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Showing drug card for 2-Propanol, Isopropanol (DB04402)

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Version 2.5
Creation Date 2005-06-13 13:24:05
Update Date 2008-08-26 14:29:57
Primary Accession Number DB04402
Secondary Accession Number
  • EXPT01905
Name 2-Propanol, Isopropanol
Drug Type
  • Experimental
  • Small Molecule
Description An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic. [PubChem]
Synonyms Not Available
Brand Names Not Available
Brand Mixtures Not Available
Chemical IUPAC Name propan-2-ol
Chemical Formula C3H8O
Chemical Structure Structure
CAS Registry Number Not Available
InChI Identifier InChI=1/C3H8O/c1-3(2)4/h3-4H,1-2H3
InChI Key KFZMGEQAYNKOFK-UHFFFAOYAH
KEGG Drug Not Available
KEGG Compound Not Available
PubChem Compound 3776 Link Image
PubChem Substance 7888433 Link Image
ChEBI ID Not Available
PharmGKB ID Not Available
HET ID IOH Link Image
GenBank ID Not Available
Drug ID Number [DIN] Not Available
RxList Link Not Available
PDRhealth Link Not Available
Wikipedia Link Not Available
FDA Label Not Available
Material Safety Data Sheet (MSDS) Not Available
Synthesis Reference Not Available
Average Molecular Weight 60.0950
Monoisotopic Molecular Weight 60.0575
State Solid
Melting Point Not Available
Experimental Water Solubility Not Available Source: PhysProp
Predicted Water Solubility 3.78e+02 mg/mL Calculated using ALOGPS
Experimental LogP/Hydrophobicity Not Available Source: PhysProp
Predicted LogP 0.04 Calculated using ALOGPS
Experimental LogS Not Available
Predicted LogS 0.80 Calculated using ALOGPS
Experimental Caco2 Permeability Not Available
pKa/Isoelectric Point Not Available
Mass Spectrum Not Available
MOL File Show Link Image | Download Link Image
SDF File Show Link Image | Download Link Image
PDB File Show Link Image | Download Link Image
2D Structure
3D Structure
Experimental PDB ID 1M8A Link Image
Experimental PDB File Show
Experimental PDB Structure
Isomeric SMILES CC(C)O
Canonical SMILES CC(C)O
Drug Category
  • Solvents
ATC Codes Not Available
AHFS Codes Not Available
Indication Not Available
Pharmacology Not Available
Mechanism of Action Not Available
Absorption Not Available
Toxicity Not Available
Protein Binding Not Available
Biotransformation Not Available
Half Life Not Available
Dosage Forms Not Available
Patient Information Not Available
Contraindications Not Available
Interactions Not Available
Drug Interactions Not Available
Food Interactions Not Available
Pathways Not Available
General References Not Available
Organisms Affected Not Available
Targets
  1. Nitric-oxide synthase, endothelial
  2. Sex hormone-binding globulin
  3. Glutathione S-transferase A2
  4. Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
  5. GTPase HRas
  6. Oxysterols receptor LXR-beta
  7. Putative 1-aminocyclopropane-1-carboxylate deaminase
  8. ABC transporter ATP-binding protein MJ0796
  9. Small inducible cytokine A20
  10. Heme oxygenase 1
  11. ATP-dependent Clp protease ATP-binding subunit clpA
  12. Uridine phosphorylase, putative
  13. Cag-Z
  14. Esterase EstB
  15. Aeromonas caviae phaC PHA synthase,complete cds
  16. YojF protein
  17. Hypothetical protein
  18. Phospholipase A2-3
  19. Trp operon repressor
Drug Target 1 [top]
Target 1 ID 291
Target 1 Name Nitric-oxide synthase, endothelial
Target 1 Synonyms
  1. Constitutive NOS
  2. EC 1.14.13.39
  3. EC-NOS
  4. Endothelial NOS
  5. NOS type III
  6. NOSIII
  7. cNOS
  8. eNOS
Target 1 Gene Name NOS3
Target 1 Protein Sequence >Nitric-oxide synthase, endothelial 
GNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLTQ
PPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPE
QLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA
PRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDF
RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPE
LFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTE
IGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHH
AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK
GSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRL
FRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP
RPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC
AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAAR
DIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATILV
RLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGPP
PGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRYE
EWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLA
YRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPF
RGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREP
DNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELDE
AGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDTN
SP
Target 1 Number of Residues 1222
Target 1 Molecular Weight 133159
Target 1 Theoretical pI 7.27
Target 1 GO Classification
Function
cofactor binding
coenzyme binding
NADP binding
purine nucleotide binding
adenyl nucleotide binding
FAD binding
tetrapyrrole binding
heme binding
protein binding
calmodulin binding
ion binding
cation binding
transition metal ion binding
iron ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
nitric-oxide synthase activity
binding
nucleotide binding
FMN binding
transporter activity
electron transporter activity
catalytic activity
oxidoreductase activity
Process
biosynthesis
nitric oxide biosynthesis
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
Component
Not Available
Target 1 General Function Inorganic ion transport and metabolism
Target 1 Specific Function Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets
Target 1 Pathways
Name SMPDB Link KEGG Link
Arginine and proline metabolism SMP00020 Link Image map00330 Link Image
Target 1 Reactions
  • L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+
Target 1 Pfam Domain Function
Target 1 Signals
  • None
Target 1 Transmembrane Regions
  • None
Target 1 Essentiality Non-Essential
Target 1 GenBank ID Protein 189212 Link Image
Target 1 UniProtKB/Swiss-Prot ID P29474 Link Image
Target 1 UniProtKB/Swiss-Prot Entry Name NOS3_HUMAN Link Image
Target 1 PDB ID 3NOS Link Image
Target 1 PDB File Show
Target 1 3D Structure
Target 1 Cellular Location Not Available
Target 1 Gene Sequence >3612 bp 
ATGGGCAACTTGAAGAGCGTGGCCCAGGAGCCTGGGCCACCCTGCGGCCTGGGGCTGGGG
CTGGGCCTTGGGCTGTGCGGCAAGCAGGGCCCAGCCACCCCGGCCCCTGAGCCCAGCCGG
GCCCCAGCATCCCTACTCCCACCAGCGCCAGAACACAGCCCCCCGAGCTCCCCGCTAACC
CAGCCCCCAGAGGGGCCCAAGTTCCCTCGTGTGAAGAACTGGGAGGTGGGGAGCATCACC
TATGACACCCTCAGCGCCCAGGCGCAGCAGGATGGGCCCTGCACCCCAAGACGCTGCCTG
GGCTCCCTGGTATTTCCACGGAAACTACAGGGCCGGCCCTCCCCCGGCCCCCCGGCCCCT
GAGCAGCTGCTGAGTCAGGCCCGGGACTTCATCAACCAGTACTACAGCTCCATTAAGAGG
AGCGGCTCCCAGGCCCACGAACAGCGGCTTCAAGAGGTGGAAGCCGAGGTGGCAGCCACA
GGCACCTACCAGCTTAGGGAGAGCGAGCTGGTGTTCGGGGCTAAGCAGGCCTGGCGCAAC
GCTCCCCGCTGCGTGGGCCGGATCCAGTGGGGGAAGCTGCAGGTGTTCGATGCCCGGGAC
TGCAGGTCTGCACAGGAAATGTTCACCTACATCTGCAACCACATCAAGTATGCCACCAAC
CGGGGCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGCGCTGCCCTGGCCGAGGAGAC
TTCCGAATCTGGAACAGCCAGCTGGTGCGCTACGCGGGCTACCGGCAGCAGGACGGCTCT
GTGCGGGGGGACCCAGCCAACGTGGAGATCACCGAGCTCTGCATTCAGCACGGCTGGACC
CCAGGAAACGGTCGCTTCGACGTGCTGCCCCTGCTGCTGCAGGCCCCAGATGAGCCCCCA
GAACTCTTCCTTCTGCCCCCCGAGCTGGTCCTTGAGGTGCCCCTGGAGCACCCCACGCTG
GAGTGGTTTGCAGCCCTGGGCCTGCGCTGGTACGCCCTCCCGGCAGTGTCCAACATGCTG
CTGGAAATTGGGGGCCTGGAGTTCCCCGCAGCCCCCTTCAGTGGCTGGTACATGAGCACT
GAGATCGGCACGAGGAACCTGTGTGACCCTCACCGCTACAACATCCTGGAGGATGTGGCT
GTCTGCATGGACCTGGATACCCGGACCACCTCGTCCCTGTGGAAAGACAAGGCAGCAGTG
GAAATCAACGTGGCCGTGCTGCACAGTTACCAGCTAGCCAAAGTCACCATCGTGGACCAC
CACGCCGCCACGGCCTCTTTCATGAAGCACCTGGAGAATGAGCAGAAGGCCAGGGGGGGC
TGCCCTGCAGACTGGGCCTGGATCGTGCCCCCCATCTCGGGCAGCCTCACTCCTGTTTTC
CATCAGGAGATGGTCAACTATTTCCTGTCCCCGGCCTTCCGCTACCAGCCAGACCCCTGG
AAGGGGAGTGCCGCCAAGGGCACCGGCATCACCAGGAAGAAGACCTTTAAAGAAGTGGCC
AACGCCGTGAAGATCTCCGCCTCGCTCATGGGCACGGTGATGGCGAAGCGAGTGAAGGCG
ACAATCCTGTATGGCTCCGAGACCGGCCGGGCCCAGAGCTACGCACAGCAGCTGGGGAGA
CTCTTCCGGAAGGCTTTTGATCCCCGGGTCCTGTGTATGGATGAGTATGACGTGGTGTCC
CTCGAACACGAGACGCTGGTGCTGGTGGTAACCAGCACATTTGGGAATGGGGATCCCCCG
GAGAATGGAGAGAGCTTTGCAGCTGCCCTGATGGAGATGTCCGGCCCCTACAACAGCTCC
CCTCGGCCGGAACAGCACAAGAGTTATAAGATCCGCTTCAACAGCATCTCCTGCTCAGAC
CCACTGGTGTCCTCTTGGCGGCGGAAGAGGAAGGAGTCCAGTAACACAGACAGTGCAGGG
GCCCTGGGCACCCTCAGGTTCTGTGTGTTCGGGCTCGGCTCCCGGGCATACCCCCACTTC
TGCGCCTTTGCTCGTGCCGTGGACACACGGCTGGAGGAACTGGGCGGGGAGCGGCTGCTG
CAGCTGGGCCAGGGCGACGAGCTGTGCGGCCAGGAGGAGGCCTTCCGAGGCTGGGCCCAG
GCTGCCTTCCAGGCCGCCTGTGAGACCTTCTGTGTGGGAGAGGATGCCAAGGCCGCCGCC
CGAGACATCTTCAGCCCCAAACGGAGCTGGAAGCGCCAGAGGTACCGGCTGAGCGCCCAG
GCCGAGGGCCTGCAGTTGCTGCCAGGTCTGATCCACGTGCACAGGCGGAAGATGTTCCAG
GCTACAATCCGCTCAGTGGAAAACCTGCAAAGCAGCAAGTCCACGAGGGCCACCATCCTG
GTGCGCCTGGACACCGGAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACCACATAGGT
GTCTGCCCGCCCAACCGGCCCGGCCTTGTGGAGGCGCTGCTGAGCCGCGTGGAGGACCCG
CCGGCGCCCACTGAGCCCGTGGCAGTAGAGCAGCTGGAGAAGGGCAGCCCTGGTGGCCCT
