Benzoflavones

Name
Benzoflavones
Accession Number
DBCAT001849
Description

Organic compounds containing a BENZENE ring attached to a flavone group. Some of these are potent arylhydrocarbon hydroxylase inhibitors. They may also inhibit the binding of NUCLEIC ACIDS to BENZOPYRENES and related compounds. The designation includes all isomers; the 7,8-isomer is most frequently encountered.

Drugs
DrugDrug Description
beta-Naphthoflavoneβ-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and induces cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). It may be a chemopreventive agent.
Drugs & Drug Targets
DrugTargetType
beta-NaphthoflavoneCytochrome P450 1A2enzyme
beta-NaphthoflavoneEstrogen receptor alphatarget
beta-NaphthoflavoneSteroid hormone receptor ERR1target
beta-NaphthoflavoneCOUP transcription factor 1target
beta-NaphthoflavoneAryl hydrocarbon receptortarget
beta-NaphthoflavoneCytochrome P450 1B1target