Indole Alkaloids

Name
Indole Alkaloids
Accession Number
DBCAT000527
Description

Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)

Drugs
DrugDrug Description
PhysostigmineA cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity.
Rauwolfia serpentina rootRauwolfia alkaloids are indicated in the treatment of hypertension . Rauwolfia alkaloids have been used for relief of symptoms in agitated psychotic states such as schizophrenia; however, use as antipsychotics...
AjmalineAn antiarrhythmic used to manage a variety of forms of tachycardias.
StaurosporineAn indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
MetoserpateNot Annotated
PsilocybinPsilocybin has been investigated for the treatment of Anxiety and Stage IV Melanoma. In November, 2019, it was granted Breakthrough Therapy status by the FDA.
RaubasineNot Annotated
ReserpineFor the treatment of hypertension
VindesineA vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL).
VinorelbineA vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC.
VincristineA vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis.
VinblastineA vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
TadalafilA phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.
AlosetronA 5-HT3 antagonist used to treat diarrhea-predominant IBS.
DeserpidineAn alkaloid that has been used to manage hypertension.
RescinnamineFor the treatment of hypertension.
YohimbineAn alpha-2-adrenergic blocker and sympatholytic found in supplements used to.
AlmitrineFor the treatment of chronic obstructive pulmonary disease.
7-HydroxystaurosporineNot Available
DeacetoxyvinzolidineNot Available
VoacamineFor the treatment of malaria. Also under investigation for the modulation of multidrug resistance in cancer cells.
PhenserineFor the treatment of Alzheimer's disease (AD).
VintafolideInvestigated for use/treatment in solid tumors.
MidostaurinAn antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL).
HarmineNot Available
MetralindoleInvestigated for the treatment of depression.
VinflunineA vinca alkaloid used to treat advanced or metastatic transitional cell carcinoma of the urothelial tract after a platinum containing treatment has failed.
OrantinibOrantinib has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Kidney Cancer, Gastric Cancer, and Prostate Cancer, among others.
VinpocetineA synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease.
LurbinectedinA chemotherapeutic DNA alkylating agent used in the treatment of metastatic small-cell lung cancer.
TAK-901TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others.
VincamineVincamine is a monoterpenoid indole alkaloid obtained from the leaves of Vinca minor with a vasodilatory property. Studies indicate that vincamine increases the regional cerebral blood flow.
TenidapNot Annotated
PrajmalineNot Annotated
BietaserpineNot Annotated
LorajmineNot Annotated
VinburnineNot Annotated
MebhydrolinAn antihistamine indicated in the treatment of allergies.
HarmalineNot Annotated
Flortaucipir F-18A small lipophilic tracer containing [18F]fluoride capable of crossing the blood-brain barrier and binding to aggregated tau protein; used in PET imaging for the diagnosis of Alzheimer's disease.
FlortaucipirFlortaucipir is under investigation in clinical trial NCT03507257 (Longitudinal Early-onset Alzheimer's Disease Study Protocol).
18-methoxycoronaridine18-methoxycoronaridine is under investigation in clinical trial NCT03084952 (Phase 2 Trial to Evaluate 18-Methoxycoronaridine Efficacy, Safety and Tolerability in Cutaneous Leishmaniasis Patients).
PosiphenPosiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease).
StrychnineNot Annotated
EllipticineEllipticine is a potent antineoplastic agent.
ZK-93423ZK-93423 is a beta-carboline with muscle relaxant activity with agonistic properties at the benzodiazepine receptor.
