Ergot Alkaloids and Derivatives

Name
Ergot Alkaloids and Derivatives
Accession Number
DBCAT000606  (DBCAT002711)
Description

Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Many of the ergot alkaloids act as alpha-adrenergic antagonists.

ATC Classification
Drugs
DrugDrug Description
MethysergideAn ergot alkaloid used for the prophylaxis of migraine and cluster headaches.
DihydroergotamineAn ergot alkaloid used in the acute treatment of migraine headache and cluster headache.
LisurideFor the management of Parkinson's Disease
ErgotamineAn alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches.
NicergolineAn ergot derivative use for the treatment of symptoms associated with cerebrovascular abnormalities.
Ergoloid mesylateA nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity.
ErgometrineAn ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony.
DihydroergocristineAn ergot alkaloid used to delay progressive mental decline in conditions like Alzheimer's.
MethylergometrineAn ergot alkaloid used to prevent and control uterine atony and hemorrhage before and after delivery.
CabergolineA dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes.
PergolideA long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy.
BromocriptineA dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome.
Lysergic acid diethylamideDebate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by...
DihydroergocornineA nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity.
DihydroergocryptineA dopamine agonist indicated in the treatment of cerebrovascular diseases and atherosclerosis.
TergurideNot Annotated
MetergolineAn ergot-derivative that acts as an antagonist at certain 5-HT receptor subtypes and as an agonist at dopamine receptors. It is often used in situations where inhibition of prolactin is desirable.
DihydroergotoxineNot Annotated
Drugs & Drug Targets
DrugTargetType
Methysergide5-hydroxytryptamine receptor 2Atarget
Methysergide5-hydroxytryptamine receptor 1Atarget
Methysergide5-hydroxytryptamine receptor 7target
Methysergide5-hydroxytryptamine receptor 2Ctarget
Methysergide5-hydroxytryptamine receptor 2Btarget
Methysergide5-hydroxytryptamine receptor 1Btarget
Methysergide5-hydroxytryptamine receptor 1Ftarget
Methysergide5-hydroxytryptamine receptor 1Etarget
MethysergideCytochrome P450 3A4enzyme
Dihydroergotamine5-hydroxytryptamine receptor 1Dtarget
Dihydroergotamine5-hydroxytryptamine receptor 1Btarget
DihydroergotamineCytochrome P450 3A4enzyme
DihydroergotamineAlpha-2A adrenergic receptortarget
Dihydroergotamine5-hydroxytryptamine receptor 2Btarget
DihydroergotamineP-glycoprotein 1transporter
Dihydroergotamine5-hydroxytryptamine receptor 1Atarget
Dihydroergotamine5-hydroxytryptamine receptor 1Etarget
Dihydroergotamine5-hydroxytryptamine receptor 2Atarget
Dihydroergotamine5-hydroxytryptamine receptor 2Ctarget
DihydroergotamineAlpha-1 adrenergic receptorstarget
DihydroergotamineAlpha-2 adrenergic receptorstarget
DihydroergotamineDopamine D2 receptortarget
DihydroergotamineDopamine D3 receptortarget
DihydroergotamineDopamine D4 receptortarget
Dihydroergotamine5-hydroxytryptamine receptor 1Ftarget
Dihydroergotamine5-hydroxytryptamine receptor 4target
DihydroergotamineBeta-3 adrenergic receptortarget
LisurideDopamine D1 receptortarget
Lisuride5-hydroxytryptamine receptor 1Atarget
LisurideDopamine D2 receptortarget
LisurideAlpha-2A adrenergic receptortarget
LisurideAlpha-2B adrenergic receptortarget
LisurideAlpha-2C adrenergic receptortarget
LisurideDopamine D3 receptortarget
Lisuride5-hydroxytryptamine receptor 1Dtarget
Lisuride5-hydroxytryptamine receptor 2Btarget
Lisuride5-hydroxytryptamine receptor 2Atarget
LisurideDopamine D4 receptortarget
Lisuride5-hydroxytryptamine receptor 2Ctarget
LisurideDopamine D5 receptortarget
Lisuride5-hydroxytryptamine receptor 1Btarget
LisurideCytochrome P450 3A4enzyme
Lisuride5-hydroxytryptamine receptor 7target
ErgotamineAlpha-1A adrenergic receptortarget
Ergotamine5-hydroxytryptamine receptor 1Dtarget
Ergotamine5-hydroxytryptamine receptor 1Btarget
Ergotamine5-hydroxytryptamine receptor 2Atarget
ErgotamineAlpha-2A adrenergic receptortarget
ErgotamineDopamine D2 receptortarget
ErgotamineCytochrome P450 3A4enzyme
ErgotamineAlpha-1B adrenergic receptortarget
ErgotamineAlpha-1D adrenergic receptortarget
ErgotamineP-glycoprotein 1transporter
