450 3A4	enzyme
Sildenafil	Cytochrome P450 3A5	enzyme
Sildenafil	Cytochrome P450 3A7	enzyme
Sildenafil	Multidrug resistance-associated protein 4	transporter
Sildenafil	Multidrug resistance-associated protein 5	transporter
Sildenafil	Multidrug resistance-associated protein 7	transporter
Sildenafil	Cytochrome P450 2C19	enzyme
Sildenafil	Cytochrome P450 2D6	enzyme
Sildenafil	Cytochrome P450 2E1	enzyme
Sildenafil	Solute carrier organic anion transporter family member 1B1	transporter
Sildenafil	P-glycoprotein 1	transporter
Sildenafil	Ornithine decarboxylase	target
Sildenafil	Programmed cell death 1 ligand 1	target
Tadalafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Tadalafil	Cytochrome P450 3A4	enzyme
Tadalafil	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	target
Tadalafil	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
Vardenafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Vardenafil	Cytochrome P450 3A4	enzyme
Vardenafil	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
Vardenafil	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
Vardenafil	Cytochrome P450 3A5	enzyme
Vardenafil	P-glycoprotein 1	transporter
Vardenafil	Cytochrome P450 2C9	enzyme
Vardenafil	Cytochrome P450 2C8	enzyme
Vardenafil	Cytochrome P450 2C19	enzyme
Vardenafil	Cytochrome P450 2D6	enzyme
Udenafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Udenafil	Cytochrome P450 3A4	enzyme
Udenafil	Cytochrome P450 3A5	enzyme
Mirodenafil	Cytochrome P450 3A Subfamily	enzyme
Avanafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Avanafil	Cytochrome P450 3A4	enzyme
Avanafil	Serum albumin	carrier
Avanafil	Alpha-1-acid glycoprotein 1	carrier
Avanafil	P-glycoprotein 1	transporter
Avanafil	ATP-binding cassette sub-family G member 2	transporter
Avanafil	Cytochrome P450 2C9	enzyme
Dipyridamole	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	target
Dipyridamole	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Dipyridamole	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	target
Dipyridamole	Adenosine deaminase	target
Dipyridamole	Multidrug resistance-associated protein 4	transporter
Dipyridamole	Multidrug resistance-associated protein 5	transporter
Dipyridamole	P-glycoprotein 1	transporter
Dipyridamole	Calcipressin-1	target
Dipyridamole	Alpha-1-acid glycoprotein 1	target
Dipyridamole	Solute carrier organic anion transporter family member 1B1	transporter
Dipyridamole	Solute carrier organic anion transporter family member 1B3	transporter
Dipyridamole	Solute carrier organic anion transporter family member 2B1	transporter
Dipyridamole	Bile salt export pump	transporter
Pentoxifylline	5'-nucleotidase	target
Pentoxifylline	Adenosine receptor A1	target
Pentoxifylline	Adenosine receptor A2a	target
Pentoxifylline	Cytochrome P450 1A2	enzyme
Pentoxifylline	Phosphodiesterase enzymes	target
Theophylline	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	target
Theophylline	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	target
Theophylline	Adenosine receptor A2b	target
Theophylline	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	target
Theophylline	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Theophylline	Adenosine receptor A1	target
Theophylline	Adenosine receptor A2a	target
Theophylline	Cytochrome P450 1A2	enzyme
Theophylline	Adenosine deaminase	enzyme
Theophylline	Cytochrome P450 2E1	enzyme
Theophylline	Cytochrome P450 3A4	enzyme
Theophylline	Solute carrier family 22 member 7	transporter
Theophylline	Cytochrome P450 1A1	enzyme
Theophylline	Cytochrome P450 1B1	enzyme
Theophylline	Cytochrome P450 2D6	enzyme
Theophylline	Histone deacetylase 2	target