CCCCCCGGCTGGGTGCGGGACCCCCGGCTGCCCCCGTGCACGCTGCGCCAGGCTCTCACC
TTCTTCCTGGACATCACCTCCCCACCCAGCCCTCAGCTCTTGCGGCTGCTCAGCACCTTG
GCAGAAGAGCCCAGGGAACAGCAGGAGCTGGAGGCCCTCAGCCAGGATCCCCGACGCTAC
GAGGAGTGGAAGTGGTTCCGCTGCCCCACGCTGCTGGAGGTGCTGGAGCAGTTCCCGTCG
GTGGCGCTGCCTGCCCCACTGCTCCTCACCCAGCTGCCTCTGCTCCAGCCCCGGTACTAC
TCAGTCAGCTCGGCACCCAGCACCCACCCAGGAGAGATCCACCTCACTGTAGCTGTGCTG
GCATACAGGACTCAGGATGGGCTGGGCCCCCTGCACTATGGAGTCTGCTCCACGTGGCTA
AGCCAGCTCAAGCCCGGAGACCCTGTGCCCTGCTTCATCCGGGGGGCTCCCTCCTTCCGG
CTGCCACCCGATCCCAGCTTGCCCTGCATCCTGGTGGGTCCAGGCACTGGCATTGCCCCC
TTCCGGGGATTCTGGCAGGAGCGGCTGCATGACATTGAGAGCAAAGGGCTGCAGCCCACT
CCCATGACTTTGGTGTTCGGCTGCCGATGCTCCCAACTTGACCATCTCTACCGCGACGAG
GTGCAGAACGCCCAGCAGCGCGGGGTGTTTGGCCGAGTCCTCACCGCCTTCTCCCGGGAA
CCTGACAACCCCAAGACCTACGTGCAGGACATCCTGAGGACGGAGCTGGCTGCGGAGGTG
CACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTTACCATGGCA
ACCAACGTCCTGCAGACCGTGCAGCGCATCCTGGCGACGGAGGGCGACATGGAGCTGGAC
GAGGCCGGCGACGTCATCGGCGTGCTGCGGGATCAGCAACGCTACCACGAAGACATTTTC
GGGCTCACGCTGCGCACCCAGGAGGTGACAAGCCGCATACGCACCCAGAGCTTTTCCTTG
CAGGAGCGTCAGTTGCGGGGCGCAGTGCCCTGGGCGTTCGACCCTCCCGGCTCAGACACC
AACAGCCCCTGA
Target 1 GenBank Gene ID
Target 1 GeneCard ID NOS3 Link Image
Target 1 GenAtlas ID NOS3 Link Image
Target 1 HGNC ID HGNC:7876 Link Image
Target 1 Chromosome Location 7
Target 1 Locus 7q36
Target 1 SNPs SNPJam Report Link Image
Target 1 General References
  1. Fischmann TO, Hruza A, Niu XD, Fossetta JD, Lunn CA, Dolphin E, Prongay AJ, Reichert P, Lundell DJ, Narula SK, Weber PC: Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation. Nat Struct Biol. 1999 Mar;6(3):233-42. [PubMed Link Image]
  2. Rosenfeld RJ, Garcin ED, Panda K, Andersson G, Aberg A, Wallace AV, Morris GM, Olson AJ, Stuehr DJ, Tainer JA, Getzoff ED: Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency. Biochemistry. 2002 Nov 26;41(47):13915-25. [PubMed Link Image]
  3. Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD: Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem. 1992 Jul 25;267(21):14519-22. [PubMed Link Image]
  4. Marsden PA, Schappert KT, Chen HS, Flowers M, Sundell CL, Wilcox JN, Lamas S, Michel T: Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett. 1992 Aug 3;307(3):287-93. [PubMed Link Image]
  5. Sase K, Michel T: Expression of constitutive endothelial nitric oxide synthase in human blood platelets. Life Sci. 1995;57(22):2049-55. [PubMed Link Image]
  6. Nadaud S, Bonnardeaux A, Lathrop M, Soubrier F: Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene. Biochem Biophys Res Commun. 1994 Feb 15;198(3):1027-33. [PubMed Link Image]
  7. Robinson LJ, Weremowicz S, Morton CC, Michel T: Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene. Genomics. 1994 Jan 15;19(2):350-7. [PubMed Link Image]
  8. Miyahara K, Kawamoto T, Sase K, Yui Y, Toda K, Yang LX, Hattori R, Aoyama T, Yamamoto Y, Doi Y, et al.: Cloning and structural characterization of the human endothelial nitric-oxide-synthase gene. Eur J Biochem. 1994 Aug 1;223(3):719-26. [PubMed Link Image]
  9. Marsden PA, Heng HH, Scherer SW, Stewart RJ, Hall AV, Shi XM, Tsui LC, Schappert KT: Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem. 1993 Aug 15;268(23):17478-88. [PubMed Link Image]
  10. Yoshimura M, Yasue H, Nakayama M, Shimasaki Y, Sumida H, Sugiyama S, Kugiyama K, Ogawa H, Ogawa Y, Saito Y, Miyamoto Y, Nakao K: A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. Hum Genet. 1998 Jul;103(1):65-9. [PubMed Link Image]
Target 1 Drug References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed Link Image]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed Link Image]
Drug Target 2 [top]
Target 2 ID 756
Target 2 Name Sex hormone-binding globulin
Target 2 Synonyms
  1. ABP
  2. SBP
  3. SHBG
  4. Sex hormone-binding globulin precursor
  5. Sex steroid-binding protein
  6. TeBG
  7. Testis-specific androgen-binding protein
  8. Testosterone-estradiol- binding globulin
  9. Testosterone-estrogen-binding globulin
Target 2 Gene Name SHBG
Target 2 Protein Sequence >Sex hormone-binding globulin precursor 
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMT
FDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGA
GPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPAS
NLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDI
PQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPL
VLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTS
FCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH
Target 2 Number of Residues 408
Target 2 Molecular Weight 43780
Target 2 Theoretical pI 6.70
Target 2 GO Classification Not Available
Target 2 General Function Involved in androgen binding
Target 2 Specific Function Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration
Target 2 Pathways Not Available
Target 2 Reactions Not Available
Target 2 Pfam Domain Function
Target 2 Signals
  • 1-29
Target 2 Transmembrane Regions
  • None
Target 2 Essentiality Non-Essential
Target 2 GenBank ID Protein 296673 Link Image
Target 2 UniProtKB/Swiss-Prot ID P04278 Link Image
Target 2 UniProtKB/Swiss-Prot Entry Name SHBG_HUMAN Link Image
Target 2 PDB ID 1F5F Link Image
Target 2 PDB File Show
Target 2 3D Structure
Target 2 Cellular Location
  • Secreted protein. In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the
Target 2 Gene Sequence >1209 bp 
ATGGAGAGCAGAGGCCCACTGGCTACCTCGCGCCTGCTGCTGTTGCTGCTGTTGCTACTA
CTGCGTCACACCCGCCAGGGATGGGCCCTGAGACCTGTTCTCCCCACCCAGAGTGCCCAC
GACCCTCCGGCTGTCCACCTCAGCAATGGCCCAGGACAAGAGCCTATCGCTGTCATGACC
TTTGACCTCACCAAGATCACAAAAACCTCCTCCTCCTTTGAGGTTCGAACCTGGGACCCA
GAGGGAGTGATTTTTTATGGGGATACCAACCCTAAGGATGACTGGTTTATGCTGGGACTT
CGAGACGGCAGGCCTGAGATCCAACTGCACAATCACTGGGCCCAGCTTACGGTGGGTGCT
GGACCACGGCTGGATGATGGGAGATGGCACCAGGTGGAAGTCAAGATGGAGGGGGACTCT
GTGCTGCTGGAGGTGGATGGGGAGGAGGTGCTGCGCCTGAGACAGGTCTCTGGGCCCCTG
ACCAGCAAACGCCATCCCATCATGAGGATTGCGCTTGGGGGGCTGCTCTTCCCCGCTTCC
AACCTTCGGTTGCCGCTGGTTCCTGCCCTGGATGGCTGCCTGCGCCGGGATTCCTGGCTG
GACAAACAGGCCGAGATCTCAGCATCTGCCCCCACTAGCCTCAGAAGCTGTGATGTAGAA
TCAAATCCCGGGATATTTCTCCCTCCAGGGACTCAGGCAGAATTCAATCTCCGAGACATT
CCCCAGCCTCATGCAGAGCCCTGGGCCTTCTCTTTGGACCTGGGACTCAAGCAGGCAGCA
GGCTCAGGCCACCTCCTTGCTCTTGGGACACCAGAGAACCCATCTTGGCTCAGTCTCCAC
CTCCAAGATCAAAAGGTGGTGTTGTCTTCTGGGTCGGGGCCAGGGCTGGATCTGCCCCTG
GTCTTGGGACTCCCTCTTCAGCTGAAGCTGAGTATGTCCAGGGTGGTCTTGAGCCAAGGG
TCGAAGATGAAGGCCCTTGCCCTGCCTCCCTTAGGCCTGGCTCCCCTCCTTAACCTCTGG
GCCAAGCCTCAAGGGCGTCTCTTCCTGGGGGCTTTACCAGGAGAAGACTCTTCCACCTCT
TTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAAC
AGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCCAGGCAATGGCACTGACGCT
TCCCATTAA
Target 2 GenBank Gene ID
Target 2 GeneCard ID SHBG Link Image
Target 2 GenAtlas ID SHBG Link Image
Target 2 HGNC ID HGNC:10839 Link Image
Target 2 Chromosome Location 17
Target 2 Locus 17p13-p12
Target 2 SNPs SNPJam Report Link Image
Target 2 General References
  1. Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES: Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet. 1999 Jul;22(3):231-8. [PubMed Link Image]
  2. Grishkovskaya I, Avvakumov GV, Sklenar G, Dales D, Hammond GL, Muller YA: Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain. EMBO J. 2000 Feb 15;19(4):504-12. [PubMed Link Image]
  3. Grishkovskaya I, Avvakumov GV, Hammond GL, Catalano MG, Muller YA: Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation. J Biol Chem. 2002 Aug 30;277(35):32086-93. Epub 2002 Jun 13. [PubMed Link Image]
  4. Power SG, Bocchinfuso WP, Pallesen M, Warmels-Rodenhiser S, Van Baelen H, Hammond GL: Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain. J Clin Endocrinol Metab. 1992 Oct;75(4):1066-70. [PubMed Link Image]
  5. Gershagen S, Lundwall A, Fernlund P: Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis. Nucleic Acids Res. 1989 Nov 25;17(22):9245-58. [PubMed Link Image]
  6. Hammond GL, Underhill DA, Rykse HM, Smith CL: The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs. Mol Endocrinol. 1989 Nov;3(11):1869-76. [PubMed Link Image]
  7. Que BG, Petra PH: Characterization of a cDNA coding for sex steroid-binding protein of human plasma. FEBS Lett. 1987 Jul 27;219(2):405-9. [PubMed Link Image]
  8. Gershagen S, Fernlund P, Lundwall A: A cDNA coding for human sex hormone binding globulin. Homology to vitamin K-dependent protein S. FEBS Lett. 1987 Aug 10;220(1):129-35. [PubMed Link Image]
  9. Walsh KA, Titani K, Takio K, Kumar S, Hayes R, Petra PH: Amino acid sequence of the sex steroid binding protein of human blood plasma. Biochemistry. 1986 Nov 18;25(23):7584-90. [PubMed Link Image]
  10. Hammond GL, Underhill DA, Smith CL, Goping IS, Harley MJ, Musto NA, Cheng CY, Bardin CW: The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain. FEBS Lett. 1987 May 4;215(1):100-4. [PubMed Link Image]
  11. 3702459 Hammond GL, Robinson PA, Sugino H, Ward DN, Finne J: Physicochemical characteristics of human sex hormone binding globulin: evidence for two identical subunits. J Steroid Biochem. 1986 Apr;24(4):815-24.
