D-Glutamine
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Identification
- Generic Name
- D-Glutamine
- DrugBank Accession Number
- DB02174
- Background
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the principal carrier of nitrogen in the body and is an important energy source for many cells.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 146.1445
Monoisotopic: 146.069142196 - Chemical Formula
- C5H10N2O3
- Synonyms
- (2R)-2-amino-4-carbamoylbutanoic acid
- (2R)-2,5-diamino-5-oxopentanoic acid
- (R)-2,5-diamino-5-oxopentanoic acid
- D-2-Aminoglutaramic acid
- D-Glutamin
- D-Glutaminsäure-5-amid
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UGlutamate racemase Not Available Aquifex pyrophilus - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as d-alpha-amino acids. These are alpha amino acids which have the D-configuration of the alpha-carbon atom.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Amino acids, peptides, and analogues
- Direct Parent
- D-alpha-amino acids
- Alternative Parents
- Fatty acids and conjugates / Amino acids / Monocarboxylic acids and derivatives / Carboxylic acids / Carboximidic acids / Organopnictogen compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Aliphatic acyclic compound / Amine / Amino acid / Carbonyl group / Carboximidic acid / Carboximidic acid derivative / Carboxylic acid / D-alpha-amino acid / Fatty acid / Hydrocarbon derivative
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- D-alpha-amino acid, glutamine (CHEBI:17061) / Other amino acids (C00819)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 63HB36CA2Y
- CAS number
- 5959-95-5
- InChI Key
- ZDXPYRJPNDTMRX-GSVOUGTGSA-N
- InChI
- InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m1/s1
- IUPAC Name
- (2R)-2-amino-4-carbamoylbutanoic acid
- SMILES
- N[C@H](CCC(N)=O)C(O)=O
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0003423
- KEGG Compound
- C00819
- PubChem Compound
- 145815
- PubChem Substance
- 46508385
- ChemSpider
- 128633
- BindingDB
- 181129
- ChEBI
- 17061
- ChEMBL
- CHEMBL1232207
- ZINC
- ZINC000001532609
- Guide to Pharmacology
- GtP Drug Page
- PDBe Ligand
- DGN
- PDB Entries
- 1b74 / 1bfw / 1epr / 1yj1 / 1zea / 2fcm / 2ixv / 2jx4 / 2ldj / 2q33 … show 72 more
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 97.8 mg/mL ALOGPS logP -3.3 ALOGPS logP -4 Chemaxon logS -0.17 ALOGPS pKa (Strongest Acidic) 2.15 Chemaxon pKa (Strongest Basic) 9.31 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 106.41 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 33.11 m3·mol-1 Chemaxon Polarizability 13.59 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 130.1993184 predictedDarkChem Lite v0.1.0 [M-H]- 130.1591184 predictedDarkChem Lite v0.1.0 [M-H]- 124.179276 predictedDeepCCS 1.0 (2019) [M+H]+ 130.9128184 predictedDarkChem Lite v0.1.0 [M+H]+ 130.2160184 predictedDarkChem Lite v0.1.0 [M+H]+ 128.00816 predictedDeepCCS 1.0 (2019) [M+Na]+ 130.6338184 predictedDarkChem Lite v0.1.0 [M+Na]+ 130.0826184 predictedDarkChem Lite v0.1.0 [M+Na]+ 137.1468 predictedDeepCCS 1.0 (2019)
Targets
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1. DetailsGlutamate racemase
- Kind
- Protein
- Organism
- Aquifex pyrophilus
- Pharmacological action
- Unknown
- General Function
- Glutamate racemase activity
- Specific Function
- Provides the (R)-glutamate required for cell wall biosynthesis. Converts L- or D-glutamate to D- or L-glutamate, respectively, but not other amino acids such as alanine, aspartate, and glutamine.
- Gene Name
- murI
- Uniprot ID
- P56868
- Uniprot Name
- Glutamate racemase
- Molecular Weight
- 27992.485 Da
References
Drug created at June 13, 2005 13:24 / Updated at June 12, 2020 16:52