Benzodiazepines and benzodiazepine derivatives

Name
Benzodiazepines and benzodiazepine derivatives
Accession Number
DBCAT000450  (DBCAT002184, DBCAT002360)
Description

A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.

ATC Classification
Drugs
DrugDrug Description
LorazepamA short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.
TemazepamA short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia.
AlprazolamA triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression.
ChlordiazepoxideA benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period.
Clorazepic acidA benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal.
MidazolamA short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders.
FlurazepamA long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia.
DiazepamA long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures.
OxazepamAn intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia.
TriazolamA benzodiazepine used for short term treatment of insomnia.
ClonazepamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures.
EstazolamA benzodiazepine used for the short-term management of insomnia.
BromazepamA short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety.
NitrazepamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures.
ClobazamA benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
CamazepamCamazepam has been used in placebo controlled studies for the treatment of patients suffering from anxiety and depression.
DelorazepamA benzodiazepine used to manage severe anxiety disorders and insomnia.
FlunitrazepamA benzodiazepine used to manage anxiety disorders and insomnia.
FludiazepamUsed for the short-term treatment of anxiety disorders.
PrazepamA benzodiazepine used to manage more severe forms of anxiety disorders.
EtizolamA thienodiazepine derivative used to treat anxiety and insomnia.
MedazepamA long-acting benzodiazepine used for its sedative and anxiolytic properties.
DoxefazepamNot Annotated
LormetazepamA benzodiazepine indicated in the treatment of anxiety and the induction of anesthesia.
NordazepamA benzodiazepine indicated in the treatment of insomnia.
AdinazolamFor the treatment of anxiety and status epilepticus.
HalazepamUsed to relieve anxiety, nervousness, and tension associated with anxiety disorders.
Ethyl loflazepateNot Available
CloxazolamUsed primarily as an anti-anxiety agent. Typically used short term, and may be given as a single dose of up to 100mcg/kg to reduce anxiety and tension experienced prior to...
ClotiazepamA thienodiazepine used to manage anxiety disorders and insomnia.
KetazolamA long-acting benzodiazepine used to manage anxiety and insomnia.
CinolazepamA benzodiazepine used to manage severe and debilitating forms of sleep disorders of various origins in adults.
TofisopamFor the treatment of anxiety and alcohol withdrawal.
BrotizolamA benzodiazepine analogue with sedative-hypnotic properties used for short-term treatment of severe or debilitating insomnia.
PinazepamA benzodiazepine indicated in the treatment of anxiety and severe insomnia.
LoprazolamLoprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent...
QuazepamA long-acting benzodiazepine used to manage insomnia.
Oxazepam acetateNot Annotated
CinazepamNot Annotated
1,2-BenzodiazepineBenzodiazepine is under investigation for the prevention of Delirium and C.Surgical Procedure; Cardiac. Benzodiazepine has been investigated for the treatment of Obesity, Sleep Apnea, Obstructive, and Disorders of Gallbladder, Biliary...
BentazepamNot Annotated
MexazolamA benzodiazepine indicated to treat anxiety with or without psychoneurotic conditions.
RemimazolamAn ultra short-acting benzodiazepine used for the induction and maintenence of procedural sedation during short procedures.
