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Showing drug card for Polymyxin B Sulfate (DB00781)

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Version 2.5
Creation Date 2005-06-13 13:24:05
Update Date 2009-06-23 18:08:15
Primary Accession Number DB00781
Secondary Accession Number
  • APRD01190
Name Polymyxin B Sulfate
Drug Type
  • Approved
  • Small Molecule
Description Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
Synonyms
  1. Polymixin B sulfate
  2. Polymyxin B sulfate salt
  3. Polymyxin B sulphate
Brand Names
  1. Aerosporin
  2. Poly-RX
Brand Mixtures
  1. Anaprime OPH Gel (Flumethasone + Neomycin sulfate + Polymyxin B sulfate)
  2. Antibiotic Cream (Gramicidin + Polymyxin B sulfate)
  3. Antibiotic Lozenges (Benzocaine + Cetylpyridinium Chloride + Polymyxin B sulfate + Tyrothricin)
  4. Antibiotic Ointment (Bacitracin + Polymyxin B sulfate)
  5. Bacitracin-Neomycin Polymyxin Ont (Bacitracin Zinc + Neomycin sulfate + Polymyxin B sulfate)
  6. Bacitracin-Neomycin-Polymyxin Oph Ont (Bacitracin Zinc + Neomycin sulfate + Polymyxin B sulfate)
  7. Band-Aid Brand Antibiotic (Bacitracin Zinc + Polymyxin B sulfate)
  8. Band-Aid-S-1 (Bacitracin Zinc + Polymyxin B sulfate)
  9. Cortisporin (Bacitracin Zinc + Hydrocortisone + Neomycin sulfate + Polymyxin B sulfate)
  10. First Aid Antibiotic (Bacitracin Zinc + Polymyxin B sulfate)
  11. First Aid Antibiotic Ointment (Bacitracin Zinc + Polymyxin B sulfate)
  12. Forte Topical Suspension (Hydrocortisone Acetate + Hydrocortisone Sodium Succinate + Neomycin sulfate + Penicillin G Procaine + Polymyxin B sulfate)
  13. Gercillin (Bacitracin + Benzocaine + Polymyxin B sulfate + Tyrothricin)
  14. Lanabiotic Ont (Bacitracin + Polymyxin B sulfate)
  15. Laryngets Loz (Benzocaine + Cetylpyridinium Chloride + Polymyxin B sulfate + Tyrothricin)
  16. Lidomyxin (Lidocaine Hydrochloride + Polymyxin B sulfate)
  17. Lidosporin Cream (Gramicidin + Lidocaine Hydrochloride + Polymyxin B sulfate)
  18. Lidosporin Ear Drops (Lidocaine Hydrochloride + Polymyxin B sulfate)
  19. Mastitis Care (Neomycin sulfate + Penicillin G Potassium + Polymyxin B sulfate + Streptomycin sulfate)
  20. Mycitracin OPH ONT (Bacitracin + Neomycin sulfate + Polymyxin B sulfate)
  21. Neo Bace Ophthalmic Ointment (Bacitracin + Polymyxin B sulfate)
  22. Neospan Mastitis Treatment (Neomycin sulfate + Penicillin G Potassium + Polymyxin B sulfate + Streptomycin sulfate)
  23. Neosporin Antibiotic Cream (Gramicidin + Neomycin sulfate + Polymyxin B sulfate)
  24. Neosporin Eye-Ear Solution (Gramicidin + Neomycin sulfate + Polymyxin B sulfate)
  25. Neosporin Irrigating Solution (Neomycin sulfate + Polymyxin B sulfate)
  26. Neosporin Ointment (Bacitracin (Bacitracin Zinc) + Neomycin sulfate + Polymyxin B sulfate)
  27. Neosporin Ophthalmic Ointment (Bacitracin (Bacitracin Zinc) + Neomycin sulfate + Polymyxin B sulfate)
  28. Neotopic Ointment (Bacitracin (Bacitracin Zinc) + Neomycin sulfate + Polymyxin B sulfate)
  29. Ophthocort Ont (Chloramphenicol + Hydrocortisone Acetate + Polymyxin B sulfate)
  30. Optiprime Oph Gel (Neomycin sulfate + Polymyxin B sulfate)
  31. Ozonol Antibiotic Plus - Ointment (Bacitracin + Lidocaine Hydrochloride + Polymyxin B sulfate)
  32. Ozonol Antibiotic Plus Ont (Bacitracin + Lidocaine Hydrochloride + Polymyxin B sulfate)
  33. Pms-Polytrimethoprim (Polymyxin B sulfate + Trimethoprim (Trimethoprim sulfate))
  34. Polycidin Eye, Ear Drops (Gramicidin + Polymyxin B sulfate)
  35. Polycidin Ophthalmic Ointment (Bacitracin (Bacitracin Zinc) + Polymyxin B sulfate)
  36. Polyderm Antibiotic Ointment (Bacitracin + Lidocaine Hydrochloride + Polymyxin B sulfate)
  37. Polyderm Ointment Usp (Bacitracin Zinc + Polymyxin B sulfate)
  38. Polysporin Antibiotic Burn Cream (Gramicidin + Lidocaine Hydrochloride + Polymyxin B sulfate)
  39. Polysporin Antibiotic Ointment (Bacitracin + Polymyxin B sulfate)
  40. Polysporin Burn Formula Cream (Gramicidin + Lidocaine Hydrochloride + Polymyxin B sulfate)
  41. Polysporin Cream (Gramicidin + Polymyxin B sulfate)
