Ionophores

Name
Ionophores
Accession Number
DBCAT001029
Description

Chemical agents that increase the permeability of biological or artificial lipid membranes to specific ions. Most ionophores are relatively small organic molecules that act as mobile carriers within membranes or coalesce to form ion permeable channels across membranes. Many are antibiotics, and many act as uncoupling agents by short-circuiting the proton gradient across mitochondrial membranes.

Drugs
DrugDrug Description
NystatinA polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species.
Ulapualide ANot Available
LasalocidLasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis.
NarasinNarasin is an agent with coccidiostatic and antibacterial properties.
MaduramicinMaduramicin is an antiprotozoal agent used in veterinary medicine as prophylaxis against coccidiosis. It is a naturally occurring compound which was first isolated from the actinomycete, Actinomadura rubra.
SalinomycinNot Annotated
SemduramicinNot Annotated
NigericinA polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed)
ValinomycinA cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately...
MonensinMonensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds.
Drugs & Drug Targets
DrugTargetType
NystatinErgosteroltarget
NystatinSolute carrier organic anion transporter family member 1B1transporter
NystatinSolute carrier organic anion transporter family member 1B3transporter
Ulapualide AActin, alpha skeletal muscletarget
SalinomycinP-glycoprotein 1transporter
ValinomycinBile salt export pumptransporter
ValinomycinP-glycoprotein 1transporter
MonensinP-glycoprotein 1transporter