  12. 7714097 Hardy DO, Carino C, Catterall JF, Larrea F: Molecular characterization of a genetic variant of the steroid hormone-binding globulin gene in heterozygous subjects. J Clin Endocrinol Metab. 1995 Apr;80(4):1253-6.
Target 2 Drug References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed Link Image]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed Link Image]
Drug Target 3 [top]
Target 3 ID 2512
Target 3 Name Glutathione S-transferase A2
Target 3 Synonyms
  1. EC 2.5.1.18
  2. GST class-alpha member 2
  3. Glutathione S-transferase GT41A
Target 3 Gene Name Gsta2
Target 3 Protein Sequence >Glutathione S-transferase A2 
MAGKPVLHYFNARGRMECIRWLLAAAGVEFEEKFIQSPEDLEKLKKDGNLMFDQVPMVEI
DGMKLVQTRAILNYIATKYDLYGKDMKERALIDMYTEGILDLTEMIGQLVLCPPDQREAK
TALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDVHLLELLLYVEELDASLLTPFPL
LKAFKSRISSLPNVKKFLQPGSQRKPPLDAKQIEEARKVFKF
Target 3 Number of Residues 225
Target 3 Molecular Weight 25533
Target 3 Theoretical pI 9.22
Target 3 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 3 General Function Involved in glutathione transferase activity
Target 3 Specific Function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 3 Pathways
Name SMPDB Link KEGG Link
Glutathione metabolism SMP00015 Link Image map00480 Link Image
Target 3 Reactions
  • RX + glutathione = HX + R-S-glutathione
Target 3 Pfam Domain Function
Target 3 Signals
  • None
Target 3 Transmembrane Regions
  • None
Target 3 Essentiality Essential
Target 3 GenBank ID Protein 309279 Link Image
Target 3 UniProtKB/Swiss-Prot ID P10648 Link Image
Target 3 UniProtKB/Swiss-Prot Entry Name GSTA2_MOUSE Link Image
Target 3 PDB ID 1ML6 Link Image
Target 3 PDB File Show
Target 3 3D Structure
Target 3 Cellular Location Not Available
Target 3 Gene Sequence >669 bp 
ATGGCCGGGAAGCCCGTGCTTCACTACTTCAATGCCCGGGGCAGAATGGAGTGCATCAGG
TGGCTCCTGGCTGCAGCAGGGGTGGAGTTTGAAGAGAAGTTTATACAGAGTCCGGAAGAT
TTGGAAAAGCTAAAAAAAGATGGGAATTTGATGTTTGACCAAGTGCCCATGGTGGAGATT
GATGGGATGAAGCTGGTGCAGACCAGAGCCATTCTCAACTACATCGCCACCAAATATGAC
CTCTATGGGAAGGACATGAAGGAGAGAGCCCTGATTGACATGTATACAGAAGGTATTTTA
GATCTGACTGAAATGATTGGGCAATTGGTATTATGTCCCCCAGACCAAAGAGAAGCCAAG
ACTGCCTTGGCAAAAGACAGGACCAAAAACCGTTACTTGCCTGCCTTTGAAAAGGTGTTG
AAGAGCCATGGACAAGACTACCTTGTGGGCAACAGGCTGACCAGGGTGGACGTCCACCTG
CTGGAACTTCTTCTCTATGTTGAAGAGCTTGATGCCAGCCTTCTGACCCCTTTCCCTCTG
CTGAAGGCCTTCAAGAGCAGAATCAGCAGCCTCCCCAATGTGAAGAAGTTCCTACAGCCT
GGCAGCCAGAGAAAGCCTCCCTTGGATGCAAAACAAATTGAAGAAGCAAGGAAGGTTTTC
AAGTTTTAG
Target 3 GenBank Gene ID
Target 3 GeneCard ID Not Available
Target 3 GenAtlas ID Not Available
Target 3 HGNC ID Not Available
Target 3 Chromosome Location Not Available
Target 3 Locus Not Available
Target 3 SNPs SNPJam Report Link Image
Target 3 General References
  1. Pearson WR, Reinhart J, Sisk SC, Anderson KS, Adler PN: Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole. J Biol Chem. 1988 Sep 15;263(26):13324-32. [PubMed Link Image]
Target 3 Drug References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed Link Image]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed Link Image]
Drug Target 4 [top]
Target 4 ID 2758
Target 4 Name Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Target 4 Synonyms
  1. 7,8-diamino-pelargonic acid aminotransferase
  2. DAPA aminotransferase
  3. EC 2.6.1.62
Target 4 Gene Name bioA
Target 4 Protein Sequence >Adenosylmethionine-8-amino-7-oxononanoate aminotransferase 
MTTDDLAFDQRHIWHPYTSMTSPLPVYPVVSAEGCELILSDGRRLVDGMSSWWAAIHGYN
HPQLNAAMKSQIDAMSHVMFGGITHAPAIELCRKLVAMTPQPLECVFLADSGSVAVEVAM
KMALQYWQAKGEARQRFLTFRNGYHGDTFGAMSVCDPDNSMHSLWKGYLPENLFAPAPQS
RMDGEWDERDMVGFARLMAAHRHEIAAVIIEPIVQGAGGMRMYHPEWLKRIRKICDREGI
LLIADEIATGFGRTGKLFACEHAEIAPDILCLGKALTGGTMTLSATLTTREVAETISNGE
AGCFMHGPTFMGNPLACAAANASLAILESGDWQQQVADIEVQLREQLAPARDAEMVADVR
VLGAIGVVETTHPVNMAALQKFFVEQGVWIRPFGKLIYLMPPYIILPQQLQRLTAAVNRA
VQDETFFCQ
Target 4 Number of Residues 436
Target 4 Molecular Weight 47336
Target 4 Theoretical pI 5.71
Target 4 GO Classification
Function
adenosylmethionine-8-amino-7-oxononanoate transaminase activity
binding
vitamin binding
pyridoxal phosphate binding
catalytic activity
transferase activity
transferase activity, transferring nitrogenous groups
transaminase activity
Process
physiological process
metabolism
cellular metabolism
vitamin metabolism
water-soluble vitamin metabolism
biotin metabolism
biotin biosynthesis
Component
Not Available
Target 4 General Function Coenzyme transport and metabolism
Target 4 Specific Function S-adenosyl-L-methionine + 8-amino-7- oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8- diaminononanoate
Target 4 Pathways
Name SMPDB Link KEGG Link
Biotin metabolism SMP00066 Link Image map00780 Link Image
Target 4 Reactions
  • S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
Target 4 Pfam Domain Function
Target 4 Signals
  • None
Target 4 Transmembrane Regions
  • None
Target 4 Essentiality Essential
Target 4 GenBank ID Protein 457106 Link Image
Target 4 UniProtKB/Swiss-Prot ID P12995 Link Image
Target 4 UniProtKB/Swiss-Prot Entry Name BIOA_ECOLI Link Image
Target 4 PDB ID 1QJ5 Link Image
Target 4 PDB File Show
Target 4 3D Structure
Target 4 Cellular Location
  • Cytoplasm
Target 4 Gene Sequence >1293 bp 
TTATTGGCAAAAAAATGTTTCATCCTGTACCGCGCGGTTAACCGCTGCGGTCAGACGCTG
CAACTGTTGCGGGAGAATAATATAGGGCGGCATCAGGTAAATCAGTTTGCCAAAAGGCCG
GATCCAGACACCCTGTTCGACAAAGAATTTTTGCAGCGCCGCCATATTCACCGGATGAGT
GGTTTCGACCACGCCAATGGCCCCCAGTACGCGCACATCGGCAACCATTTCGGCATCACG
GGCGGGGGCAAGTTGCTCGCGCAGCTGTACTTCAATATCCGCCACCTGTTGCTGCCAGTC
GCCAGATTCGAGAATCGCCAGGCTGGCGTTTGCTGCCGCGCAGGCCAGCGGATTGCCCAT
AAAAGTTGGCCCATGCATAAAGCAACCGGCTTCACCGTTACTGATGGTTTCTGCAACCTC
GCGCGTGGTGAGTGTGGCGGAAAGGGTCATTGTGCCGCCGGTTAAGGCTTTACCGAGGCA
CAAAATGTCCGGCGCGATTTCTGCATGTTCACAGGCAAACAGTTTCCCGGTACGACCAAA
TCCAGTGGCGATCTCGTCGGCAATCAGCAAGATACCTTCGCGATCGCATATTTTGCGGAT
TCGTTTTAACCATTCCGGATGGTACATGCGCATCCCGCCTGCGCCCTGGACAATCGGCTC
AATGATCACCGCCGCGATTTCATGACGATGCGCCGCCATCAGGCGGGCAAAGCCCACCAT
ATCGCGCTCATCCCATTCGCCATCCATGCGGCTTTGCGGGGCGGGAGCAAACAGGTTTTC
TGGCAGGTAGCCTTTCCACAGACTGTGCATTGAGTTATCCGGATCGCACACCGACATCGC
GCCAAAGGTATCGCCATGATAACCATTGCGGAAGGTCAGAAAACGCTGGCGCGCTTCGCC
TTTGGCTTGCCAGTACTGCAACGCCATTTTCATCGCCACTTCCACCGCTACGGAACCGGA
GTCCGCGAGAAAAACGCACTCCAGCGCGTTGCGGCCGCTCATCGCCACCAGTTTGCGGCA
CAGCTCAATGGCTGGCGCATGGGTGATACCGCCAAACATCACATGCGACATGGCATCAAT
TTGCGACTTCATCGCCGCATTAAGCTGCGGGTGATTGTAGCCGTGGATCGCCGCCCACCA
GGACGACATACCGTCAACCAGGCGTCTGCCGTCAGACAAAATCAGCTCGCAACCTTCGGC
GCTCACCACCGGATAAACCGGCAGAGGGGAGGTCATGGATGTGTATGGGTGCCAGATATG
GCGTTGGTCAAAGGCAAGATCGTCCGTTGTCAT
Target 4 GenBank Gene ID
Target 4 GeneCard ID Not Available
Target 4 GenAtlas ID Not Available
Target 4 HGNC ID Not Available
Target 4 Chromosome Location Not Available
Target 4 Locus Not Available
Target 4 SNPs SNPJam Report Link Image
Target 4 General References
  1. Kack H, Sandmark J, Gibson K, Schneider G, Lindqvist Y: Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5'-phosphate-dependent enzymes. J Mol Biol. 1999 Aug 27;291(4):857-76. [PubMed Link Image]
  2. Otsuka AJ, Buoncristiani MR, Howard PK, Flamm J, Johnson C, Yamamoto R, Uchida K, Cook C, Ruppert J, Matsuzaki J: The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon. J Biol Chem. 1988 Dec 25;263(36):19577-85. [PubMed Link Image]
  3. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-74. [PubMed Link Image]
Target 4 Drug References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed Link Image]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed Link Image]
Drug Target 5 [top]
Target 5 ID 2773
Target 5 Name GTPase HRas
Target 5 Synonyms
  1. GTPase HRas precursor
  2. H-Ras-1
  3. Transforming protein p21
  4. c-H-ras
  5. p21ras
Target 5 Gene Name Hras1
Target 5 Protein Sequence >GTPase HRas precursor 
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGLG
CMSCKCVLS
Target 5 Number of Residues 192
Target 5 Molecular Weight 21314
Target 5 Theoretical pI 4.94
Target 5 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
guanyl nucleotide binding
GTP binding
Process
cellular process
cell communication
signal transduction
intracellular signaling cascade
small GTPase mediated signal transduction
Component
Not Available
Target 5 General Function Involved in GTP binding
Target 5 Specific Function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
Target 5 Pathways Not Available
Target 5 Reactions Not Available
Target 5 Pfam Domain Function
Target 5 Signals
  • None
Target 5 Transmembrane Regions
  • None
Target 5 Essentiality Essential
