Molecular Probes

Name
Molecular Probes
Accession Number
DBCAT001717
Description

A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.

Drugs
DrugDrug Description
MipomersenAn oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia.
BevasiranibInvestigated for use/treatment in macular degeneration and diabetic retinopathy.
FomivirsenIndicated for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS), when other therapy has been ineffective or is considered unsuitable [FDA Label, L1428].
PatisiranA transthyretin-directed small interfering RNA used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis.
OblimersenNot Annotated
InotersenAn antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis.
InclisiranA PCSK9-targeting short interfering RNA (siRNA) that lowers plasma LDL-cholesterol levels.
RevusiranRevusiran is under investigation in clinical trial NCT02319005 (ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)).
PafolacianineAn optical imaging agent indicated in adult patients with ovarian cancer as an adjunct for intraoperative identification of malignant lesions.
GolodirsenA drug used to treat certain mutations that cause Duchenne muscular dystrophy (DMD).
Drugs & Drug Targets
DrugTargetType
MipomersenmRNA of ApoB-100target
BevasiranibVascular endothelial growth factor Atarget
Fomivirsen30 kDa immediate-early protein 2target
Fomivirsen45 kDa immediate-early protein 2target
PatisiranTransthyretin mRNAtarget
PatisiranSerum albumincarrier
Patisiranalpha1-acid glycoproteincarrier
InotersenTransthyretin mRNAtarget
InclisiranProprotein convertase subtilisin/kexin type 9target
RevusiranTransthyretintarget
PafolacianineFolate receptor alphatarget
PafolacianineSolute carrier organic anion transporter family member 1B1transporter
PafolacianineSolute carrier organic anion transporter family member 1B3transporter
PafolacianineSolute carrier family 22 member 6transporter
GolodirsenDystrophintarget