Radiation-Protective Agents

Name
Radiation-Protective Agents
Accession Number
DBCAT001143
Description

Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.

Drugs
DrugDrug Description
PentoxifyllineA methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs.
AmifostineA cytoprotective adjuvant used for reduction in the cumulative renal toxicity in patients with ovarian cancer and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
TempolTempol has been used in trials studying the treatment of Anal Cancer.
TetrachlorodecaoxideInvestigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections, cancer/tumors (unspecified), HIV infection, and inflammatory disorders (unspecified).
Sodium copper chlorophyllinSodium copper chlorophyllin (SCC) is a water-soluble and bright green mixture derived from natural chlorophyll that has potential antimutagenic and antioxidant properties . This compound is used as a food...
Arsanilic acidAn arsenical which has been used as a feed additive for enteric conditions in pigs and poultry. It causes blindness and is ototoxic and nephrotoxic in animals. [PubChem]
TeduglutideA glucagon-like peptide-2 (GLP-2) analog used to treat patients with Short Bowel Syndrome (SBS) who require parenteral nutritional support.
HydroquinoneA topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles.
LycopeneAn ingredient found in a variety of supplements and vitamins.
GusperimusGusperimus has been used in trials studying the treatment of Lupus Nephritis, Wegeners Granulomatosis, and Wegener's Granulomatosis.
Buthionine sulfoximineButhionine sulfoximine has been used in trials studying the treatment of Neuroblastoma and Melanoma (Skin).
DeoxyspergualinDeoxyspergualin has been used in trials studying the treatment of Lupus Nephritis, Chronic Rejection, and Diabetes Mellitus, Type 1.
IrsogladineIrsogladine is under investigation in clinical trial NCT02581696 (The Drug-drug Interaction and Safety of Lafutidine and Irsogladine Maleate in Healthy Adult Volunteers).
OxybenzoneA sunscreen agent found in sunscreens that absorbs UV rays.
LawsoneNot Available
Zinc oxideA mineral ingredient of various pharmacological preparations to treat diaper dermatitis and other skin conditions, to protect the epidermis, and to prevent sunburn.
AvobenzoneA sunscreen agent found in sunscreens that absorbs UV rays.
OctinoxateA sunscreen agent found in sunscreens that absorbs UV rays.
EcamsuleA sunscreen agent found in sunscreens that absorbs UV rays.
Titanium dioxideA sunscreen agent found in sunscreens that absorbs UV rays.
OctisalateIngredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer.
HomosalateAs ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer.
Padimate OAn ingredient used in sunscreens to absorb UV radiation.
CepharanthineNot Annotated
PhosphocysteamineNot Annotated
Ammonium trichlorotellurateAmmonium trichlorotellurate is an investigational compound with anti-tumour and anti-inflammatory properties.
Drugs & Drug Targets
DrugTargetType
Pentoxifylline5'-nucleotidasetarget
PentoxifyllineAdenosine receptor A1target
PentoxifyllineAdenosine receptor A2atarget
PentoxifyllineCytochrome P450 1A2enzyme
PentoxifyllinePhosphodiesterase enzymestarget
AmifostineAlkaline phosphatase, germ cell typetarget
AmifostineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
TetrachlorodecaoxideMacrophage erythroblast attachertarget
TetrachlorodecaoxideScavenger receptor cysteine-rich type 1 protein M130target
Arsanilic acidLysozyme Ctarget
TeduglutideGlucagon-like peptide 2 receptortarget
HydroquinoneTyrosinasetarget
HydroquinoneSerum albumincarrier
HydroquinoneLysosomal alpha-glucosidaseenzyme
HydroquinoneCysteinyl leukotriene receptor 1target
OxybenzoneProgesterone receptortarget
OxybenzoneAndrogen receptortarget
OxybenzoneEstrogen receptor alphatarget
OxybenzoneEstrogen receptor betatarget
Titanium dioxideMacrophage receptor MARCOtarget
HomosalateProgesterone receptortarget
HomosalateAndrogen receptortarget
HomosalateEstrogen receptor alphatarget