Drugs & Drug Targets
DrugTargetType
PhysostigmineAcetylcholinesterasetarget
PhysostigmineNeuronal acetylcholine receptor subunit alpha-4target
PhysostigmineNeuronal acetylcholine receptor subunit beta-2target
Rauwolfia serpentina rootSynaptic vesicular amine transportertarget
Rauwolfia serpentina rootMonoamine oxidaseenzyme
Rauwolfia serpentina rootSodium-dependent noradrenaline transportertransporter
Rauwolfia serpentina rootSynaptic vesicular amine transportertransporter
AjmalineAlpha-1-acid glycoprotein 1carrier
AjmalineSodium channel protein type 5 subunit alphatarget
StaurosporineTyrosine-protein kinase Lcktarget
StaurosporineSerine/threonine-protein kinase pim-1target
StaurosporineTyrosine-protein kinase ITK/TSKtarget
StaurosporineTyrosine-protein kinase SYKtarget
StaurosporineMAP kinase-activated protein kinase 2target
StaurosporineGlycogen synthase kinase-3 betatarget
StaurosporineTyrosine-protein kinase CSKtarget
StaurosporineCyclin-dependent kinase 2target
StaurosporinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
Staurosporine3-phosphoinositide-dependent protein kinase 1target
StaurosporineProtein kinase C theta typetarget
StaurosporineTyrosine-protein kinase ZAP-70target
StaurosporineP-glycoprotein 1transporter
StaurosporineMuscarinic acetylcholine receptor M1target
StaurosporineProtein kinase Ctarget
ReserpineSynaptic vesicular amine transportertarget
ReserpineP-glycoprotein 1transporter
ReserpineSolute carrier family 22 member 1transporter
ReserpineBile salt export pumptransporter
ReserpineCanalicular multispecific organic anion transporter 1transporter
ReserpineSolute carrier family 22 member 2transporter
ReserpineCytochrome P450 3A5enzyme
ReserpineChromaffin granule amine transportertarget
ReserpineBaculoviral IAP repeat-containing protein 5target
ReserpineSolute carrier organic anion transporter family member 1B1transporter
ReserpineSolute carrier organic anion transporter family member 2B1transporter
VindesineTubulin beta-1 chaintarget
VindesineCytochrome P450 3A4enzyme
VinorelbineTubulin beta chaintarget
VinorelbineCytochrome P450 3A4enzyme
VinorelbineCytochrome P450 2D6enzyme
VincristineTubulin beta chaintarget
VincristineCytochrome P450 3A4enzyme
VincristineCytochrome P450 3A5enzyme
VincristineCytochrome P450 3A7enzyme
VincristineP-glycoprotein 1transporter
VincristineCanalicular multispecific organic anion transporter 2transporter
VincristineSolute carrier family 22 member 3transporter
VincristineMultidrug resistance-associated protein 1transporter
VincristineMultidrug resistance-associated protein 7transporter
VincristineCanalicular multispecific organic anion transporter 1transporter
VincristineBile salt export pumptransporter
VincristineATP-binding cassette sub-family G member 2transporter
VincristineTubulin alpha-4A chaintarget
VincristineRalA-binding protein 1transporter
VincristineSolute carrier organic anion transporter family member 1B1transporter
VincristineSolute carrier organic anion transporter family member 1B3transporter
VinblastineTubulin beta chaintarget
VinblastineTranscription factor AP-1target
VinblastineCytochrome P450 3A4enzyme
VinblastineP-glycoprotein 1transporter
VinblastineMultidrug resistance-associated protein 1transporter
VinblastineCanalicular multispecific organic anion transporter 1transporter
VinblastineMultidrug resistance-associated protein 6transporter
VinblastineBile salt export pumptransporter
VinblastineTubulin alpha-1A chaintarget
VinblastineTubulin delta chaintarget
VinblastineTubulin epsilon chaintarget
VinblastineTubulin gamma-1 chaintarget
