Antidiuretic Hormone Receptor Antagonists
- Name
- Antidiuretic Hormone Receptor Antagonists
- Accession Number
- DBCAT001166
- Description
Endogenous compounds and drugs that inhibit or block the activity of ANTIDUIRETIC HORMONE RECEPTORS.
- ATC Classification
- Drugs
Drug Drug Description Conivaptan An antidiuretic hormone inhibitor used to raise serum sodium levels. Tolvaptan A selective vasopressin V2-receptor antagonist to slow kidney function decline in patients at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). Also used to treat hypervolemic and euvolemic hyponatremia. Satavaptan Satavaptan is under investigation in clinical trial NCT00359437 (Satavaptan in the Prevention of Ascites Recurrence in Patients With Ascites Due to Cirrhosis of the Liver). Balovaptan Balovaptan is under investigation in clinical trial NCT01793441 (A Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders (ASD)). SRX-246 Not Annotated - Drugs & Drug Targets
Drug Target Type Conivaptan Vasopressin V1a receptor target Conivaptan Vasopressin V2 receptor target Conivaptan Cytochrome P450 3A4 enzyme Conivaptan P-glycoprotein 1 transporter Tolvaptan Vasopressin V2 receptor target Tolvaptan Cytochrome P450 3A4 enzyme Tolvaptan P-glycoprotein 1 transporter Tolvaptan Vasopressin V1a receptor target