Target 5 GenBank ID Protein 206559 Link Image
Target 5 UniProtKB/Swiss-Prot ID P20171 Link Image
Target 5 UniProtKB/Swiss-Prot Entry Name RASH_RAT Link Image
Target 5 PDB ID 4Q21 Link Image
Target 5 PDB File Show
Target 5 3D Structure
Target 5 Cellular Location
  • Cell membrane
  • Golgi apparatus membrane
  • cytoplasmic side. Golgi apparatus
  • lipid-anch
  • lipid-anchor
Target 5 Gene Sequence >570 bp 
ATGACAGAATACAAGCTTGTGGTGGTGGGCGCTGGAGGCGTGGGAAAGAGTGCCCTGACC
ATCCAGCTGATCCAGAACCATTTTGTGGACGAGTATGATCCCACTATAGAGGACTCCTAC
CGGAAACAGGTAGTCATTGATGGGGAGACGTGTTTACTGGACATCTTAGACACAGCAGGT
CAAGAAGAGTATAGTGCCATGCGGGACCAGTACATGCGCACAGGGGAGGGCTTCCTCTGT
GTATTTGCCATCAACAACACCAAGTCCTTTGAAGACATCCATCAGTACAGGGAGCAGATC
AAGCGGGTGAAAGATTCAGATGATGTGCCAATGGTGCTGGTGGGCAACAAGTGTGACCTG
GCTGCTCGCACTGTTGAGTCTCGGCAGGCCCAGGACCTTGCTCGCAGCTATGGCATCCCC
TACATTGAAACATCAGCCAAGACCCGGCAGGGTGTGGAGGATGCCTTCTACACACTAGTA
CGTGAGATTCGGCAGCATAAACTGCGGAAACTGAACCCGCCTGATGAGAGTGGCCTTGGC
TGCATGAGCTGCAAGTGTGTGCTGTCCTGA
Target 5 GenBank Gene ID
Target 5 GeneCard ID Not Available
Target 5 GenAtlas ID Not Available
Target 5 HGNC ID Not Available
Target 5 Chromosome Location Not Available
Target 5 Locus Not Available
Target 5 SNPs SNPJam Report Link Image
Target 5 General References
  1. Kelley GG, Reks SE, Ondrako JM, Smrcka AV: Phospholipase C(epsilon): a novel Ras effector. EMBO J. 2001 Feb 15;20(4):743-54. [PubMed Link Image]
  2. Ruta M, Wolford R, Dhar R, Defeo-Jones D, Ellis RW, Scolnick EM: Nucleotide sequence of the two rat cellular rasH genes. Mol Cell Biol. 1986 May;6(5):1706-10. [PubMed Link Image]
  3. Clarke S, Vogel JP, Deschenes RJ, Stock J: Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4643-7. [PubMed Link Image]
Target 5 Drug References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed Link Image]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed Link Image]
Drug Target 6 [top]
Target 6 ID 2907
Target 6 Name Oxysterols receptor LXR-beta
Target 6 Synonyms
  1. Liver X receptor beta
  2. Nuclear orphan receptor LXR-beta
  3. Nuclear receptor NER
  4. Ubiquitously-expressed nuclear receptor
Target 6 Gene Name NR1H2
Target 6 Protein Sequence >Oxysterols receptor LXR-beta 
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS
QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK
RSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ
IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAM
RRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPR
MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Target 6 Number of Residues 468
Target 6 Molecular Weight 51102
Target 6 Theoretical pI 7.80
Target 6 GO Classification
Function
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 6 General Function Involved in transcription factor activity
Target 6 Specific Function Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4)
Target 6 Pathways Not Available
Target 6 Reactions Not Available
Target 6 Pfam Domain Function
Target 6 Signals
  • None
Target 6 Transmembrane Regions
  • None
Target 6 Essentiality Non-Essential
Target 6 GenBank ID Protein 641962 Link Image
Target 6 UniProtKB/Swiss-Prot ID P55055 Link Image
Target 6 UniProtKB/Swiss-Prot Entry Name NR1H2_HUMAN Link Image
Target 6 PDB ID 1UPW Link Image
Target 6 PDB File Show
Target 6 3D Structure
Target 6 Cellular Location
  • Nucleus (Potential)
Target 6 Gene Sequence >1386 bp 
ATGTCCTCTCCTACCACGAGTTCCCTGGATACCCCCCTGCCTGGAAATGGCCCCCCTCAG
CCTGGCGCCCCTTCTTCTTCACCCACTGTAAAGGAGGAGGGTCCGGAGCCGTGGCCCGGG
GGTCCGGACCCTGATGTCCCAGGCACTGATGAGGCCAGCTCAGCCTGCAGCACAGACTGG
GTCATCCCAGATCCCGAAGAGGAACCAGAGCGCAAGCGAAAGAAGGGCCCAGCCCCGAAG
ATGCTGGGCCACGAGCTTTGCCGTGTCTGTGGGGACAAGGCCTCCGGCTTCCACTACAAC
GTGCTCAGCTGCGAAGGCTGCAAGGGCTTCTTCCGGCGCAGTGTGGTCCGTGGTGGGGCC
AGGCGCTATGCCTGCCGGGGTGGCGGAACCTGCCAGATGGACGCTTTCATGCGGCGCAAG
TGCCAGCAGTGCCGGCTGCGCAAGTGCAAGGAGGCAGGGATGAGGGAGCAGTGCGTCCTT
TCTGAAGAACAGATCCGGAAGAAGAAGATTCGGAAACAGCAGCAGCAGGAGTCACAGTCA
CAGTCGCAGTCACCTGTGGGGCCGCAGGGCAGCAGCAGCTCAGCCTCTGGGCCTGGGGCT
TCCCCTGGTGGATCTGAGGCAGGCAGCCAGGGCTCCGGGGAAGGCGAGGGTGTCCAGCTA
ACAGCGGCTCAAGAACTAATGATCCAGCAGTTGGTGGCGGCCCAACTGCAGTGCAACAAA
CGCTCCTTCTCCGACCAGCCCAAAGTCACGCCCTGGCCCCTGGGCGCAGACCCCCAGTCC
CGAGATGCCCGCCAGCAACGCTTTGCCCACTTCACGGAGCTGGCCATCATCTCAGTCCAG
GAGATCGTGGACTTCGCTAAGCAAGTGCCTGGTTTCCTGCAGCTGGGCCGGGAGGACCAG
ATCGCCCTCCTGAAGGCATCCACTATCGAGATCATGCTGCTAGAGACAGCCAGGCGCTAC
AACCACGAGACAGAGTGTATCACCTTCTTGAAGGACTTCACCTACAGCAAGGACGACTTC
CACCGTGCAGGCCTGCAGGTGGAGTTCATCAACCCCATCTTCGAGTTCTCGCGGGCCATG
CGGCGGCTGGGCCTGGACGACGCTGAGTACGCCCTGCTCATCGCCATCAACATCTTCTCG
GCCGACCGGCCCAACGTGCAGGAGCCGGGCCGCGTGGAGGCGTTGCAGCAGCCCTACGTG
GAGGCGCTGCTGTCCTACACGCGCATCAAGAGGCCGCAGGACCAGCTGCGCTTCCCGCGC
ATGCTCATGAAGCTGGTGAGCCTGCGCACGCTGAGCTCTGTGCACTCGGAGCAGGTCTTC
GCCTTGCGGCTCCAGGACAAGAAGCTGCCGCCTCTGCTGTCGGAGATCTGGGACGTCCAC
GAGTGA
Target 6 GenBank Gene ID
Target 6 GeneCard ID NR1H2 Link Image
Target 6 GenAtlas ID NR1H2 Link Image
Target 6 HGNC ID HGNC:7965 Link Image
Target 6 Chromosome Location 19
Target 6 Locus 19q13.3-19q13.3
Target 6 SNPs SNPJam Report Link Image
Target 6 General References
  1. Shinar DM, Endo N, Rutledge SJ, Vogel R, Rodan GA, Schmidt A: NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. Gene. 1994 Sep 30;147(2):273-6. [PubMed Link Image]
Target 6 Drug References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed Link Image]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed Link Image]
Drug Target 7 [top]
Target 7 ID 3040
Target 7 Name Putative 1-aminocyclopropane-1-carboxylate deaminase
Target 7 Synonyms
  1. ACC deaminase
  2. EC 3.5.99.7
Target 7 Gene Name Not Available
Target 7 Protein Sequence >Putative 1-aminocyclopropane-1-carboxylate deaminase 
MHPKIFALLAKFPRVELIPWETPIQYLPNISREIGADVYIKRDDLTGLGIGGNKIRKLEY
LLGDALSKGADVVITVGAVHSNHAFVTGLAAKKLGLDAILVLRGKEELKGNYLLDKIMGI
ETRVYDAKDSFELMKYAEEIAEELKREGRKPYVIPPGGASPIGTLGYVRAVGEIATQSEV
KFDSIVVAAGSGGTLAGLSLGLSILNEDIRPVGIAVGRFGEVMTSKLDNLIKEAAELLGV
KVEVRPELYDYSFGEYGKITGEVAQIIRKVGTREGIILDPVYTGKAFYGLVDLARKGELG
EKILFIHTGGISGTFHYGDKLLSLL
Target 7 Number of Residues 330
Target 7 Molecular Weight 35188
Target 7 Theoretical pI 6.70
Target 7 GO Classification
Function
catalytic activity
Process
physiological process
metabolism
Component
Not Available
Target 7 General Function Amino acid transport and metabolism
Target 7 Specific Function 1-aminocyclopropane-1-carboxylate + H(2)O = 2- oxobutanoate + NH(3)
Target 7 Pathways
Name SMPDB Link KEGG Link
Propanoate metabolism SMP00016 Link Image map00640 Link Image
Target 7 Reactions
  • 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3
Target 7 Pfam Domain Function
Target 7 Signals
  • None
Target 7 Transmembrane Regions
  • None
Target 7 Essentiality Essential
Target 7 GenBank ID Protein 3256439 Link Image
Target 7 UniProtKB/Swiss-Prot ID O57809 Link Image
Target 7 UniProtKB/Swiss-Prot Entry Name 1A1D_PYRHO Link Image
Target 7 PDB ID 1J0B Link Image
Target 7 PDB File Show
Target 7 3D Structure
Target 7 Cellular Location Not Available
Target 7 Gene Sequence >987 bp 
CTAAAGTAGTGACAAAAGTTTGTCACCATAGTGGAACGTTCCCGATATCCCTCCAGTATG
GATAAAGAGAATCTTCTCCCCCAACTCCCCTTTCCTAGCTAGATCAACGAGCCCATAGAA
TGCCTTCCCCGTATATACGGGATCCAGTATTATTCCTTCCCTCGTTCCAACTTTCCTTAT
AATTTGAGCAACTTCACCGGTTATCTTACCGTACTCTCCAAAGCTGTAGTCGTATAACTC
CGGCCTTACCTCAACCTTTACTCCAAGTAACTCCGCAGCTTCTTTAATTAAGTTGTCCAG
CTTACTAGTCATTACTTCACCGAATCTACCAACTGCGATTCCTACGGGTCTAATATCTTC
ATTAAGGATCGACAAGCCCAGGGATAATCCTGCAAGCGTACCTCCACTTCCAGCTGCTAC
AACTATGCTATCGAATTTAACTTCGCTCTGCGTTGCAATCTCTCCAACGGCCCTAACGTA
ACCAAGCGTCCCTATTGGGGATGCTCCTCCCGGTGGAATAACATAGGGCTTCCTACCCTC
TCTTTTCAATTCCTCCGCGATCTCCTCAGCATACTTCATGAGCTCAAAGGAGTCCTTTGC
ATCATACACCCTTGTTTCGATGCCCATGATCTTATCTAGAAGGTAGTTTCCTTTCAGCTC
TTCCTTCCCCCTTAAAACTAGGATTGCATCAAGCCCAAGTTTCTTGGCGGCTAGTCCAGT
AACGAATGCATGATTGGAATGCACTGCTCCCACAGTTATTACGACGTCTGCTCCTTTAGA
GAGAGCGTCACCCAGGAGATATTCGAGCTTCCTTATTTTATTCCCCCCAATTCCGAGACC
AGTTAGATCATCCCTTTTGATATATACGTCGGCTCCTATTTCTCTACTTATGTTAGGAAG
GTACTGTATGGGTGTCTCCCAGGGGATTAACTCAACCCTTGGAAATTTAGCAAGAAGAGC
AAAGATCTTCGGATGCATATTCACCAC
Target 7 GenBank Gene ID
Target 7 GeneCard ID Not Available
Target 7 GenAtlas ID Not Available
Target 7 HGNC ID Not Available
Target 7 Chromosome Location Not Available
Target 7 Locus Not Available
Target 7 SNPs Not Available
Target 7 General References
  1. Kawarabayasi Y, Sawada M, Horikawa H, Haikawa Y, Hino Y, Yamamoto S, Sekine M, Baba S, Kosugi H, Hosoyama A, Nagai Y, Sakai M, Ogura K, Otsuka R, Nakazawa H, Takamiya M, Ohfuku Y, Funahashi T, Tanaka T, Kudoh Y, Yamazaki J, Kushida N, Oguchi A, Aoki K, Kikuchi H: Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3. DNA Res. 1998 Apr 30;5(2):55-76. [PubMed Link Image]