Theophylline	Copine-1	target
Theophylline	Minor histocompatibility antigen H13	target
Theophylline	Nodal modulator 1	target
Theophylline	Poly [ADP-ribose] polymerase 1	target
Theophylline	Protein RIC-3	target
Theophylline	Tubulin monoglycylase TTLL3	target
Fostamatinib	Adenosine receptor A3	target
Fostamatinib	Synaptic vesicular amine transporter	target
Fostamatinib	Fatty-acid amide hydrolase 1	target
Fostamatinib	Equilibrative nucleoside transporter 1	target
Fostamatinib	UDP-glucuronosyltransferase 1-1	target
Fostamatinib	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Fostamatinib	Arachidonate 5-lipoxygenase	target
Fostamatinib	Cathepsin S	target
Fostamatinib	Cathepsin L1	target
Fostamatinib	Tyrosine-protein kinase ABL1	target
Fostamatinib	Calcium-dependent protein kinase 1	target
Fostamatinib	Serine/threonine-protein kinase PknB	target
Fostamatinib	Ribosomal protein S6 kinase alpha-6	target
Fostamatinib	Non-receptor tyrosine-protein kinase TYK2	target
Fostamatinib	Atypical kinase COQ8A, mitochondrial	target
Fostamatinib	Tyrosine-protein kinase JAK1	target
Fostamatinib	Hepatocyte growth factor receptor	target
Fostamatinib	Serine/threonine-protein kinase NIM1	target
Fostamatinib	Serine/threonine-protein kinase MST4	target
Fostamatinib	cAMP-dependent protein kinase catalytic subunit alpha	target
Fostamatinib	Serine/threonine-protein kinase 24	target
Fostamatinib	Serine/threonine-protein kinase 3	target
Fostamatinib	Tyrosine-protein kinase Tec	target
Fostamatinib	Tyrosine-protein kinase SYK	target
Fostamatinib	Serine/threonine-protein kinase 33	target
Fostamatinib	Serine/threonine-protein kinase 35	target
Fostamatinib	Serine/threonine-protein kinase 36	target
Fostamatinib	Serine/threonine-protein kinase 38	target
Fostamatinib	Serine/threonine-protein kinase 38-like	target
Fostamatinib	STE20/SPS1-related proline-alanine-rich protein kinase	target
Fostamatinib	Serine/threonine-protein kinase TAO1	target
Fostamatinib	Serine/threonine-protein kinase TAO2	target
Fostamatinib	Serine/threonine-protein kinase TAO3	target
Fostamatinib	Serine/threonine-protein kinase TBK1	target
Fostamatinib	Angiopoietin-1 receptor	target
Fostamatinib	Dual specificity testis-specific protein kinase 1	target
Fostamatinib	TGF-beta receptor type-1	target
Fostamatinib	TGF-beta receptor type-2	target
Fostamatinib	Tyrosine-protein kinase receptor Tie-1	target
Fostamatinib	Serine/threonine-protein kinase tousled-like 1	target
Fostamatinib	Serine/threonine-protein kinase tousled-like 2	target
Fostamatinib	TRAF2 and NCK-interacting protein kinase	target
Fostamatinib	Non-receptor tyrosine-protein kinase TNK1	target
Fostamatinib	Activated CDC42 kinase 1	target
Fostamatinib	Serine/threonine-protein kinase TNNI3K	target
Fostamatinib	Testis-specific serine/threonine-protein kinase 1	target
Fostamatinib	Dual specificity protein kinase TTK	target
Fostamatinib	Tyrosine-protein kinase TXK	target
Fostamatinib	Tyrosine-protein kinase receptor TYRO3	target
Fostamatinib	Serine/threonine-protein kinase ULK1	target
Fostamatinib	Serine/threonine-protein kinase ULK2	target
Fostamatinib	Serine/threonine-protein kinase ULK3	target
Fostamatinib	Wee1-like protein kinase	target
Fostamatinib	Tyrosine-protein kinase Yes	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 19	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase MLT	target
Fostamatinib	Tyrosine-protein kinase ZAP-70	target
Fostamatinib	AP2-associated protein kinase 1	target
Fostamatinib	Tyrosine-protein kinase ABL2	target
Fostamatinib	Activin receptor type-1	target
Fostamatinib	Activin receptor type-1B	target
