| DrugBank ID |
Name |
Formula |
Weight |
DB04630
|
Aldosterone |
C21H28O5 |
360.4440 |
| ... and collecting duct, aldosterone has two main actions: 1) aldosterone acts on mineralocorticoid receptors (MR) on principal cells in the distal tubule of the kidney nephron, increasing the ... |
DB00700
|
Eplerenone |
C24H30O6 |
414.4914 |
| Aldosterone synthesis, which occurs primarily in the adrenal gland, is modulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and ... |
DB00421
|
Spironolactone |
C24H32O4S |
416.5730 |
| ... the effect of aldosterone by competing for intracellular aldosterone receptor in the distal tubule cells. This increases the secretion of water and sodium, while decreasing the excretion of ... |
DB01395
|
Drospirenone |
C24H30O3 |
366.4932 |
| ... the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. PA10729 97% 68873 12014580 DRSP
Drospirenona [inn-spanish]
Drospirenonum [inn-latin] 366 ... |
DB00519
|
Trandolapril |
C24H34N2O5 |
430.5372 |
| Decreased aldosterone secretion leads to diuresis, natriuresis, and a small increase of serum potassium. Tarka (Trandolapril + Verapamil hydrochloride) Trandolapril Trandolapril is the ethyl ester ... |
DB01342
|
Forasartan |
C23H28N8 |
416.5220 |
| ... which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance. Forasartan Forasartan, a specific angiotensin II ... |
DB00796
|
Candesartan |
C24H20N6O3 |
440.4540 |
| ... which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance. Tablet Oral 02239091 DB00796 Approximately 9 hours. |
DB00966
|
Telmisartan |
C33H30N4O2 |
514.6169 |
| Telmisartan works by blocking the vasoconstrictor and aldosterone secretory effects of angiotensin II. PA451605 Highly bound to plasma proteins (>99.5%), mainly albumin and a1-acid glycoprotein. |
DB01180
|
Rescinnamine |
C35H42N2O9 |
634.7160 |
| Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. PA451235 32681 8770 APRD00112 Methyl Trimethoxycinnamoylreserpate
Recinnamine
Rescinnamin
Reserpinene
Reserpinin ... |
DB00492
|
Fosinopril |
C30H46NO7P |
563.6625 |
| Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. PA449710 87% 55891 194429 APRD00526 Fosinopril Sodium Human overdoses of fosinopril have not been reported, but the most ... |
DB00584
|
Enalapril |
C20H28N2O5 |
376.4467 |
| Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. PA449456 20.1 to 89.1% 5362032 191211 APRD00510 Enalapril Maleate
Enalaprila [INN-Spanish]
Enalaprilat
Enalaprilum [INN ... |
DB00678
|
Losartan |
C22H23ClN6O |
422.9110 |
| ... which also stimulates the synthesis and release of aldosterone, blockage of its effects results in decreases in systemic vascular resistance. Neither Losartan or its metabolite inhibit the ... |
DB00542
|
Benazepril |
C24H28N2O5 |
424.4895 |
| ... which leads to decreased vasopressor activity and to decreased aldosterone secretion. Benazeprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin. |
DB01347
|
Saprisartan |
C25H22BrF3N4O4S |
611.4310 |
| Saprisartan blocks the renin-angiotensin-aldosterone system (RAAS) at the level of the AT1 receptor that mediates most, if not all, of the important actions of Ang II. Saprisartan binds ... |
DB01349
|
Tasosartan |
C23H21N7O |
411.4591 |
| Tasosartan blocks the renin-angiotensin-aldosterone system (RAAS) at the level of the AT1 receptor that mediates most, if not all, of the important actions of Ang II. Tasosartan binds reversibly ... |
DB00866
|
Alprenolol |
C15H23NO2 |
249.3486 |
| ... the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone ... |
DB00594
|
Amiloride |
C6H8ClN7O |
229.6270 |
| Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone. Alti-Amiloride HCTZ (Amiloride Hcl + Hydrochlorothiazide)
Ami-Hydro Tab (Amiloride Hcl ... |
DB00790
|
Perindopril |
C19H32N2O5 |
368.4678 |
| ... vasoconstriction, increased plasma renin activity and decreased aldosterone secretion. The latter results in diuresis and natriuresis and may be associated with a small increase of serum ... |
DB00960
|
Pindolol |
C14H20N2O2 |
248.3208 |
| ... the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone ... |
DB01203
|
Nadolol |
C17H27NO4 |
309.4006 |
| ... the production of renin, thereby inhibiting angiotensin II and aldosterone production. Nadolol therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone ... |