VinblastineCytochrome P450 2D6enzyme
VinblastineSolute carrier organic anion transporter family member 1B1transporter
TadalafilcGMP-specific 3',5'-cyclic phosphodiesterasetarget
TadalafilCytochrome P450 3A4enzyme
TadalafilDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11Atarget
TadalafilRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget
Alosetron5-hydroxytryptamine receptor 3Atarget
AlosetronCytochrome P450 1A2enzyme
AlosetronCytochrome P450 2C9enzyme
AlosetronCytochrome P450 3A4enzyme
AlosetronCytochrome P450 2E1enzyme
DeserpidineSynaptic vesicular amine transportertarget
RescinnamineAngiotensin-converting enzymetarget
YohimbineAlpha-2A adrenergic receptortarget
YohimbineAlpha-2B adrenergic receptortarget
YohimbineAlpha-2C adrenergic receptortarget
Yohimbine5-hydroxytryptamine receptor 1Atarget
Yohimbine5-hydroxytryptamine receptor 1Btarget
Yohimbine5-hydroxytryptamine receptor 1Dtarget
YohimbineDopamine D2 receptortarget
YohimbineDopamine D3 receptortarget
Yohimbine5-hydroxytryptamine receptor 2Atarget
Yohimbine5-hydroxytryptamine receptor 2Ctarget
YohimbineCytochrome P450 2D6enzyme
YohimbineCytochrome P450 3A4enzyme
YohimbineATP-sensitive potassium channeltarget
Yohimbine5-hydroxytryptamine receptor 2Btarget
AlmitrineSodium/potassium-transporting ATPase subunit alpha-1target
7-Hydroxystaurosporine3-phosphoinositide-dependent protein kinase 1target
DeacetoxyvinzolidineCalmodulintarget
VoacamineP-glycoprotein 1target
VoacamineP-glycoprotein 1transporter
PhenserineAcetylcholinesterasetarget
PhenserineCholinesterasetarget
PhenserineAmyloid beta A4 proteintarget
VintafolideFolate receptor betatarget
VintafolideFolate receptor gammatarget
VintafolideFolate receptor alphatarget
MidostaurinProtein kinase C alpha typetarget
MidostaurinVascular endothelial growth factor receptor 2target
MidostaurinMast/stem cell growth factor receptor Kittarget
MidostaurinPlatelet-derived growth factor receptor alphatarget
MidostaurinPlatelet-derived growth factor receptor betatarget
MidostaurinReceptor-type tyrosine-protein kinase FLT3target
MidostaurinCytochrome P450 3A Subfamilyenzyme
MidostaurinCytochrome P450 1A2enzyme
MidostaurinCytochrome P450 2B6enzyme
MidostaurinCytochrome P450 2C8enzyme
MidostaurinCytochrome P450 2C9enzyme
MidostaurinCytochrome P450 2C19enzyme
MidostaurinCytochrome P450 2D6enzyme
MidostaurinCytochrome P450 2E1enzyme
MidostaurinCytochrome P450 3A4enzyme
MidostaurinCytochrome P450 3A5enzyme
MidostaurinCytochrome P450 3A7enzyme
MidostaurinCytochrome P450 3A43enzyme
HarmineAmine oxidase [flavin-containing] Atarget
VinflunineATP-binding cassette sub-family B member 5transporter
VinflunineP-glycoprotein 1transporter
VinflunineSerum albumincarrier
Vinfluninealpha1-acid glycoproteincarrier
VinflunineCytochrome P450 3A4enzyme
VinflunineTubulin beta chaintarget
VinpocetineCytochrome P450 3A4enzyme
LurbinectedinCytochrome P450 3A4enzyme
LurbinectedinDNAtarget
LurbinectedinSerum albumincarrier
LurbinectedinAlpha-1-acid glycoprotein 1carrier
LurbinectedinP-glycoprotein 1transporter
LurbinectedinSolute carrier organic anion transporter family member 1B1transporter
LurbinectedinSolute carrier organic anion transporter family member 1B3transporter
LurbinectedinSolute carrier family 22 member 1transporter
TAK-901Aurora kinase Btarget
TAK-901Apoptosis regulator BAXtarget
HarmalineHistamine N-methyltransferasetarget
Flortaucipir F-18Microtubule-associated protein tautarget
Flortaucipir F-18Amine oxidase [flavin-containing] Atarget
Flortaucipir F-18Amine oxidase [flavin-containing] Btarget