Fostamatinib	Atypical kinase COQ8B, mitochondrial	target
Fostamatinib	ALK tyrosine kinase receptor	target
Fostamatinib	Ankyrin repeat and protein kinase domain-containing protein 1	target
Fostamatinib	Aurora kinase A	target
Fostamatinib	Aurora kinase B	target
Fostamatinib	Aurora kinase C	target
Fostamatinib	Tyrosine-protein kinase receptor UFO	target
Fostamatinib	Tyrosine-protein kinase Blk	target
Fostamatinib	BMP-2-inducible protein kinase	target
Fostamatinib	Bone morphogenetic protein receptor type-1B	target
Fostamatinib	Bone morphogenetic protein receptor type-2	target
Fostamatinib	Cytoplasmic tyrosine-protein kinase BMX	target
Fostamatinib	Serine/threonine-protein kinase B-raf	target
Fostamatinib	Tyrosine-protein kinase BTK	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type 1	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type 1D	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type 1G	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit alpha	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit beta	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit delta	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit gamma	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase kinase 1	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase kinase 2	target
Fostamatinib	Peripheral plasma membrane protein CASK	target
Fostamatinib	Kappa-casein	target
Fostamatinib	Cyclin-dependent kinase 1	target
Fostamatinib	Serine/threonine-protein kinase MRCK gamma	target
Fostamatinib	Cyclin-dependent kinase 4	target
Fostamatinib	Cyclin-dependent kinase-like 1	target
Fostamatinib	Cyclin-dependent kinase-like 2	target
Fostamatinib	Serine/threonine-protein kinase Chk1	target
Fostamatinib	Serine/threonine-protein kinase Chk2	target
Fostamatinib	Citron Rho-interacting kinase	target
Fostamatinib	Dual specificity protein kinase CLK1	target
Fostamatinib	Dual specificity protein kinase CLK2	target
Fostamatinib	Dual specificity protein kinase CLK3	target
Fostamatinib	Dual specificity protein kinase CLK4	target
Fostamatinib	Macrophage colony-stimulating factor 1 receptor	target
Fostamatinib	Tyrosine-protein kinase CSK	target
Fostamatinib	Casein kinase I isoform alpha	target
Fostamatinib	Casein kinase II subunit alpha	target
Fostamatinib	Casein kinase II subunit alpha'	target
Fostamatinib	Death-associated protein kinase 1	target
Fostamatinib	Death-associated protein kinase 2	target
Fostamatinib	Death-associated protein kinase 3	target
Fostamatinib	Serine/threonine-protein kinase DCLK1	target
Fostamatinib	Serine/threonine-protein kinase DCLK2	target
Fostamatinib	Serine/threonine-protein kinase DCLK3	target
Fostamatinib	Epithelial discoidin domain-containing receptor 1	target
Fostamatinib	Discoidin domain-containing receptor 2	target
Fostamatinib	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	target
Fostamatinib	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	target
Fostamatinib	Epidermal growth factor receptor	target
Fostamatinib	Eukaryotic translation initiation factor 2-alpha kinase 1	target
Fostamatinib	Interferon-induced, double-stranded RNA-activated protein kinase	target
Fostamatinib	eIF-2-alpha kinase GCN2	target
Fostamatinib	Ephrin type-A receptor 1	target
Fostamatinib	Ephrin type-A receptor 2	target
Fostamatinib	Ephrin type-A receptor 3	target
Fostamatinib	Ephrin type-A receptor 4	target
Fostamatinib	Ephrin type-A receptor 5	target
Fostamatinib	Ephrin type-A receptor 6	target
Fostamatinib	Ephrin type-A receptor 7	target
Fostamatinib	Ephrin type-A receptor 8	target
Fostamatinib	Ephrin type-B receptor 1	target
Fostamatinib	Ephrin type-B receptor 2	target