Drugs & Drug Targets
DrugTargetType
LorazepamUDP-glucuronosyltransferase 2B15enzyme
LorazepamGABA(A) Receptortarget
LorazepamCytochrome P450 3A4enzyme
LorazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
TemazepamCytochrome P450 3A4enzyme
TemazepamCytochrome P450 2B6enzyme
TemazepamCytochrome P450 2C9enzyme
TemazepamGABA(A) Receptortarget
TemazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
AlprazolamCytochrome P450 3A4enzyme
AlprazolamCytochrome P450 2C9enzyme
AlprazolamCytochrome P450 3A5enzyme
AlprazolamCytochrome P450 3A7enzyme
AlprazolamGABA(A) Receptortarget
AlprazolamSerum albumincarrier
Alprazolamalpha1-acid glycoproteincarrier
AlprazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ChlordiazepoxideGABA(A) Receptortarget
ChlordiazepoxideGABA(A) Receptor Benzodiazepine Binding Sitetarget
ChlordiazepoxideCytochrome P450 3A4enzyme
Clorazepic acidCytochrome P450 3A4enzyme
Clorazepic acidGABA(A) Receptortarget
Clorazepic acidGABA(A) Receptor Benzodiazepine Binding Sitetarget
MidazolamCytochrome P450 3A4enzyme
MidazolamCytochrome P450 3A5enzyme
MidazolamUDP-glucuronosyltransferase 1-4enzyme
MidazolamCytochrome P450 3A7enzyme
MidazolamGABA(A) Receptortarget
MidazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MidazolamP-glycoprotein 1transporter
MidazolamSerum albumincarrier
MidazolamAlpha-1-acid glycoprotein 1carrier
MidazolamAdenosine receptor A2atarget
MidazolamExcitatory amino acid transporter 2transporter
MidazolamUDP-glucuronosyltransferase 2B7enzyme
MidazolamUDP-glucuronosyltransferase 2B4enzyme
FlurazepamCytochrome P450 3A4enzyme
FlurazepamP-glycoprotein 1transporter
FlurazepamCytochrome P450 2E1enzyme
FlurazepamCytochrome P450 2A6enzyme
FlurazepamSolute carrier family 22 member 2transporter
FlurazepamGABA(A) Receptortarget
FlurazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DiazepamCytochrome P450 3A4enzyme
DiazepamSerum albumincarrier
DiazepamCytochrome P450 2C9enzyme
DiazepamCytochrome P450 2C19enzyme
DiazepamCytochrome P450 3A5enzyme
DiazepamCytochrome P450 3A7enzyme
DiazepamP-glycoprotein 1transporter
DiazepamCytochrome P450 2B6enzyme
DiazepamProstaglandin G/H synthase 1enzyme
DiazepamCytochrome P450 2C18enzyme
DiazepamCytochrome P450 2C8enzyme
DiazepamGABA(A) Receptortarget
DiazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
OxazepamUDP-glucuronosyltransferase 2B15enzyme
OxazepamUDP-glucuronosyltransferase 2B7enzyme
OxazepamUDP-glucuronosyltransferase 1-9enzyme
OxazepamGABA(A) Receptortarget
OxazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
OxazepamSerum albumincarrier
TriazolamCytochrome P450 3A4enzyme
TriazolamCytochrome P450 3A5enzyme
TriazolamCytochrome P450 3A7enzyme
TriazolamCytochrome P450 2C8enzyme
TriazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
TriazolamGABA(A) Receptortarget
ClonazepamCytochrome P450 3A4enzyme
ClonazepamSerum albumincarrier
ClonazepamCytochrome P450 2E1enzyme
ClonazepamArylamine N-acetyltransferase 2enzyme
ClonazepamGABA(A) Receptortarget
ClonazepamNuclear receptor subfamily 1 group I member 2target
ClonazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
EstazolamCytochrome P450 3A4enzyme
EstazolamGABA(A) Receptortarget
EstazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
BromazepamCytochrome P450 1A2enzyme
BromazepamCytochrome P450 2C19enzyme
BromazepamCytochrome P450 2E1enzyme
BromazepamGABA(A) Receptortarget
BromazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
NitrazepamSodium channel protein type 1 subunit alphatarget
NitrazepamCytochrome P450 3A4enzyme
NitrazepamCytochrome P450 2E1enzyme
NitrazepamGABA(A) Receptortarget
NitrazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ClobazamCytochrome P450 2C19enzyme
ClobazamCytochrome P450 3A4enzyme
ClobazamCytochrome P450 2B6enzyme
ClobazamCytochrome P450 2C18enzyme
ClobazamP-glycoprotein 1transporter
ClobazamGABA(A) Receptortarget
ClobazamCytochrome P450 2D6enzyme
ClobazamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ClobazamSerum albumincarrier
ClobazamAlpha-1-acid glycoprotein 1carrier
ClobazamCytochrome P450 2C9enzyme
ClobazamUDP-glucuronosyltransferase 1-4enzyme
ClobazamUDP-glucuronosyltransferase 1-6enzyme
ClobazamUDP-glucuronosyltransferase 2B4enzyme
ClobazamUDP-glucuronosyltransferase 1-1enzyme
ClobazamCytochrome P450 1A2enzyme
ClobazamCytochrome P450 2C8enzyme
ClobazamCytochrome P450 3A5enzyme
ClobazamCytochrome P450 3A7enzyme
CamazepamGABA(A) Receptortarget
CamazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DelorazepamGABA(A) Receptortarget
DelorazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
FlunitrazepamCytochrome P450 2C19enzyme
FlunitrazepamUDP-glucuronosyltransferase 2B7enzyme