ErgotamineD(1) dopamine receptortarget
Ergotamine5-hydroxytryptamine receptor 1Atarget
Ergotamine5-hydroxytryptamine receptor 1Ftarget
Ergotamine5-hydroxytryptamine receptor 2Ctarget
Ergotamine5-hydroxytryptamine receptor 2Btarget
ErgotamineAlpha-2C adrenergic receptortarget
NicergolineAlpha-1A adrenergic receptortarget
NicergolineCytochrome P450 2D6enzyme
Ergoloid mesylateDopamine receptortarget
Ergoloid mesylateAlpha adrenergic receptortarget
Ergoloid mesylateBeta adrenergic receptortarget
Ergoloid mesylateSerotonin Receptorstarget
Ergoloid mesylateCytochrome P450 3A4enzyme
ErgometrineCytochrome P450 3A4enzyme
ErgometrineP-glycoprotein 1transporter
ErgometrineAlpha-1A adrenergic receptortarget
DihydroergocristineSerotonin Receptorstarget
DihydroergocristineBeta adrenergic receptortarget
DihydroergocristineAlpha adrenergic receptortarget
DihydroergocristineDopamine receptortarget
DihydroergocristineBile salt export pumptransporter
DihydroergocristineCytochrome P450 3A4enzyme
MethylergometrineDopamine D1 receptortarget
MethylergometrineCytochrome P450 3A4enzyme
Methylergometrine5-hydroxytryptamine receptor 2Btarget
CabergolineDopamine D2 receptortarget
Cabergoline5-hydroxytryptamine receptor 2Btarget
CabergolineDopamine D3 receptortarget
Cabergoline5-hydroxytryptamine receptor 2Atarget
CabergolineAlpha-2B adrenergic receptortarget
Cabergoline5-hydroxytryptamine receptor 1Dtarget
CabergolineDopamine D4 receptortarget
CabergolineAlpha-2A adrenergic receptortarget
Cabergoline5-hydroxytryptamine receptor 1Atarget
CabergolineAlpha-2C adrenergic receptortarget
CabergolineDopamine D5 receptortarget
CabergolineDopamine D1 receptortarget
Cabergoline5-hydroxytryptamine receptor 1Btarget
Cabergoline5-hydroxytryptamine receptor 2Ctarget
CabergolineCytochrome P450 3A4enzyme
Cabergoline5-hydroxytryptamine receptor 7target
CabergolineAlpha-1A adrenergic receptortarget
CabergolineAlpha-1B adrenergic receptortarget
CabergolineAlpha-1D adrenergic receptortarget
CabergolineBeta-1 adrenergic receptortarget
CabergolineBeta-2 adrenergic receptortarget
CabergolineD(1) dopamine receptortarget
CabergolineP-glycoprotein 1transporter
PergolideDopamine D2 receptortarget
PergolideDopamine D1 receptortarget
PergolideDopamine D3 receptortarget
Pergolide5-hydroxytryptamine receptor 1Atarget
PergolideAlpha-1A adrenergic receptortarget
PergolideAlpha-2 adrenergic receptorstarget
PergolideAlpha-1B adrenergic receptortarget
PergolideAlpha-1D adrenergic receptortarget
PergolideDopamine D4 receptortarget
PergolideDopamine D5 receptortarget
Pergolide5-hydroxytryptamine receptor 1Btarget
Pergolide5-hydroxytryptamine receptor 1Dtarget
Pergolide5-hydroxytryptamine receptor 2Atarget
Pergolide5-hydroxytryptamine receptor 2Btarget
Pergolide5-hydroxytryptamine receptor 2Ctarget
PergolideCytochrome P450 3A4enzyme
BromocriptineDopamine D2 receptortarget
BromocriptineCytochrome P450 3A4enzyme
Bromocriptine5-hydroxytryptamine receptor 1Dtarget
BromocriptineAlpha-2A adrenergic receptortarget
BromocriptineDopamine D3 receptortarget
Bromocriptine5-hydroxytryptamine receptor 1Atarget
BromocriptineAlpha-2C adrenergic receptortarget
BromocriptineAlpha-2B adrenergic receptortarget
Bromocriptine5-hydroxytryptamine receptor 2Btarget
BromocriptineDopamine D4 receptortarget
Bromocriptine5-hydroxytryptamine receptor 2Atarget
Bromocriptine5-hydroxytryptamine receptor 1Btarget
Bromocriptine5-hydroxytryptamine receptor 2Ctarget
BromocriptineDopamine D5 receptortarget
BromocriptineDopamine D1 receptortarget
BromocriptineAlpha-1A adrenergic receptortarget
BromocriptineAlpha-1B adrenergic receptortarget
BromocriptineAlpha-1D adrenergic receptortarget
Bromocriptine5-hydroxytryptamine receptor 7target
BromocriptineP-glycoprotein 1transporter
Lysergic acid diethylamide5-hydroxytryptamine receptor 1Atarget
Lysergic acid diethylamide5-hydroxytryptamine receptor 2Btarget
Lysergic acid diethylamide5-hydroxytryptamine receptor 6target
Lysergic acid diethylamideCytochrome P450 3A4enzyme
Lysergic acid diethylamideCytochrome P450 2D6enzyme
DihydroergocornineSerotonin Receptorstarget
DihydroergocornineBeta adrenergic receptortarget
DihydroergocornineAlpha adrenergic receptortarget
DihydroergocornineCytochrome P450 3A4enzyme
DihydroergocryptineCytochrome P450 3A4enzyme
TergurideCytochrome P450 3A4enzyme
MetergolineSodium channel protein type 2 subunit alphatarget