Fostamatinib	Ephrin type-B receptor 4	target
Fostamatinib	Ephrin type-B receptor 6	target
Fostamatinib	Receptor tyrosine-protein kinase erbB-2	target
Fostamatinib	Receptor tyrosine-protein kinase erbB-4	target
Fostamatinib	Serine/threonine-protein kinase/endoribonuclease IRE1	target
Fostamatinib	Tyrosine-protein kinase Fer	target
Fostamatinib	Tyrosine-protein kinase Fes/Fps	target
Fostamatinib	Fibroblast growth factor receptor 1	target
Fostamatinib	Fibroblast growth factor receptor 2	target
Fostamatinib	Fibroblast growth factor receptor 3	target
Fostamatinib	Tyrosine-protein kinase Fgr	target
Fostamatinib	Vascular endothelial growth factor receptor 1	target
Fostamatinib	Receptor-type tyrosine-protein kinase FLT3	target
Fostamatinib	Vascular endothelial growth factor receptor 3	target
Fostamatinib	Serine/threonine-protein kinase mTOR	target
Fostamatinib	Tyrosine-protein kinase FRK	target
Fostamatinib	Tyrosine-protein kinase Fyn	target
Fostamatinib	Cyclin-G-associated kinase	target
Fostamatinib	Glycogen synthase kinase-3 alpha	target
Fostamatinib	Glycogen synthase kinase-3 beta	target
Fostamatinib	Tyrosine-protein kinase HCK	target
Fostamatinib	Homeodomain-interacting protein kinase 2	target
Fostamatinib	Homeodomain-interacting protein kinase 3	target
Fostamatinib	Serine/threonine-protein kinase ICK	target
Fostamatinib	Inhibitor of nuclear factor kappa-B kinase subunit beta	target
Fostamatinib	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	target
Fostamatinib	Insulin receptor	target
Fostamatinib	Insulin receptor-related protein	target
Fostamatinib	Interleukin-1 receptor-associated kinase 1	target
Fostamatinib	Interleukin-1 receptor-associated kinase 3	target
Fostamatinib	Interleukin-1 receptor-associated kinase 4	target
Fostamatinib	Tyrosine-protein kinase ITK/TSK	target
Fostamatinib	Tyrosine-protein kinase JAK2	target
Fostamatinib	Tyrosine-protein kinase JAK3	target
Fostamatinib	Vascular endothelial growth factor receptor 2	target
Fostamatinib	Serine/threonine-protein kinase SIK3	target
Fostamatinib	Mast/stem cell growth factor receptor Kit	target
Fostamatinib	Serine/threonine-protein kinase LATS1	target
Fostamatinib	Tyrosine-protein kinase Lck	target
Fostamatinib	LIM domain kinase 1	target
Fostamatinib	LIM domain kinase 2	target
Fostamatinib	Leucine-rich repeat serine/threonine-protein kinase 2	target
Fostamatinib	Leukocyte tyrosine kinase receptor	target
Fostamatinib	Tyrosine-protein kinase Lyn	target
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 2	target
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 3	target
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 5	target
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 6	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 1	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 10	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 11	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 12	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 13	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 15	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 2	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 3	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 4	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 6	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 9	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 1	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 2	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 3	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 4	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 5	target
