Polynucleotides
- Name
- Polynucleotides
- Accession Number
- DBCAT001405
- Description
Complex compounds of high molecular weight occurring in living cells. These are basically of two types, ribonucleic (RNA) and deoxyribonucleic (DNA) acids, both of which consist of nucleotides (nucleoside phosphates linked together by phosphate bridges).
- Drugs
Drug Drug Description Pegaptanib A selective vascular endothelial growth factor (VEGF) antagonist used for the treatment of neovascular (wet) age-related macular degeneration. Fomivirsen Indicated for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS), when other therapy has been ineffective or is considered unsuitable [FDA Label, L1428]. Volanesorsen An antisense oligonucleotide indicated to treat familial chylomicronemia. Viltolarsen An antisense phosphorodiamidate morpholino oligonucleotide specific for exon 53 of the human DMD gene that is capable of inducing exon 53 skipping to produce a functional truncated dystrophin protein in Duchenne muscular dystrophy patients with specific underlying mutations. Casimersen An antisense phosphorodiamidate morpholino oligonucleotide used to treat Duchenne muscular dystrophy patients with mutations amenable to exon 45 skipping. Adenylyl-(3'-5')-uridine 3'-monophosphate Not Available Defibrotide A mixture of single-stranded oligonucleotides used in the treatment of severe hepatic veno-occlusive disease with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation. LErafAON Intended for the treatment of various forms of cancer. AGRO100 Investigated for use/treatment in cancer/tumors (unspecified), kidney cancer, leukemia (myeloid), and pancreatic cancer. LY2181308 Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors. LY2275796 Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors. Egaptivon pegol Platelet aggregation, thrombosis and acute coronary syndromes GTI-2501 Investigated for use/treatment in prostate cancer and solid tumors. ISS-1018 Investigated for use/treatment in colorectal cancer, hepatitis (viral, B), and lymphoma (non-hodgkin's). ISS 1018 is currently being investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent... Mipomersen An oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia. CPG 10101 Investigated for use/treatment in hepatitis (viral, C) and viral infection. NF-kappaB Decoy Investigated for use/treatment in atopic dermatitis, inflammatory disorders (unspecified), and skin infections/disorders. Trabedersen Investigated for use/treatment in brain cancer, colorectal cancer, melanoma, and pancreatic cancer. GEM-231 Investigated for use/treatment in solid tumors. Archexin Investigated for use/treatment in solid tumors. Eteplirsen An antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene that is amenable to exon 51 skipping. Apatorsen Investigated for use/treatment in cancer/tumors (unspecified). IMO-2055 Investigated for use/treatment in renal cell carcinoma, solid tumors, and lung cancer. AEG35156 Investigated for use/treatment in cancer/tumors (unspecified) and leukemia (myeloid). Alicaforsen Investigated for use/treatment in crohn's disease and ulcerative colitis. Pegnivacogin Investigated for use/treatment in thrombosis, coronary artery disease, and vascular diseases. G4460 Investigated for use/treatment in cancer/tumors (unspecified) and leukemia (myeloid). Aprinocarsen Investigated for use/treatment in lung cancer. Edifoligide Investigated for use/treatment in cardiac surgery, peripheral vascular disease, and kidney disease. Abetimus Investigated for use/treatment in kidney disease and systemic lupus erythematosus. Lexaptepid pegol Lexaptepid pegol has been used in trials studying the treatment of Anemia, Inflammation, Chronic Diseases, End Stage Renal Disease, and Anemia of Chronic Disease. Miravirsen Miravirsen has been investigated for the treatment of Hepatitis C and Hepatitis C, Chronic. Nusinersen A medication used to treat spinal muscular atrophy. Drisapersen Not Annotated Oblimersen Not Annotated Inotersen An antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis. Tofersen An antisense oligonucleotide indicated for the treatment of adult amyotrophic lateral sclerosis caused by SOD1 mutation. Cobitolimod Cobitolimod is under investigation in clinical trial NCT03178669 (The Efficacy of Cobitolimod in Patients With Moderate to Severe Active Ulcerative Colitis). Danvatirsen Danvatirsen is under investigation in clinical trial NCT03334617 (Phase II Umbrella Study of Novel Anti-cancer Agents in Patients With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy.). Imetelstat Imetelstat is under investigation in clinical trial NCT01916187 (Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma). Bazlitoran Bazlitoran is under investigation in clinical trial NCT02092909 (Phase 1/2 Dose Escalation Study in Patients With Relapsed or Refractory Waldenstrom's Macroglobulinemia). Mongersen Mongersen is under investigation in clinical trial NCT02957474 (A Study to Evaluate the Effect of Food, Formulation Strength, and a Proton Pump Inhibitor on GED 0301 Pharmacokinetics in Healthy Adult... GTI-2040 GTI-2040 is under investigation in clinical trial NCT00084643 (GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors). ARC-19499 ARC-19499 is under investigation in clinical trial NCT01191372 (First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients). Radavirsen Radavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza). Aganirsen Aganirsen is under investigation in clinical trial NCT02947867 (Trial of Aganirsen in iCRVO Patients at Risk of Developing NVG). Cenersen Cenersen is under investigation in clinical trial NCT02243124 (A Study of Aezea® (Cenersen) in Transfusion Dependent Anemia Associated With Myelodysplastic Syndrome (MDS)). Golodirsen A drug used to treat certain mutations that cause Duchenne muscular dystrophy (DMD). Anivamersen Anivamersen is under investigation in clinical trial NCT01848106 (A Study to Determine the Efficacy and Safety of REG1 Compared to Bivalirudin in Patients Undergoing PCI). Eluforsen Eluforsen is under investigation in clinical trial NCT02532764 (Dose Escalation Study of QR-010 in Homozygous ΔF508 Cystic Fibrosis Patients). ISIS 2503 ISIS 2503 is under investigation in clinical trial NCT00004193 (ISIS 2503 in Treating Patients With Metastatic And/or Locally Recurrent Colorectal Cancer). ISIS 104838 ISIS 104838 is under investigation in clinical trial NCT00048321 (ISIS 104838, an Inhibitor of Tumor Necrosis Factor, for Active Rheumatoid Arthritis). Pelacarsen Pelacarsen is under investigation in clinical trial NCT03070782 (Phase 2 Study of ISIS 681257 (Akcea-apo(a)-lrx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular Disease). Rintatolimod Not Annotated Monarsen Not Annotated Rosomidnar Not Available Hiltonol Not Available Agatolimod Agatolimod is under investigation in clinical trial NCT00471471 (Vaccine Therapy in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery). AVR118 AVR118 represents a new type of biopolymer chemistry that also possesses novel immunomodulator activity. This non-toxic peptide-nucleic acid, which to date has shown no indication of human toxicity, appears to... Cobomarsen Cobomarsen is under investigation in clinical trial NCT02580552 (Safety, Tolerability and Pharmacokinetics of MRG-106 in Patients With Mycosis Fungoides (MF), CLL, DLBCL or ATLL). Tilsotolimod Tilsotolimod is under investigation in clinical trial NCT03865082 (Study of Tilsotolimod in Combination With Nivolumab and Ipilimumab for the Treatment of Solid Tumors (ILLUMINATE-206)). IMT504 IMT504, a non-CpG 24-mer oligodeoxynucleotide, is an immunomodulatory oligonucleotide currently being investigated as a rabies vaccine. AVI-7288 Not Annotated Tominersen Not Annotated Atesidorsen Not Annotated ISTH0036 ISTH0036 is a synthetic 14-mer phosphorothioate antisense oligonucleotide directed against TGF-beta2 mRNA - Drugs & Drug Targets