Target 7 Drug References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed Link Image]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed Link Image]
Drug Target 8 [top]
Target 8 ID 3103
Target 8 Name ABC transporter ATP-binding protein MJ0796
Target 8 Synonyms Not Available
Target 8 Gene Name Not Available
Target 8 Protein Sequence >ABC transporter ATP-binding protein MJ0796 
MIKLKNVTKTYKMGEEIIYALKNVNLNIKEGEFVSIMGPSGSGKSTMLNIIGCLDKPTEG
EVYIDNIKTNDLDDDELTKIRRDKIGFVFQQFNLIPLLTALENVELPLIFKYRGAMSGEE
RRKRALECLKMAELEERFANHKPNQLSGGQQQRVAIARALANNPPIILADEPTGALDSKT
GEKIMQLLKKLNEEDGKTVVVVTHDINVARFGERIIYLKDGEVEREEKLRGFDDR
Target 8 Number of Residues 238
Target 8 Molecular Weight 26566
Target 8 Theoretical pI 5.96
Target 8 GO Classification
Function
ATPase activity
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
nucleoside-triphosphatase activity
binding
nucleotide binding
Process
Not Available
Component
Not Available
Target 8 General Function Defense mechanisms and drug transport
Target 8 Specific Function Not Available
Target 8 Pathways Not Available
Target 8 Reactions Not Available
Target 8 Pfam Domain Function
Target 8 Signals
  • None
Target 8 Transmembrane Regions
  • None
Target 8 Essentiality Essential
Target 8 GenBank ID Protein 1591493 Link Image
Target 8 UniProtKB/Swiss-Prot ID Q58206 Link Image
Target 8 UniProtKB/Swiss-Prot Entry Name Y796_METJA Link Image
Target 8 PDB ID 1L2T Link Image
Target 8 PDB File Show
Target 8 3D Structure
Target 8 Cellular Location
  • Cytoplasmic
Target 8 Gene Sequence >708 bp 
ATGATTAAACTCAAAAATGTAACAAAAACATACAAAATGGGAGAAGAAATTATTTATGCT
CTAAAAAATGTAAATCTGAATATAAAAGAGGGAGAGTTTGTTTCGATTATGGGTCCTTCT
GGCAGTGGAAAATCAACAATGTTAAATATTATTGGCTGTTTAGACAAACCAACAGAGGGA
GAGGTTTATATTGATAATATAAAGACCAATGACTTAGATGATGATGAATTAACAAAAATT
AGAAGAGATAAAATTGGTTTTGTCTTTCAGCAATTCAACTTAATTCCTTTATTAACTGCC
TTAGAAAATGTTGAACTTCCACTGATTTTTAAATATAGGGGAGCAATGAGCGGAGAAGAG
AGGAGGAAGAGAGCTTTAGAATGCTTAAAGATGGCAGAGTTGGAGGAGAGATTTGCCAAT
CACAAACCAAATCAGTTGAGTGGAGGGCAACAACAGAGAGTTGCTATAGCGAGGGCTTTG
GCAAACAACCCACCAATTATATTGGCGGATGAGCCAACTGGAGCATTAGATAGCAAAACA
GGAGAAAAGATAATGCAATTATTAAAAAAATTAAATGAAGAGGATGGAAAAACCGTTGTT
GTTGTTACCCATGATATAAATGTTGCGAGATTTGGAGAGAGAATAATTTATTTAAAAGAT
GGAGAGGTTGAGAGGGAAGAAAAATTGAGGGGATTTGATGATAGATAA
Target 8 GenBank Gene ID
Target 8 GeneCard ID Not Available
Target 8 GenAtlas ID Not Available
Target 8 HGNC ID Not Available
Target 8 Chromosome Location Not Available
Target 8 Locus Not Available
Target 8 SNPs Not Available
Target 8 General References
  1. Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ, Hunt JF: The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter. J Biol Chem. 2001 Aug 24;276(34):32313-21. Epub 2001 Jun 11. [PubMed Link Image]
  2. Smith PC, Karpowich N, Millen L, Moody JE, Rosen J, Thomas PJ, Hunt JF: ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer. Mol Cell. 2002 Jul;10(1):139-49. [PubMed Link Image]
  3. Bult CJ, White O, Olsen GJ, Zhou L, Fleischmann RD, Sutton GG, Blake JA, FitzGerald LM, Clayton RA, Gocayne JD, Kerlavage AR, Dougherty BA, Tomb JF, Adams MD, Reich CI, Overbeek R, Kirkness EF, Weinstock KG, Merrick JM, Glodek A, Scott JL, Geoghagen NS, Venter JC: Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science. 1996 Aug 23;273(5278):1058-73. [PubMed Link Image]
Target 8 Drug References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed Link Image]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed Link Image]
Drug Target 9 [top]
Target 9 ID 3338
Target 9 Name Small inducible cytokine A20
Target 9 Synonyms
  1. Beta chemokine exodus-1
  2. CC chemokine LARC
  3. CCL20
  4. Liver and activation- regulated chemokine
  5. MIP-3-alpha
  6. Macrophage inflammatory protein 3 alpha
  7. Small inducible cytokine A20 precursor
Target 9 Gene Name CCL20
Target 9 Protein Sequence >Small inducible cytokine A20 precursor 
MCCTKSLLLAALMSVLLLHLCGESEAASNFDCCLGYTDRILHPKFIVGFTRQLANEGCDI
NAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM
Target 9 Number of Residues 97
Target 9 Molecular Weight 10762
Target 9 Theoretical pI 9.17
Target 9 GO Classification
Function
chemokine activity
signal transducer activity
receptor binding
cytokine activity
Process
response to stimulus
response to biotic stimulus
defense response
immune response
Component
extracellular region
Target 9 General Function Involved in cytokine activity
Target 9 Specific Function Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213
Target 9 Pathways Not Available
Target 9 Reactions Not Available
Target 9 Pfam Domain Function
Target 9 Signals
  • 1-26
Target 9 Transmembrane Regions
  • None
Target 9 Essentiality Non-Essential
Target 9 GenBank ID Protein 1790925 Link Image
Target 9 UniProtKB/Swiss-Prot ID P78556 Link Image
Target 9 UniProtKB/Swiss-Prot Entry Name CCL20_HUMAN Link Image
Target 9 PDB ID 1M8A Link Image
Target 9 PDB File Show
Target 9 3D Structure
Target 9 Cellular Location
  • Secreted protein
Target 9 Gene Sequence >291 bp 
ATGTGCTGTACCAAGAGTTTGCTCCTGGCTGCTTTGATGTCAGTGCTGCTACTCCACCTC
TGCGGCGAATCAGAAGCAGCAAGCAACTTTGACTGCTGTCTTGGATACACAGACCGTATT
CTTCATCCTAAATTTATTGTGGGCTTCACACGGCAGCTGGCCAATGAAGGCTGTGACATC
AATGCTATCATCTTTCACACAAAGAAAAAGTTGTCTGTGTGCGCAAATCCAAAACAGACT
TGGGTGAAATATATTGTGCGTCTCCTCAGTAAAAAAGTCAAGAACATGTAA
Target 9 GenBank Gene ID
Target 9 GeneCard ID CCL20 Link Image
Target 9 GenAtlas ID CCL20 Link Image
Target 9 HGNC ID HGNC:10619 Link Image
Target 9 Chromosome Location 2
Target 9 Locus 2q33-q37
Target 9 SNPs SNPJam Report Link Image
Target 9 General References
  1. Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A: Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. J Immunol. 1997 Feb 1;158(3):1033-6. [PubMed Link Image]
  2. Hieshima K, Imai T, Opdenakker G, Van Damme J, Kusuda J, Tei H, Sakaki Y, Takatsuki K, Miura R, Yoshie O, Nomiyama H: Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J Biol Chem. 1997 Feb 28;272(9):5846-53. [PubMed Link Image]
  3. Hromas R, Gray PW, Chantry D, Godiska R, Krathwohl M, Fife K, Bell GI, Takeda J, Aronica S, Gordon M, Cooper S, Broxmeyer HE, Klemsz MJ: Cloning and characterization of exodus, a novel beta-chemokine. Blood. 1997 May 1;89(9):3315-22. [PubMed Link Image]
Target 9 Drug References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed Link Image]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed Link Image]
Drug Target 10 [top]
Target 10 ID 3391
Target 10 Name Heme oxygenase 1
Target 10 Synonyms
  1. EC 1.14.99.3
Target 10 Gene Name pbsA1
Target 10 Protein Sequence >Heme oxygenase 1 
MSVNLASQLREGTKKSHSMAENVGFVKCFLKGVVEKNSYRKLVGNLYFVYSAMEEEMAKF
KDHPILSHIYFPELNRKQSLEQDLQFYYGSNWRQEVKISAAGQAYVDRVRQVAATAPELL
VAHSYTRYLGDLSGGQILKKIAQNAMNLHDGGTAFYEFADIDDEKAFKNTYRQAMNDLPI
DQATAERIVDEANDAFAMNMKMFNELEGNLIKAIGIMVFNSLTRRRSQGSTEVGLATSEG
Target 10 Number of Residues 244
Target 10 Molecular Weight 27051
Target 10 Theoretical pI 6.69
Target 10 GO Classification
Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
heme oxygenase (decyclizing) activity
Process
physiological process
metabolism
cellular metabolism
heterocycle metabolism
porphyrin metabolism
heme metabolism
heme oxidation
Component
Not Available
Target 10 General Function Involved in heme oxygenase (decyclizing) activity
Target 10 Specific Function Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae
Target 10 Pathways
Name SMPDB Link KEGG Link
Porphyrin and chlorophyll metabolism map00860 Link Image
Target 10 Reactions
  • heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O
Target 10 Pfam Domain Function
Target 10 Signals
  • None
Target 10 Transmembrane Regions
  • None
Target 10 Essentiality Essential
Target 10 GenBank ID Protein 1651938 Link Image
Target 10 UniProtKB/Swiss-Prot ID P72849 Link Image
Target 10 UniProtKB/Swiss-Prot Entry Name HO1_SYNY3 Link Image
Target 10 PDB ID 1WE1 Link Image
Target 10 PDB File Show
Target 10 3D Structure
Target 10 Cellular Location Not Available
Target 10 Gene Sequence >723 bp 
CTAGCCTTCGGAGGTGGCGAGGCCAACTTCGGTGCTGCCTTGACTGCGGCGACGGGTGAG
GCTGTTGAACACCATAATGCCGATCGCCTTGATCAGGTTGCCTTCAAGTTCGTTGAACAT
TTTCATGTTCATGGCAAAGGCGTCATTGGCTTCATCCACAATCCGTTCGGCGGTGGCTTG
GTCAATGGGCAGATCATTCATAGCTTGACGGTAGGTATTTTTAAAAGCCTTTTCGTCATC
AATGTCGGCAAATTCATAGAAAGCTGTGCCACCATCGTGGAGATTCATGGCATTTTGGGC
AATTTTCTTGAGAATTTGACCGCCGGAAAGATCCCCCAGGTAACGGGTGTAGGAATGGGC
CACCAACAATTCAGGGGCCGTAGCGGCCACTTGCCGGACTCGGTCCACATAGGCTTGGCC