Fostamatinib	Mitogen-activated protein kinase 10	target
Fostamatinib	Mitogen-activated protein kinase 13	target
Fostamatinib	Mitogen-activated protein kinase 14	target
Fostamatinib	Mitogen-activated protein kinase 15	target
Fostamatinib	Mitogen-activated protein kinase 4	target
Fostamatinib	Mitogen-activated protein kinase 7	target
Fostamatinib	Mitogen-activated protein kinase 9	target
Fostamatinib	MAP kinase-activated protein kinase 5	target
Fostamatinib	Serine/threonine-protein kinase MARK1	target
Fostamatinib	Serine/threonine-protein kinase MARK2	target
Fostamatinib	MAP/microtubule affinity-regulating kinase 3	target
Fostamatinib	MAP/microtubule affinity-regulating kinase 4	target
Fostamatinib	CLIP-associating protein 1	target
Fostamatinib	Microtubule-associated serine/threonine-protein kinase 1	target
Fostamatinib	Megakaryocyte-associated tyrosine-protein kinase	target
Fostamatinib	Maternal embryonic leucine zipper kinase	target
Fostamatinib	Tyrosine-protein kinase Mer	target
Fostamatinib	Misshapen-like kinase 1	target
Fostamatinib	MAP kinase-interacting serine/threonine-protein kinase 1	target
Fostamatinib	MAP kinase-interacting serine/threonine-protein kinase 2	target
Fostamatinib	Macrophage-stimulating protein receptor	target
Fostamatinib	Muscle, skeletal receptor tyrosine-protein kinase	target
Fostamatinib	Myosin light chain kinase, smooth muscle	target
Fostamatinib	Myosin light chain kinase 2, skeletal/cardiac muscle	target
Fostamatinib	Myosin light chain kinase 3	target
Fostamatinib	Myosin light chain kinase family member 4	target
Fostamatinib	Myosin-IIIa	target
Fostamatinib	Serine/threonine-protein kinase Nek1	target
Fostamatinib	Serine/threonine-protein kinase Nek11	target
Fostamatinib	Serine/threonine-protein kinase Nek2	target
Fostamatinib	Serine/threonine-protein kinase Nek3	target
Fostamatinib	Serine/threonine-protein kinase Nek4	target
Fostamatinib	Serine/threonine-protein kinase Nek5	target
Fostamatinib	Serine/threonine-protein kinase Nek9	target
Fostamatinib	High affinity nerve growth factor receptor	target
Fostamatinib	BDNF/NT-3 growth factors receptor	target
Fostamatinib	NT-3 growth factor receptor	target
Fostamatinib	NUAK family SNF1-like kinase 1	target
Fostamatinib	NUAK family SNF1-like kinase 2	target
Fostamatinib	Serine/threonine-protein kinase OSR1	target
Fostamatinib	Serine/threonine-protein kinase PAK 1	target
Fostamatinib	Serine/threonine-protein kinase PAK 2	target
Fostamatinib	Serine/threonine-protein kinase PAK 3	target
Fostamatinib	Serine/threonine-protein kinase PAK 4	target
Fostamatinib	Serine/threonine-protein kinase PAK 6	target
Fostamatinib	Serine/threonine-protein kinase PAK 5	target
Fostamatinib	Cyclin-dependent kinase 16	target
Fostamatinib	Cyclin-dependent kinase 17	target
Fostamatinib	Platelet-derived growth factor receptor alpha	target
Fostamatinib	Platelet-derived growth factor receptor beta	target
Fostamatinib	3-phosphoinositide-dependent protein kinase 1	target
Fostamatinib	Cyclin-dependent kinase 15	target
Fostamatinib	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	target
Fostamatinib	Phosphatidylinositol 4-kinase beta	target
Fostamatinib	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	target
Fostamatinib	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	target
Fostamatinib	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	target
Fostamatinib	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	target
Fostamatinib	Serine/threonine-protein kinase pim-1	target
Fostamatinib	Serine/threonine-protein kinase pim-3	target
Fostamatinib	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	target