  42. Polysporin Eye and Ear Drops Sterile (Gramicidin + Polymyxin B sulfate)
  43. Polysporin Sterile Ophthalmic Ointment (Bacitracin (Bacitracin Zinc) + Polymyxin B sulfate)
  44. Polysporin Topical First Aid Antibiotic Ointment (Bacitracin + Polymyxin B sulfate)
  45. Polysporin Triple Antibiotic Ointment (Bacitracin + Gramicidin + Polymyxin B sulfate)
  46. Polytopic Ont (Bacitracin + Polymyxin B sulfate)
  47. Polytracin Ont (Bacitracin Zinc + Polymyxin B sulfate)
  48. Pulmosirum Pastille (Benzocaine + Cetylpyridinium Chloride + Polymyxin B sulfate + Tyrothricin)
  49. Sandoz Cortimyxin (Bacitracin (Bacitracin Zinc) + Hydrocortisone + Neomycin sulfate + Polymyxin B sulfate)
  50. Septomixine Forte (Dexamethasone + Halethazole Tartrate + Neomycin sulfate + Polymyxin B sulfate + Tyrothricin)
  51. Surolan Drops (Miconazole Nitrate + Polymyxin B sulfate + Prednisolone Acetate)
  52. Synalar Bi-Otic Solution (Fluocinolone Acetonide + Neomycin sulfate + Polymyxin B sulfate)
Chemical IUPAC Name N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide; sulfuric acid
Chemical Formula C56H100N16O17S
Chemical Structure Structure
CAS Registry Number 1405-20-5
InChI Identifier InChI=1/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4)/f/h62-72H;1-2H
InChI Key HFMDLUQUEXNBOP-VTFLQOHRCV
KEGG Drug D01066 Link Image
KEGG Compound C11613 Link Image
PubChem Compound 5702105 Link Image
PubChem Substance 8149488 Link Image
ChEBI ID Not Available
PharmGKB ID PA451028 Link Image
HET ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 02242485 Link Image
RxList Link http://www.rxlist.com/cgi/generic3/polymyxin.htm Link Image
PDRhealth Link Not Available
Wikipedia Link http://en.wikipedia.org/wiki/Polymyxin_B Link Image
FDA Label Not Available
Material Safety Data Sheet (MSDS)
Synthesis Reference Not Available
Average Molecular Weight 1301.5550
Monoisotopic Molecular Weight 1300.7173
State Solid
Melting Point Not Available
Experimental Water Solubility 25 mg/mL Source: PhysProp
Predicted Water Solubility Not Available Calculated using ALOGPS
Experimental LogP/Hydrophobicity -4.861 Source: PhysProp
Predicted LogP Not Available Calculated using ALOGPS
Experimental LogS Not Available
Predicted LogS Not Available Calculated using ALOGPS
Experimental Caco2 Permeability Not Available
pKa/Isoelectric Point Not Available
Mass Spectrum Not Available
MOL File Show Link Image | Download Link Image
SDF File Show Link Image | Download Link Image
PDB File Show Link Image | Download Link Image
2D Structure
3D Structure
Experimental PDB ID Not Available
Isomeric SMILES OS(O)(=O)=O.CC[C@@H](C)CCCCC(=O)N[C@H](CCN)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCN)C(=O)N[C@@H]1CCNC(=O)[C@H](NC(=O)[C@@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O
Canonical SMILES OS(O)(=O)=O.CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC1=O)C(C)O
Drug Category
  • Anti-Bacterial Agents
ATC Codes
AHFS Codes Not Available
Indication For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
Pharmacology Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant.
Mechanism of Action Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate binds to and interferes with the permeability of the bacterial cytoplasmic membrane.
Absorption Not absorbed from the normal alimentary tract.
Toxicity Overdose can cause stomach pains, vomiting, and diarrhea.
Protein Binding Not Available
Biotransformation Not Available
Half Life Not Available
Dosage Forms
Form Route
Injection, solution Intramuscular
Injection, solution Intravenous drip
Powder, for solution Intrathecal
Powder, for solution Ophthalmic
Patient Information Not Available
Contraindications Show Link Image
Interactions Show Link Image
Drug Interactions Not Available
Food Interactions Not Available
Pathways Not Available
General References
  1. Wikipedia Link Image
  2. RxList Link Image
Organisms Affected
  • Enteric bacteria and other eubacteria

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government. This project is also supported in part by GenomeQuest, Inc., an enterprise genomic information company serving the life science community.