AGCGGCAGAAATTTTCACTTCTTGCCGCCAGTTGGAGCCGTAATAGAATTGCAGGTCTTG
CTCTAGGCTTTGTTTGCGGTTGAGTTCGGGGAAGTAAATGTGGCTGAGGATGGGATGGTC
CTTAAATTTTGCCATTTCCTCTTCCATGGCACTGTAGACAAAGTAGAGATTGCCAACCAG
CTTACGGTAGGAATTTTTCTCGACAACGCCCTTGAGGAAGCATTTGACAAAGCCGACGTT
CTCCGCCATGGAGTGGGATTTTTTCGTCCCTTCCCGCAACTGGGAAGCTAAGTTGACACT
CAT
Target 10 GenBank Gene ID
Target 10 GeneCard ID Not Available
Target 10 GenAtlas ID Not Available
Target 10 HGNC ID Not Available
Target 10 Chromosome Location Not Available
Target 10 Locus Not Available
Target 10 SNPs SNPJam Report Link Image
Target 10 General References
  1. Kaneko T, Sato S, Kotani H, Tanaka A, Asamizu E, Nakamura Y, Miyajima N, Hirosawa M, Sugiura M, Sasamoto S, Kimura T, Hosouchi T, Matsuno A, Muraki A, Nakazaki N, Naruo K, Okumura S, Shimpo S, Takeuchi C, Wada T, Watanabe A, Yamada M, Yasuda M, Tabata S: Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions. DNA Res. 1996 Jun 30;3(3):109-36. [PubMed Link Image]
Target 10 Drug References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed Link Image]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed Link Image]
Drug Target 11 [top]
Target 11 ID 3777
Target 11 Name ATP-dependent Clp protease ATP-binding subunit clpA
Target 11 Synonyms Not Available
Target 11 Gene Name clpA
Target 11 Protein Sequence >ATP-dependent Clp protease ATP-binding subunit clpA 
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPSAREALEACSVDLVALRQELEA
FIEQTTPVLPASEEERDTQPTLSFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQA
AYLLRKHEVSRLDVVNFISHGTRKDEPTQSSDPGSQPNSEEQAGGEERMENFTTNLNQLA
RVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPEVM
ADCTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTIIGAGAASGGQ
VDAANLIKPLLSSGKIRVIGSTTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIING
LKPKYEAHHDVRYTAKAVRAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRKKT
VNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIEALTEAIKMARAG
LGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFDMSEYMERHTVSRLIGAPPGY
VGFDQGGLLTDAVIKHPHAVLLLDEIEKAHPDVFNILLQVMDNGTLTDNNGRKADFRNVV
LVMTTNAGVRETERKSIGLIHQDNSTDAMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQ
VVDKFIVELQVQLDQKGVSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLANEL
LFGSLVDGGQVTVALDKEKNELTYGFQSAQKHKAEAAH
Target 11 Number of Residues 770
Target 11 Molecular Weight 84208
Target 11 Theoretical pI 6.26
Target 11 GO Classification
Function
protein binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
nucleoside-triphosphatase activity
binding
nucleotide binding
Process
physiological process
metabolism
macromolecule metabolism
protein metabolism
Component
Not Available
Target 11 General Function Posttranslational modification, protein turnover, chaperones
Target 11 Specific Function ATP-dependent specificity component of the clpP protease. It directs the protease to specific substrates. The primary function of the clpA-clpP complex appears to be the degradation of unfolded or abnormal proteins
Target 11 Pathways Not Available
Target 11 Reactions Not Available
Target 11 Pfam Domain Function
Target 11 Signals
  • None
Target 11 Transmembrane Regions
  • None
Target 11 Essentiality Non-Essential
Target 11 GenBank ID Protein Not Available
Target 11 UniProtKB/Swiss-Prot ID P0ABH9 Link Image
Target 11 UniProtKB/Swiss-Prot Entry Name CLPA_ECOLI Link Image
Target 11 PDB ID 1KSF Link Image
Target 11 PDB File Show
Target 11 3D Structure
Target 11 Cellular Location
  • Cytoplasmic
Target 11 Gene Sequence Not Available
Target 11 GenBank Gene ID
Target 11 GeneCard ID Not Available
Target 11 GenAtlas ID Not Available
Target 11 HGNC ID Not Available
Target 11 Chromosome Location Not Available
Target 11 Locus Not Available
Target 11 SNPs SNPJam Report Link Image
Target 11 General References
  1. Guo F, Maurizi MR, Esser L, Xia D: Crystal structure of ClpA, an Hsp100 chaperone and regulator of ClpAP protease. J Biol Chem. 2002 Nov 29;277(48):46743-52. Epub 2002 Aug 29. [PubMed Link Image]
  2. Guo F, Esser L, Singh SK, Maurizi MR, Xia D: Crystal structure of the heterodimeric complex of the adaptor, ClpS, with the N-domain of the AAA+ chaperone, ClpA. J Biol Chem. 2002 Nov 29;277(48):46753-62. Epub 2002 Sep 15. [PubMed Link Image]
  3. Zeth K, Ravelli RB, Paal K, Cusack S, Bukau B, Dougan DA: Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA. Nat Struct Biol. 2002 Dec;9(12):906-11. [PubMed Link Image]
  4. Cummings HS, Sands JF, Foreman PC, Fraser J, Hershey JW: Structure and expression of the infA operon encoding translational initiation factor IF1. Transcriptional control by growth rate. J Biol Chem. 1991 Sep 5;266(25):16491-8. [PubMed Link Image]
  5. Gottesman S, Squires C, Pichersky E, Carrington M, Hobbs M, Mattick JS, Dalrymple B, Kuramitsu H, Shiroza T, Foster T, et al.: Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes. Proc Natl Acad Sci U S A. 1990 May;87(9):3513-7. [PubMed Link Image]
  6. Gottesman S, Clark WP, Maurizi MR: The ATP-dependent Clp protease of Escherichia coli. Sequence of clpA and identification of a Clp-specific substrate. J Biol Chem. 1990 May 15;265(14):7886-93. [PubMed Link Image]
  7. Katayama Y, Gottesman S, Pumphrey J, Rudikoff S, Clark WP, Maurizi MR: The two-component, ATP-dependent Clp protease of Escherichia coli. Purification, cloning, and mutational analysis of the ATP-binding component. J Biol Chem. 1988 Oct 15;263(29):15226-36. [PubMed Link Image]
  8. Oshima T, Aiba H, Baba T, Fujita K, Hayashi K, Honjo A, Ikemoto K, Inada T, Itoh T, Kajihara M, Kanai K, Kashimoto K, Kimura S, Kitagawa M, Makino K, Masuda S, Miki T, Mizobuchi K, Mori H, Motomura K, Nakamura Y, Nashimoto H, Nishio Y, Saito N, Horiuchi T, et al.: A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map. DNA Res. 1996 Jun 30;3(3):137-55. [PubMed Link Image]
  9. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-74. [PubMed Link Image]
Target 11 Drug References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed Link Image]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed Link Image]
Drug Target 12 [top]
Target 12 ID 5421
Target 12 Name Uridine phosphorylase, putative
Target 12 Synonyms
  1. EC 2.4.2.3
Target 12 Gene Name PFE0660c
Target 12 Protein Sequence >Uridine phosphorylase, putative 
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFL
CVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHL
LIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAV
VEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKL
ATKYA
Target 12 Number of Residues 249
Target 12 Molecular Weight 26858
Target 12 Theoretical pI 6.49
Target 12 GO Classification
Function
catalytic activity
Process
physiological process
metabolism
cellular metabolism
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
nucleoside metabolism
Component
Not Available
Target 12 General Function Involved in catalytic activity
Target 12 Specific Function Not Available
Target 12 Pathways Not Available
Target 12 Reactions Not Available
Target 12 Pfam Domain Function
Target 12 Signals
  • None
Target 12 Transmembrane Regions
  • None
Target 12 Essentiality Essential
Target 12 GenBank ID Protein Not Available
Target 12 UniProtKB/Swiss-Prot ID Q8I3X4 Link Image
Target 12 UniProtKB/Swiss-Prot Entry Name Q8I3X4_PLAF7 Link Image
Target 12 PDB ID 1Q1G Link Image
Target 12 PDB File Show
Target 12 3D Structure
Target 12 Cellular Location Not Available
Target 12 Gene Sequence >738 bp 
TTAGGCATATTTGGTTGCTAATTTTGCACATGCTCCTAAGGCTATTTTAATCATATTTTC
TAATTGGTGAGGAACTAAATTGTTGTCGAAATCCCCTTCGTCCCATTTGAATGGACATCC
ATCAACAATAAGAATACCACCTGTTTTAACTTTTCTTAAGGTTCCAATAACCATAAGAGT
GGCTAGTTCCATTTCAACAACAGCAGCATTAGCTTTAGAATAATCTTCTAATCTTGAAGG
AATAATTTTATTGGGATAATACATATCTGATGAAACACTGATACCATTAAAAACTGGCAC
ATTCAATTCTTGTGCACATTTATTTAAAGTATCATAAACATCAAAATCACCAACAGCTGG
GAAATCTCCATGAATTAATAAATGAGATACTCTATCTTCCCTAACAGCTGCATTACATAT
ACATATGTCACCTCTTTTTATTAAATCTGGTTGAAGAGATCCACATGAACCTGCACGAAT
AATTACTTTAGCTCCATTTTGACATAATTCTTCAAAACATACAGCACATCCTGCTGAACC
TACACCGTGACTAACACATAAAAATTTCTGACCCTTATAATGACATTCTACACTTTTGTA
TTCTCTGTTGTATGCTAAATCAACATATGAATCACATACCACTTTTATCTTGTCGACTCT
TCCTGGATCTCCTACAACTAAAACAACTGGTGTTATTTGTTCCTTGCTTATTTTTAAATG
GCGTAAAAGATTATCCAT
Target 12 GenBank Gene ID
Target 12 GeneCard ID Not Available
Target 12 GenAtlas ID Not Available
Target 12 HGNC ID Not Available
Target 12 Chromosome Location Not Available
Target 12 Locus Not Available
Target 12 SNPs SNPJam Report Link Image
Target 12 General References