FlunitrazepamCytochrome P450 2A6enzyme
FlunitrazepamCytochrome P450 2B6enzyme
FlunitrazepamCytochrome P450 2C9enzyme
FlunitrazepamCytochrome P450 3A4enzyme
FlunitrazepamCytochrome P450 2E1enzyme
FlunitrazepamUDP-glucuronosyltransferase 1-1enzyme
FlunitrazepamUDP-glucuronosyltransferase 1-3enzyme
FlunitrazepamGABA(A) Receptortarget
FlunitrazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
FludiazepamGamma-aminobutyric acid receptor subunit alpha-2target
FludiazepamGamma-aminobutyric acid receptor subunit alpha-1target
FludiazepamGamma-aminobutyric acid receptor subunit alpha-3target
FludiazepamGamma-aminobutyric acid receptor subunit alpha-5target
FludiazepamGamma-aminobutyric acid receptor subunit gamma-1target
FludiazepamGamma-aminobutyric acid receptor subunit gamma-2target
FludiazepamGamma-aminobutyric acid receptor subunit gamma-3target
FludiazepamGamma-aminobutyric acid receptor subunit beta-1target
FludiazepamGamma-aminobutyric acid receptor subunit beta-2target
FludiazepamGamma-aminobutyric acid receptor subunit beta-3target
FludiazepamGamma-aminobutyric acid receptor subunit deltatarget
FludiazepamGamma-aminobutyric acid receptor subunit epsilontarget
FludiazepamGamma-aminobutyric acid receptor subunit pitarget
FludiazepamGamma-aminobutyric acid receptor subunit rho-1target
FludiazepamGamma-aminobutyric acid receptor subunit rho-2target
FludiazepamGamma-aminobutyric acid receptor subunit rho-3target
PrazepamCytochrome P450 3A4enzyme
PrazepamGABA(A) Receptortarget
PrazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
EtizolamCytochrome P450 3A4enzyme
EtizolamCytochrome P450 2C18enzyme
EtizolamCytochrome P450 2C19enzyme
EtizolamPlatelet-activating factor receptortarget
EtizolamGABA(A) Receptortarget
EtizolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MedazepamGABA(A) Receptortarget
MedazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DoxefazepamGABA(A) Receptortarget
DoxefazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
LormetazepamGABA(A) Receptortarget
LormetazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
NordazepamGABA(A) Receptortarget
NordazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
AdinazolamCytochrome P450 2C19enzyme
AdinazolamCytochrome P450 3A4enzyme
AdinazolamGABA(A) Receptortarget
AdinazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
HalazepamGABA(A) Receptortarget
HalazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
Ethyl loflazepateGABA(A) Receptortarget
Ethyl loflazepateGABA(A) Receptor Benzodiazepine Binding Sitetarget
CloxazolamGABA(A) Receptortarget
CloxazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ClotiazepamCytochrome P450 2B6enzyme
ClotiazepamCytochrome P450 2C18enzyme
ClotiazepamCytochrome P450 2C19enzyme
ClotiazepamCytochrome P450 3A4enzyme
ClotiazepamGABA(A) Receptortarget
ClotiazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
KetazolamCytochrome P450 3A4enzyme
KetazolamP-glycoprotein 1transporter
KetazolamSerum albumincarrier
KetazolamGABA(A) Receptortarget
KetazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
CinolazepamGABA(A) Receptortarget
CinolazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
TofisopamcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
TofisopamcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
TofisopamcGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
TofisopamcGMP-dependent 3',5'-cyclic phosphodiesterasetarget
TofisopamCytochrome P450 3A4enzyme
BrotizolamCytochrome P450 3A4enzyme
BrotizolamGABA(A) Receptortarget
BrotizolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
PinazepamGABA(A) Receptortarget
PinazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
LoprazolamGABA(A) Receptortarget
LoprazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
QuazepamCytochrome P450 2C19enzyme
QuazepamCytochrome P450 2C9enzyme
QuazepamCytochrome P450 3A4enzyme
QuazepamGABA(A) Receptortarget
QuazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
Oxazepam acetateGABA(A) Receptortarget
Oxazepam acetateGABA(A) Receptor Benzodiazepine Binding Sitetarget
CinazepamGABA(A) Receptortarget
CinazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
1,2-BenzodiazepineCytochrome P450 3A4enzyme
1,2-BenzodiazepineGABA(A) Receptortarget
1,2-BenzodiazepineGABA(A) Receptor Benzodiazepine Binding Sitetarget
BentazepamGABA(A) Receptortarget
BentazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MexazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MexazolamCytochrome P450 3A4enzyme
MexazolamGABA(A) Receptortarget
RemimazolamLiver carboxylesterase 1enzyme
RemimazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
RemimazolamGABA(A) Receptortarget
RemimazolamSerum albumincarrier