Fostamatinib	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	target
Fostamatinib	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	target
Fostamatinib	Serine/threonine-protein kinase N1	target
Fostamatinib	Serine/threonine-protein kinase N2	target
Fostamatinib	Serine/threonine-protein kinase PLK1	target
Fostamatinib	Serine/threonine-protein kinase PLK2	target
Fostamatinib	Serine/threonine-protein kinase PLK3	target
Fostamatinib	Serine/threonine-protein kinase PLK4	target
Fostamatinib	5'-AMP-activated protein kinase catalytic subunit alpha-1	target
Fostamatinib	5'-AMP-activated protein kinase	target
Fostamatinib	cAMP-dependent protein kinase catalytic subunit beta	target
Fostamatinib	Protein kinase C delta type	target
Fostamatinib	Protein kinase C epsilon type	target
Fostamatinib	Protein kinase C gamma type (PRKCG)	target
Fostamatinib	Protein kinase C iota type	target
Fostamatinib	Protein kinase C theta type	target
Fostamatinib	Serine/threonine-protein kinase D1	target
Fostamatinib	cGMP-dependent protein kinase 2	target
Fostamatinib	Serine/threonine-protein kinase PRP4 homolog	target
Fostamatinib	Focal adhesion kinase 1	target
Fostamatinib	Protein-tyrosine kinase 2-beta	target
Fostamatinib	Protein-tyrosine kinase 6	target
Fostamatinib	RAF proto-oncogene serine/threonine-protein kinase	target
Fostamatinib	Proto-oncogene tyrosine-protein kinase receptor Ret	target
Fostamatinib	Serine/threonine-protein kinase RIO1	target
Fostamatinib	Serine/threonine-protein kinase RIO2	target
Fostamatinib	Serine/threonine-protein kinase RIO3	target
Fostamatinib	Receptor-interacting serine/threonine-protein kinase 1	target
Fostamatinib	Receptor-interacting serine/threonine-protein kinase 2	target
Fostamatinib	Receptor-interacting serine/threonine-protein kinase 4	target
Fostamatinib	Rho-associated protein kinase 2	target
Fostamatinib	Proto-oncogene tyrosine-protein kinase ROS	target
Fostamatinib	Ribosomal protein S6 kinase alpha-1	target
Fostamatinib	Ribosomal protein S6 kinase alpha-3	target
Fostamatinib	Serine/threonine-protein kinase SBK1	target
Fostamatinib	Uncharacterized serine/threonine-protein kinase SBK3	target
Fostamatinib	Serine/threonine-protein kinase Sgk3	target
Fostamatinib	Serine/threonine-protein kinase SIK1	target
Fostamatinib	Serine/threonine-protein kinase SIK2	target
Fostamatinib	STE20-like serine/threonine-protein kinase	target
Fostamatinib	SNF-related serine/threonine-protein kinase	target
Fostamatinib	Proto-oncogene tyrosine-protein kinase Src	target
Fostamatinib	Tyrosine-protein kinase Srms	target
Fostamatinib	Serine/threonine-protein kinase 10	target
Fostamatinib	Serine/threonine-protein kinase 16	target
Fostamatinib	Serine/threonine-protein kinase 17A	target
Fostamatinib	Serine/threonine-protein kinase 17B	target
Fostamatinib	Serine/threonine-protein kinase 32A	target
Fostamatinib	Cytochrome P450 3A4	enzyme
Fostamatinib	ATP-binding cassette sub-family G member 2	transporter
Fostamatinib	ATP-binding cassette sub-family B member 5	transporter
Fostamatinib	UDP-glucuronosyltransferase 1-9	enzyme
Ibudilast	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	target
Ibudilast	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	target
Ibudilast	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	target
Ibudilast	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	target
Ibudilast	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	target
Doxofylline	Adenosine receptor A2a	target
Doxofylline	Beta-2 adrenergic receptor	target
Doxofylline	Cytochrome P450 1A2	enzyme
Doxofylline	cGMP-dependent 3',5'-cyclic phosphodiesterase	target