  1. Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG: Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature. 2002 Oct 3;419(6906):527-31. [PubMed Link Image]
Target 12 Drug References Not Available
Drug Target 13 [top]
Target 13 ID 5659
Target 13 Name Cag-Z
Target 13 Synonyms Not Available
Target 13 Gene Name cag-Z
Target 13 Protein Sequence >Cag-Z 
MELGFNEAERQKILDSNSSLMRNANEVRDKFIQNYATSLKDSNDPQDFLRRVQELRINMQ
KNFISFDAYYNYLNNLVLASYNRCKQEKTFAESTIKNELTLGEFVAEISDNFNNFTCDEV
ARISDLVASYLPREYLPPFIDGNMMGVAFQILGIDDFGKKLNEIVQDIGTKYIILSKNKT
YLTSLERAKLITQLKLNLE
Target 13 Number of Residues 202
Target 13 Molecular Weight 23044
Target 13 Theoretical pI 4.80
Target 13 GO Classification Not Available
Target 13 General Function Not Available
Target 13 Specific Function Not Available
Target 13 Pathways Not Available
Target 13 Reactions Not Available
Target 13 Pfam Domain Function Not Available
Target 13 Signals
  • None
Target 13 Transmembrane Regions
  • None
Target 13 Essentiality Essential
Target 13 GenBank ID Protein Not Available
Target 13 UniProtKB/Swiss-Prot ID Q9JMX9 Link Image
Target 13 UniProtKB/Swiss-Prot Entry Name Q9JMX9_HELPY Link Image
Target 13 PDB ID 1S2X Link Image
Target 13 PDB File Show
Target 13 3D Structure
Target 13 Cellular Location Not Available
Target 13 Gene Sequence >600 bp 
TTATTCCAAATTTAATTTTAATTGGGTTATCAATTTAGCTCTTTCTAAAGAAGTGAGATA
AGTCTTATTTTTGCTCAAAATAATATATTTAGTCCCTATATCTTGGACAATCTCATTGAG
CTTTTTCCCAAAATCATCTATCCCTAGAATCTGAAACGCCACGCCCATCATATTGCCATC
TATGAATGGCGGTAAATACTCTCTTGGCAGATAAGAAGCCACTAGGTCTGAAATTCTTGC
CACTTCATCACACGTAAAATTATTGAAGTTGTCAGAAATTTCTGCAACAAACTCTCCAAG
CGTTAGTTCATTTTTGATCGTGCTTTCTGCAAAAGTCTTTTCTTGTTTGCAACGATTGTA
ACTGGCTAACACAAGGTTGTTTAAATAGTTGTAATAAGCATCAAAACTAATAAAATTCTT
TTGCATATTGATTCTTAACTCTTGAACTCTTCTCAAAAAATCTTGTGGATCGTTGCTATC
TTTTAAAGAAGTGGCGTAATTTTGAATAAACTTATCCCTTACTTCATTCGCATTTCTCAT
AAGAGAACTGTTGCTATCTAAGATCTTTTGTCTTTCTGCTTCATTGAAACCGAGTTCCAT
Target 13 GenBank Gene ID
Target 13 GeneCard ID Not Available
Target 13 GenAtlas ID Not Available
Target 13 HGNC ID Not Available
Target 13 Chromosome Location Not Available
Target 13 Locus Not Available
Target 13 SNPs SNPJam Report Link Image
Target 13 General References
  1. Covacci A, Rappuoli R: Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell. J Exp Med. 2000 Feb 21;191(4):587-92. [PubMed Link Image]
  2. Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, Rappuoli R, Covacci A: cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14648-53. [PubMed Link Image]
Target 13 Drug References Not Available
Drug Target 14 [top]
Target 14 ID 5660
Target 14 Name Esterase EstB
Target 14 Synonyms Not Available
Target 14 Gene Name estB
Target 14 Protein Sequence >Esterase EstB 
MTAASLDPTAFSLDAASLAARLDAVFDQALRERRLVGAVAIVARHGEILYRRAQGLADRE
AGRPMREDTLFRLASVTKPIVALAVLRLVARGELALDAPVTRWLPEFRPRLADGSEPLVT
IHHLLTHTSGLGYWLLEGAGSVYDRLGISDGIDLRDFDLDENLRRLASAPLSFAPGSGWQ
YSLALDVLGAVVERATGQPLAAAVDALVAQPLGMRDCGFVSAEPERFAVPYHDGQPEPVR
MRDGIEVPLPEGHGAAVRFAPSRVFEPGAYPSGGAGMYGSADDVLRALEAIRANPGFLPE
TLADAARRDQAGVGAETRGPGWGFGYLSAVLDDPAAAGTPQHAGTLQWGGVYGHSWFVDR
ALGLSVLLLTNTAYEGMSGPLTIALRDAVYAR
Target 14 Number of Residues 398
Target 14 Molecular Weight 41708
Target 14 Theoretical pI 5.12
Target 14 GO Classification
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
beta-lactamase activity
Process
physiological process
metabolism
cellular metabolism
drug metabolism
antibiotic metabolism
antibiotic catabolism
beta-lactam antibiotic catabolism
response to stimulus
response to abiotic stimulus
response to chemical stimulus
response to drug
response to antibiotic
Component
Not Available
Target 14 General Function Involved in beta-lactamase activity
Target 14 Specific Function Not Available
Target 14 Pathways Not Available
Target 14 Reactions Not Available
Target 14 Pfam Domain Function
Target 14 Signals
  • None
Target 14 Transmembrane Regions
  • None
Target 14 Essentiality Essential
Target 14 GenBank ID Protein Not Available
Target 14 UniProtKB/Swiss-Prot ID Q9KX40 Link Image
Target 14 UniProtKB/Swiss-Prot Entry Name Q9KX40_9BURK Link Image
Target 14 PDB ID 1CI9 Link Image
Target 14 PDB File Show
Target 14 3D Structure
Target 14 Cellular Location
  • Cytoplasmic
Target 14 Gene Sequence >1179 bp 
TCAGCGCGCGTAGACGGCGTCGCGCAAGGCGATCGTCAGCGGGCCCGACATGCCTTCGTA
GGCGGTATTGGTGAGCAGCAGCACGCTGAGTCCCAGCGCGCGGTCGACGAACCAGGAATG
GCCATAGACGCCGCCCCATTGCAGCGTCCCGGCGTGCTGCGGGGTGCCGGCCGCGGCCGG
ATCGTCGAGCACCGCGCTCAGGTAGCCGAAGCCCCAGCCGGGGCCGCGCGTCTCGGCGCC
GACTCCGGCCTGGTCGCGGCGCGCCGCGTCGGCCAGCGTCTCGGGCAGGAAACCGGGATT
GGCGCGGATCGCCTCGAGCGCGCGCAGGACGTCGTCGGCCGAGCCGTACATGCCGGCGCC
GCCCGAGGGATAGGCGCCCGGCTCGAACACGCGGGAGGGCGCGAAACGCACGGCCGCGCC
GTGGCCTTCCGGCAGCGGCACCTCGATGCCGTCGCGCATGCGCACCGGCTCCGGCTGGCC
GTCGTGGTAAGGCACGGCGAAGCGCTCGGGCTCCGCCGAGACGAAACCGCAATCGCGCAT
GCCGAGCGGCTGGGCGACCAACGCGTCCACCGCCGCGGCCAGCGGCTGCCCGGTGGCGCG
CTCGACCACCGCGCCGAGCACGTCGAGCGCCAGCGAATACTGCCAGCCGCTGCCCGGCGC
GAAGGACAGCGGCGCCGAGGCGAGGCGGCGCAGGTTTTCGTCGAGATCGAAGTCGCGCAG
GTCGATGCCGTCCGAGATGCCGAGCCGGTCGTACACGGAGCCGGCGCCCTCGAGCAGCCA
GTAGCCGAGCCCCGACGTGTGCGTGAGCAGGTGGTGAATCGTGACGAGCGGCTCGCTGCC
GTCGGCCAGCCGCGGCCGGAATTCGGGCAACCAGCGCGTGACCGGCGCGTCGAGCGCGAG
TTCGCCGCGCGCCACCAGCCGCAGCACCGCCAGCGCGACGATCGGCTTGGTCACCGAAGC
GAGCCGGAACAGCGTGTCCTCGCGCATCGGCCGACCTGCCTCTCGGTCGGCCAGGCCCTG
GGCGCGGCGATACAGGATCTCGCCGTGCCGCGCGACGATCGCCACCGCGCCGACCAGGCG
CCGTTCGCGCAGCGCCTGGTCGAACACGGCATCGAGACGCGCGGCCAGCGAGGCGGCATC
GAGGGAGAAAGCGGTCGGGTCGAGCGAGGCAGCGGTCAT
Target 14 GenBank Gene ID
Target 14 GeneCard ID Not Available
Target 14 GenAtlas ID Not Available
Target 14 HGNC ID Not Available
Target 14 Chromosome Location Not Available
Target 14 Locus Not Available
Target 14 SNPs SNPJam Report Link Image
Target 14 General References
  1. Petersen EI, Valinger G, Solkner B, Stubenrauch G, Schwab H: A novel esterase from Burkholderia gladioli which shows high deacetylation activity on cephalosporins is related to beta-lactamases and DD-peptidases. J Biotechnol. 2001 Jul 26;89(1):11-25. [PubMed Link Image]
  2. Wagner UG, Petersen EI, Schwab H, Kratky C: EstB from Burkholderia gladioli: a novel esterase with a beta-lactamase fold reveals steric factors to discriminate between esterolytic and beta-lactam cleaving activity. Protein Sci. 2002 Mar;11(3):467-78. [PubMed Link Image]
Target 14 Drug References Not Available
Drug Target 15 [top]
Target 15 ID 5661
Target 15 Name Aeromonas caviae phaC PHA synthase,complete cds
Target 15 Synonyms Not Available
Target 15 Gene Name Not Available
Target 15 Protein Sequence >Aeromonas caviae phaC PHA synthase,complete cds 
MSAQSLEVGQKARLSKRFGAAEVAAFAALSEDFNPLHLDPAFAATTAFERPIVHGMLLAS
LFSGLLGQQLPGKGSIYLGQSLSFKLPVFVGDEVTAEVEVTALREDKPIATLTTRIFTQG
GALAVTGEAVVKLP
Target 15 Number of Residues 136
Target 15 Molecular Weight 14086
Target 15 Theoretical pI 5.71
Target 15 GO Classification
Function
oxidoreductase activity
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring groups other than amino-acyl groups
acyltransferase activity
fatty-acid synthase activity
Process
physiological process
metabolism
cellular metabolism
organic acid metabolism
carboxylic acid metabolism
fatty acid metabolism
fatty acid biosynthesis
Component
protein complex
fatty acid synthase complex
Target 15 General Function Involved in fatty-acid synthase activity
Target 15 Specific Function Not Available
Target 15 Pathways Not Available
Target 15 Reactions Not Available
Target 15 Pfam Domain Function
Target 15 Signals
  • None
Target 15 Transmembrane Regions
  • None
Target 15 Essentiality Essential
Target 15 GenBank ID Protein Not Available
Target 15 UniProtKB/Swiss-Prot ID O32472 Link Image
Target 15 UniProtKB/Swiss-Prot Entry Name O32472_AERPU Link Image
Target 15 PDB ID 1IQ6 Link Image
Target 15 PDB File Show
Target 15 3D Structure
Target 15 Cellular Location Not Available
Target 15 Gene Sequence >405 bp 
ATGAGCGCACAATCCCTGGAAGTAGGCCAGAAGGCCCGTCTCAGCAAGCGGTTCGGGGCG
GCGGAGGTAGCCGCCTTCGCCGCGCTCTCGGAGGACTTCAACCCCCTGCACCTGGACCCG
GCCTTCGCCGCCACCACGGCGTTCGAGCGGCCCATAGTCCACGGCATGCTGCTCGCCAGC
CTCTTCTCCGGGCTGCTGGGCCAGCAGTTGCCGGGCAAGGGGAGCATCTATCTGGGTCAA
AGCCTCAGCTTCAAGCTGCCGGTCTTTGTCGGGGACGAGGTGACGGCCGAGGTGGAGGTG
ACCGCCCTTCGCGAGGACAAGCCCATCGCCACCCTGACCACCCGCATCTTCACCCAAGGC
GGCGCCCTCGCCGTGACGGGGGAAGCCGTGGTCAAGCTGCCTTAA
Target 15 GenBank Gene ID
Target 15 GeneCard ID Not Available
Target 15 GenAtlas ID Not Available
Target 15 HGNC ID Not Available
Target 15 Chromosome Location Not Available
Target 15 Locus Not Available
Target 15 SNPs Not Available
Target 15 General References
  1. Fukui T, Doi Y: Cloning and analysis of the poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) biosynthesis genes of Aeromonas caviae. J Bacteriol. 1997 Aug;179(15):4821-30. [PubMed Link Image]
Target 15 Drug References Not Available
Drug Target 16 [top]
Target 16 ID 5662
Target 16 Name YojF protein
Target 16 Synonyms Not Available
Target 16 Gene Name yojF
Target 16 Protein Sequence >YojF protein 
MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVVAYIRNAKVTYHQAKIK
GNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGKLAISLQISEKPFTV
Target 16 Number of Residues 117
Target 16 Molecular Weight 13042
Target 16 Theoretical pI 7.81
Target 16 GO Classification Not Available
Target 16 General Function Not Available
Target 16 Specific Function Not Available
Target 16 Pathways Not Available
Target 16 Reactions Not Available
Target 16 Pfam Domain Function Not Available
Target 16 Signals
  • None
Target 16 Transmembrane Regions
  • None
Target 16 Essentiality Essential
Target 16 GenBank ID Protein Not Available
Target 16 UniProtKB/Swiss-Prot ID O31858 Link Image
Target 16 UniProtKB/Swiss-Prot Entry Name O31858_BACSU Link Image
Target 16 PDB ID 1NJH Link Image
Target 16 PDB File Show
Target 16 3D Structure
Target 16 Cellular Location Not Available
Target 16 Gene Sequence >351 bp 
TTAAACTGTGAACGGTTTTTCGCTGATTTGCAGAGAAATAGCCAGTTTACCGCCCGGCAG
GTGTCCCGCCATTAATAAACGGTTTTCTTCATCTACCGTGTATTCAGTCAAGCCTTCAGC
ATAAATCCAGCCTTCTTCTGTTTTCAAGCCAACGCGGTAAGGCCCGTTGCCTTTGATTTT
TGCCTGATGATAAGTGACTTTTGCATTGCGAATATACGCAACAACCGTCATGTTCTTTTC
ATTTAAGTGCGCTGAATAAGAACCTGTGGTGGTTTCTAAATGGATATATACAGGGCGGTC
CGCATATCGTTCTAAAGATGCTTGCACATCTTCTTTTATGATCGCTTTCAT
Target 16 GenBank Gene ID
Target 16 GeneCard ID Not Available
Target 16 GenAtlas ID Not Available
Target 16 HGNC ID Not Available
Target 16 Chromosome Location Not Available
Target 16 Locus Not Available
Target 16 SNPs SNPJam Report Link Image
Target 16 General References
  1. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Codani JJ, Connerton IF, Danchin A, et al.: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [PubMed Link Image]
Target 16 Drug References Not Available
Drug Target 17 [top]
Target 17 ID 5663
Target 17 Name Hypothetical protein
Target 17 Synonyms Not Available
Target 17 Gene Name Not Available
Target 17 Protein Sequence >Hypothetical protein 
MTYVLYGIKACDTMKKARTWLDEHKVAYDFHDYKAVGIDREHLRRWCAEHGWQTVLNRAG
TTFRKLDEAQKADLDEAKAIELMLAQPSMIKRPVLELGGRTLVGFKPDAYAAALA
Target 17 Number of Residues 116
Target 17 Molecular Weight 13111
Target 17 Theoretical pI 8.69
Target 17 GO Classification
Function
catalytic activity
oxidoreductase activity
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
Component
Not Available
Target 17 General Function Involved in oxidoreductase activity
Target 17 Specific Function Not Available
Target 17 Pathways Not Available
Target 17 Reactions Not Available
Target 17 Pfam Domain Function
Target 17 Signals
  • None
Target 17 Transmembrane Regions
  • None
Target 17 Essentiality Essential
Target 17 GenBank ID Protein Not Available
Target 17 UniProtKB/Swiss-Prot ID Q9HXX5 Link Image
Target 17 UniProtKB/Swiss-Prot Entry Name Q9HXX5_PSEAE Link Image
Target 17 PDB ID 1RW1 Link Image
Target 17 PDB File Show
Target 17 3D Structure
Target 17 Cellular Location Not Available
Target 17 Gene Sequence >348 bp 
ATGACCTACGTTCTCTACGGCATCAAAGCCTGCGACACCATGAAGAAGGCTCGGACCTGG
CTCGACGAGCACAAGGTCGCCTACGACTTCCACGACTACAAGGCCGTCGGCATCGACCGC
GAACACCTGCGGCGCTGGTGCGCGGAGCACGGCTGGCAAACCGTCCTCAACCGCGCCGGC
ACCACCTTCCGCAAGCTCGACGAAGCGCAGAAGGCCGATCTCGACGAAGCCAAGGCGATC
GAGCTGATGCTGGCCCAGCCGTCGATGATCAAGCGCCCGGTGCTGGAGCTGGGCGGCAGG
ACGCTGGTCGGCTTCAAGCCCGACGCCTACGCCGCCGCCCTGGCCTGA
Target 17 GenBank Gene ID
Target 17 GeneCard ID Not Available
Target 17 GenAtlas ID Not Available
Target 17 HGNC ID Not Available
Target 17 Chromosome Location Not Available
Target 17 Locus Not Available
Target 17 SNPs Not Available
Target 17 General References
  1. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [PubMed Link Image]
Target 17 Drug References Not Available
Drug Target 18 [top]
Target 18 ID 5664
Target 18 Name Phospholipase A2-3
Target 18 Synonyms
  1. EC 3.1.1.4
  2. MP-III 4R
  3. Phosphatidylcholine 2-acylhydrolase
  4. Piratoxin-III
  5. PrTX-III
Target 18 Gene Name Not Available
Target 18 Protein Sequence >Phospholipase A2-3 
DLWQFGQMILKETGKLPFPYYTYGGCYCGVGGRRGLGTKDDRCCYVHDCCYKKLTGCPKT
DDRYSYSWLDLTIVCGEDDPCKELCECDKAIAVCFRENLGTYNKKYRYHLKPCKKADKPC
Target 18 Number of Residues 122
Target 18 Molecular Weight 13834
Target 18 Theoretical pI 8.06
Target 18 GO Classification
Function
binding
ion binding
cation binding
calcium ion binding
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
carboxylic ester hydrolase activity
lipase activity
phospholipase activity
phospholipase A2 activity
Process
physiological process
metabolism
primary metabolism
lipid metabolism
lipid catabolism
Component
Not Available
Target 18 General Function Involved in phospholipase A2 activity
Target 18 Specific Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has moderate PLA2 activity but a strong myotoxic activity. Also has anticoagulant activity
Target 18 Pathways Not Available
Target 18 Reactions Not Available
Target 18 Pfam Domain Function
Target 18 Signals
  • None
Target 18 Transmembrane Regions
  • None
Target 18 Essentiality Essential
Target 18 GenBank ID Protein Not Available
Target 18 UniProtKB/Swiss-Prot ID P58464 Link Image
Target 18 UniProtKB/Swiss-Prot Entry Name PA23_BOTPI Link Image
Target 18 PDB ID Not Available
Target 18 Cellular Location
  • Secreted protein
Target 18 Gene Sequence Not Available
Target 18 GenBank Gene ID
Target 18 GeneCard ID Not Available
Target 18 GenAtlas ID Not Available
Target 18 HGNC ID Not Available
Target 18 Chromosome Location Not Available
Target 18 Locus Not Available
Target 18 SNPs Not Available
Target 18 General References
  1. Toyama MH, Costa PD, Novello JC, de Oliveira B, Giglio JR, da Cruz-Hofling MA, Marangoni S: Purification and amino acid sequence of MP-III 4R D49 phospholipase A2 from Bothrops pirajai snake venom, a toxin with moderate PLA2 and anticoagulant activities and high myotoxic activity. J Protein Chem. 1999 Apr;18(3):371-8. [PubMed Link Image]
Target 18 Drug References Not Available
Drug Target 19 [top]
Target 19 ID 5665
Target 19 Name Trp operon repressor
Target 19 Synonyms Not Available
Target 19 Gene Name trpR
Target 19 Protein Sequence >Trp operon repressor 
MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEE
LLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKSD
Target 19 Number of Residues 109
Target 19 Molecular Weight 12355
Target 19 Theoretical pI 5.20
Target 19 GO Classification
Function
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
cell
intracellular
Target 19 General Function Involved in transcription factor activity
Target 19 Specific Function This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
Target 19 Pathways Not Available
Target 19 Reactions Not Available
Target 19 Pfam Domain Function
Target 19 Signals
  • None
Target 19 Transmembrane Regions
  • None
Target 19 Essentiality Essential
Target 19 GenBank ID Protein Not Available
Target 19 UniProtKB/Swiss-Prot ID P0A883 Link Image
Target 19 UniProtKB/Swiss-Prot Entry Name TRPR_SHIFL Link Image
Target 19 PDB ID 3WRP Link Image
Target 19 PDB File Show
Target 19 3D Structure
Target 19 Cellular Location
  • Cytoplasm (By similarity)
Target 19 Gene Sequence >327 bp 
ATGGCCCAACAATCACCCTATTCAGCAGCGATGGCAGAACAGCGTCACCAGGAGTGGTTA
CGTTTTGTCGACCTGCTTAAGAATGCCTACCAAAACGATCTCCATTTACCGTTGTTAAAC
CTGATGCTGACGCCAGATGAGCGCGAAGCGTTGGGGACTCGCGTGCGTATTGTCGAAGAG
CTGTTGCGTGGCGAAATGAGTCAGCGTGAGTTAAAAAATGAACTCGGCGCGGGCATCGCG
ACGATTACGCGTGGATCTAACAGCCTGAAAGCCGCGCCCGTGGAGCTGCGTCAGTGGCTG
GAAGAGGTGTTGCTGAAAAGCGATTGA
Target 19 GenBank Gene ID
Target 19 GeneCard ID Not Available
Target 19 GenAtlas ID Not Available
Target 19 HGNC ID Not Available
Target 19 Chromosome Location Not Available
Target 19 Locus Not Available
Target 19 SNPs SNPJam Report Link Image
Target 19 General References
  1. Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [PubMed Link Image]
  2. Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [PubMed Link Image]
Target 19 Drug References Not Available

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government. This project is also supported in part by GenomeQuest, Inc., an enterprise genomic information company serving the life science community.